Proceedings of the National Academy of Sciences
Articles in this Issue
Educational policies can strengthen climate coalitions
Building public support for ambitious climate policies is a central challenge for governments seeking to decarbonize their economies. Many climate change mitigation policies impose visible material co...
Cysteine thiol-to-sulfonate oxidation induces unfolding for the functional switching of the extracellular HMGB1 protein
Oxidation of cysteine thiols to sulfonate groups (–SO 3 – ) by reactive oxygen species can regulate protein function. Near the end of inflam...
Deciphering and targeting the pathogenic circuit of nonlytic hepatitis E virus infection using macrophage-augmented organoids
The pathophysiology caused by nonlytic viral infections is complex, often driven by macrophage-mediated immune responses that lead to hyperinflammation and collateral tissue damage. To conceptualize t...
A broad-spectrum inhibitor of copper-exporting P <sub>1B</sub> -type ATPases
Copper (Cu) transporting ATPases represent a highly conserved subclass of P-type ATPases with critical roles in Cu export and metalloenzyme synthesis. Despite their important biological roles and asso...
Ecological stability through nonlinear fluctuations and the portfolio effect
Much ecological theory has pursued understanding the mechanisms that stabilize communities, yet empirical analyses reveal deterministic nonlinear dynamics such as oscillations and chaos to be widespre...
NEK2 drives pathogenesis, drug resistance, and LMP1 expression in EBV-positive non-Hodgkin lymphoma
Non-Hodgkin lymphoma (NHL) is one of the most common cancers worldwide, representing 90% of malignant lymphomas. NHL is a diverse group of malignancies, and a subset of these lymphomas are caused by i...
The Antarctic Treaty System needs a disaster management authority to guard the continent against disasters
Cross-individual translation of spontaneous zebrafish brain activity through a shared latent representation
Spontaneous activity is a hallmark of brain function, reflecting the underlying circuit organization. Identifying conserved structure across individuals in this self-sustained activity has remained a...
Data-driven particle dynamics: Structure-preserving coarse-graining for emergent behavior in nonequilibrium systems
Multiscale systems are ubiquitous in science and technology, but are notoriously challenging to simulate as short spatiotemporal scales must be appropriately linked to emergent bulk physics. When expe...
Soft, skin-interfaced electronics enable cannula-free wireless monitoring of sleep respiration
Sleep-related breathing disorders are prevalent yet frequently underdiagnosed, in part due to limitations of conventional respiratory monitoring technologies. Standard nasal cannulas introduce airflow...
<i>Wolbachia</i> -mediated viral transmission enhancement in insect vectors
The white-backed planthopper ( Sogatella furcifera ) serves as the vector for the southern rice black-streaked dwarf virus (SRBSDV), with varying transmission e...
Phospholipase D regulates on-membrane diffusivity of a myristoylated protein and defines the PIP3 patch territory
In living cells, the control of molecular diffusion is pivotal for highly fluidic membranes to serve as substrates for biochemical reactions and cytoskeletal assemblies. Lateral diffusion in membranes...
QnAs with E. Dale Abel
Human pannexin mutations and their implications in erosive osteoarthritis
Erosive hand osteoarthritis (EHOA) is a chronic joint disease characterized by severe inflammation and degeneration of cartilage and bone tissue. As this disease is multifactorial in nature, the molec...
Superconductivity suppression and bilayer decoupling in Pr-substituted YBa <sub>2</sub> Cu <sub>3</sub> O <sub> 7− <i>δ</i> </sub>
The mechanism behind superconductivity suppression induced by Pr substitutions in YBa 2 Cu 3 O...
Inside-out-engineered CuO <sub>x</sub> /Ru sites for efficient electrochemical nitrate reduction to ammonia
Electrochemical nitrate reduction reaction (NO 3 − RR) provides a sustainable approach for both NO 3...
ICMT supports BRAF <sup>V600E</sup> -driven tumor growth by membrane targeting of the CAAX protein INPP5E
Isoprenylcysteine carboxyl methyltransferase (ICMT) catalyzes C-terminal methylation of prenylated CAAX proteins, a final processing step promoting membrane association and signaling. Although ICMT ha...
Profile of Richard Robson, Susumu Kitagawa, and Omar M. Yaghi: 2025 Nobel laureates in Chemistry
The 2025 Nobel Prize in Chemistry honors Richard Robson, Susumu Kitagawa, and Omar M. Yaghi for establishing metal-organic frameworks (MOFs) as a new class of crystalline porous materials and, more br...
Predicting rates of manganese oxide reduction from thermodynamic driving forces and structural properties
Manganese (oxyhydr)oxides are abundant redox-active minerals that influence diverse biogeochemical processes, yet their redox reactivity remains poorly understood due to variations in mineral structur...
Rapid sensing and relaying of cellular hyperosmotic stress signals via RAF–SnRK2 core condensates
Hyperosmolarity caused by drought, high salinity, or cold stress inhibits plant growth and crop productivity. A conserved protein-kinase cascade of cytosolic B-RAFs and SnRK2s is rapidly activated upo...
Highlighting a science strategy for human exploration of Mars
Dpp and immune response pathway factors mediate paracrine induction of senescent cells in <i>Drosophila</i>
Transition toward senescence is a cellular response to various forms of stress. This phenomenon is evolutionarily conserved across species, from insects to humans. Senescent cells (SCs) permanently wi...
Directly adopting inverse biosensors to image live cell enzyme activities in nanodomains
Many biochemical pathways can be monitored by outfitting molecular switches with reporting mechanisms such as fluorescence. The output of these biosensors can either increase or decrease upon target a...
PAM1 regulates meiosis by coupling RNA processing to the chromosome axis
Meiosis is a fundamental process responsible for sexual reproduction and generating genetic diversity in the progeny. Its successful completion requires fine-tuning of expression programs of many gene...
Speed and quality of complex strategic decisions
Many strategic decisions involve both substantial complexity and time pressure, but the association between decision speed and decision quality of cognitively demanding strategic decisions is not well...