Proceedings of the National Academy of Sciences
Articles in this Issue
A causal role for the posterior corpus callosum in bimanual coordination
Interareal communication is crucial for coordinated brain function. Given the largely contralateral organization of the brain, bimanual coordination likely depends on interactions across the two cereb...
Thermal SU(2) lattice gauge theory for intertwined orders and hole pockets in the cuprates
The cuprate pseudogap phase displays Fermi arc spectral weight in photoemission and scanning tunneling microscopy, while recent magnetotransport observations yield evidence for the existence of hole p...
Ab initio molecular dynamics prediction and experimental validation of the 14:4 rare-earth oxide-phosphate structure
Rare-earth oxide-phosphates (historically termed oxyphosphates) occupy the compositional space between RE 2 O 3 and REPO...
An Ad5-vectored platform generating self-assembling VLPs elicits potent mucosal immunity against influenza A virus and SARS-CoV-2
Integrating complementary vaccine modalities is essential for combating emerging pathogens. Although the recent mRNA-VLP hybrids enable spontaneous virus-like particles (VLPs) self-assembly, thereby e...
Deep mining of the human antibody repertoire identifies frequent and genetically diverse CDRH3 topologies targetable by vaccination
Germline targeting vaccination strategies against highly variable pathogens such as HIV aim to elicit broadly neutralizing antibodies (bnAbs) with particular immunogenetic or structural features. The...
Computational design of an ultrapotent deltacoronavirus miniprotein inhibitor
Multiple spillovers of porcine deltacoronavirus (PDCoV) into humans in Haiti highlight its zoonotic potential and the need for targeted interventions. No approved vaccines or therapeutics are availabl...
Cytochrome P450 1B1 directs pathogenic Th17 cell generation and autoimmune disease by fine-tuning redox homeostasis and mitochondrial integrity
Th17 cell function is highly context-dependent and can be categorized into pathogenic and nonpathogenic Th17 cell subsets. Understanding the molecule control of pathogenic Th17 (pTh17) cell immunity w...
NOD2 drives regenerative fetal-like reprogramming in the intestinal epithelium
Inflammatory injury to the intestine triggers a reprogramming of the intestinal epithelium to a fetal-like state that drives rapid restoration of the epithelial barrier. Although the intestinal microb...
Structural insights into biased signaling at chemokine receptor CCR7
CC chemokine receptor 7 (CCR7), which orchestrates adaptive immunity, exhibits a phenomenon known as biased agonism. CCL19 induces robust G-protein signaling and β-arrestin recruitment, leading to tra...
Neural correlates of perceptual decision-making in the primary somatosensory cortex
The brain is thought to produce decisions by gradual accumulation of sensory evidence through a hierarchically organized feedforward cascade of neuronal activities that transforms early stimulus repre...
Multimodal analysis reveals cellular diversity and divergent circuits of the zona incerta
The zona incerta (ZI) plays an important role in diverse behavioral functions and is an emerging clinical target for deep brain stimulation to treat neurological conditions. Despite their importance,...
The allometry of vertebrate pursuit predation
Pursuit and evasion dynamics are a general phenomenon observed in predator–prey interactions across terrestrial, aquatic, and aerial domains. Differences in body mass and domain generate variation in...
Fra-2 controls the response to the KRAS inhibitor MRTX-1133 in pancreatic ductal adenocarcinoma
KRAS mutations are a hallmark of pancreatic ductal adenocarcinoma (PDAC), driving tumor initiation and progression in the vast majority of cases, with KRAS G12D...
Exploring PrP <sup>C</sup> unfolding as a critical step preceding its refolding in the context of PrP <sup>Sc</sup> propagation
It might have been believed that elucidation of the atomistic structure of PrP Sc would lead to an immediate understanding of the mechanism of prion propagation...
Lipid metabolism in adipocytes modulates tumor growth at a distance through Nplp2-mediated Wnt5 signal
The host metabolic state can potentially affect the growth trajectories of tumors growing at local sites, which are highly variable and unpredictable among populations. The molecular links between sys...
Computational design of HLA class I superbinders for broad T cell immunogenicity
Human leukocyte antigen (HLA) class I molecules are highly polymorphic, restricting peptide binding to narrow sequence subsets. Designing peptides that bind multiple HLA supertypes—termed superbinders...
Uncovering how transport access reduces deprivation: When colocation misleads
Since transport access determines who can reach jobs, education, healthcare, and community life, governments increasingly use accessibility improvements to reduce deprivation and tackle social exclusi...
An exceptionally conductive hydrogel for all-organic, ultraflexible, and chronic neural interfaces
Chronic neural interfaces are essential for advancing brain–computer interfaces, neuroprosthetics, and neuromodulation technologies. However, a long-standing trade-off between performance and longevit...
Structural rewiring of IL-7R dimerization by an oncogenic transmembrane mutation can be reversed by rational design
Mutations within the transmembrane domains (TMDs) of single-pass transmembrane receptors often cause aberrant, ligand-independent receptor signaling associated with diverse malignancies, but their mec...
Mitochondrial fusion heterogeneity drives bidirectional tumor phenotypic transition in combined hepatocellular–cholangiocarcinoma
Dysregulation of mitochondrial dynamics modulates malignant cell fate; however, the substantial heterogeneity in mitochondrial dynamics among tumor cells within individual tumor nodules and the result...
HIV-1 infection induces Vif-mediated SUMOylation of host RNA splicing factors important for proper viral RNA splicing
SUMOylation is a dynamically regulated post-translational modification involving covalent attachment of small ubiquitin-like modifiers (SUMOs) to lysine residues of target proteins. SUMOylation modula...
Parallel algorithms for phylogenetic inference under a structured coalescent approximation
Advances in molecular epidemiology and computational modeling have improved our ability to track pathogen evolution, but accurate reconstruction of spatiotemporal transmission remains essential for ep...
Erythroferrone derived from osteoblasts regulates stress erythropoiesis
Erythroferrone (ERFE), secreted by erythroblasts, is regarded as a classical regulator of iron metabolism through its suppression of hepcidin. Thus, as a consequence of insufficient hepcidin suppressi...
An Octopus probe for high-performance >1,300 nm NIR-II fluorescence molecular imaging of cancer
In surgical oncology, precise intraoperative delineation of malignant tumors for complete yet non-excessive resection has been challenging. Near-infrared II (NIR-II, 1,000 to 3,000 nm) imaging enables...
A few key species drive community thermophilization under experimental warming
Community thermophilization—the process by which communities are increasingly dominated by species from warmer biogeographic regions—is a widespread ecological response to warming. However, most studi...