Proceedings of the National Academy of Sciences
Articles in this Issue
Plasticity-led evolution of the gut length in wild medaka
Hopx(+) optic nerve head-astrocytes counter neuronal stress and glaucoma damage
Retinal ganglion cell (RGC) axons form the optic nerve (ON). Numerous age-related ON diseases, including glaucoma, the second most common cause of worldwide blindness, result from multiple RGC stresso...
Danger at the border: Rac turns nibblers into murderers
Kinetochore proteins control microtubule dynamics in postmitotic neurons to regulate the formation of dendritic spines
Kinetochore proteins, long studied for their role in cell division, are also required for the proper postmitotic development of hippocampal and cortical neurons. Proteins of the kinetochore complex we...
Accurate and scalable deep Maxwell solvers
Neural networks have promise as surrogate partial differential equation (PDE) solvers, but it remains a challenge to use these concepts to solve problems with high accuracy and scalability. In this wo...
A century of suicide: Insights from long-term data in the United States
The 2024 National Strategy for Suicide Prevention identifies suicide as “an urgent and growing public health crisis” driven partly by mental health and overdose rates, the COVID-19 pandemic, and decli...
Unexpected behavior of ultra-low-crosslinked microgels in crowded conditions
Ultra-low-crosslinked (ULC) microgels are among the softest colloidal particles nowadays routinely synthesized experimentally. Despite a growing literature of experimental results, their microscopic b...
Correction for Dunlop et al., Live-cell 3D-SIM of Rift Valley fever virus NSs filaments reveals a polygon web architecture
Informal connections outweigh coauthorship ties in academic impact
Past work has documented the importance of formal collaboration, particularly coauthorship, in increasing research productivity and innovation. However, we know much less about how informal collaborat...
Retraction for Liaki et al., A targeted combination therapy achieves effective pancreatic cancer regression and prevents tumor resistance
Behavioral responses to wildfire smoke: Insights from smartphone location data
Although wildfire smoke is a major public health concern, relatively little is known about individual avoidance behavior. In this paper, we use smartphone-location data to study behavioral responses t...
Holocene Nile dynamics shaped the physical and cultural landscape of ancient Nubia
The Nile River played a central role in ancient civilizations of Northeast Africa, yet its response to Holocene climate change and its impact on societies along its course remain poorly understood. He...
An auxin-induced transcriptional cascade CmBES1–CmSAUR66 orchestrates the ray floret development in <i>Chrysanthemum morifolium</i>
Sympetaly (fused petals) is a key morphological innovation that has arisen multiple times during evolution. It occurs via one of two developmental pathways: late sympetaly (from initially separate pet...
Solution-state nanoconfined aggregation and microstructure evolution in blends of conjugated polymers and elastomers
Emerging wearable health monitoring technologies require conformable and stretchable devices. Polymer semiconductors composed of π-conjugated polymer aggregates in an elastomeric matrix are remarkable...