Proceedings of the National Academy of Sciences
Articles in this Issue
A hemispheric decoding principle for vestibular heading perception in the posterior sylvian area
Identifying functional links between neural activity and behavioral perception is a fundamental neuroscience issue for inferring causality and means of information-decoding. Using perturbation methods...
Evolution of noisy learning in games
People make strategic decisions many times a day—during negotiations, when coordinating actions with others, or when choosing partners for cooperation. The resulting dynamics can be studied with learn...
Spatiotemporal control of PIWI compartmentalization by mitochondrial scaffolds defines pachytene piRNA pathway organization
Pachytene piRNAs are the least understood class of piRNAs in the mammalian male germ line. During meiosis, their biogenesis occurs near the mitochondrial outer membrane in germ granules known as inter...
Fungal proliferation before and after the Cretaceous–Paleogene mass extinction event in North America
Palynological evidence of postcatastrophe fungal proliferation after global calamities has been found for the Permian–Triassic and Cretaceous–Paleogene (K/Pg) extinction events. However, unlike the gl...
Binocular vision emerges from the coordinated development of orbit convergence, eye orientation, and high-acuity retinal specializations
Binocular vision requires both eyes to be aligned such that their visual fields overlap. A long-standing premise derived from comparative studies is that the orientation of the orbits determines eye p...
Field data challenge predictions of universal crop pest proliferation under warming
Models generated from laboratory-based thermal performance experiments predict that arthropod crop pest densities will escalate under rising temperatures. Conversely, natural enemies are predicted to...
Empirical validation of race-neutral normative brain morphometry models across ethnoracially diverse populations
Normative models of brain morphometry quantify individual deviations from typical anatomical patterns and hold promise for enhancing clinical decision-making. However, their clinical utility depends c...
Lineage-specific evolution of regulatory landscapes in a polyploid plant and its diploid progenitors
Cis -regulatory elements are specific DNA sequences that control gene expression in a spatiotemporal manner, and variation within these elements represents a major source of phenot...
Temporally gated offline engram ensemble reverberation in the lateral amygdala is required for fear memory consolidation
Memories are encoded by sparsely distributed neuronal ensembles, or engrams, yet how newly allocated engram neurons are consolidated to support subsequent memory retrieval remains unclear. While offli...
Selective targeting of kinesin on lipid droplets in the liver reduces plasma lipids
The liver controls plasma lipids by secreting lipid-rich very low density lipoproteins (VLDL) into blood. Inside hepatocytes in the liver, Lipid Droplets (LDs) are transported to the Smooth Endoplasmi...
Ancestral splice variation is a key substrate for rapid diversification in African cichlids
Adaptive radiation is a major driver of biodiversity. In some of the largest radiations, increasing evidence suggests that explosive morphological diversification is often fueled by standing genetic v...
Modular genetic architecture underlies human hand and foot evolution
The functional divergence of the hand and foot for prehension and locomotion, respectively, has long been recognized as a critical event in human evolution, and involved substantial changes to the ske...
SFTSV NSs protein is a tick antiviral RNAi response suppressor
Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne phenuivirus causing high mortality in humans. While the nonstructural protein NSs is dispensable for replication in...
Correlating surface adsorbate configuration and electrochemical performance of IrO <sub>2</sub> during seawater-relevant electrolysis
Seawater electrolysis alleviates freshwater demand to produce clean hydrogen while eliminating the need for water purification steps. The anodic process, seawater oxidation, typically requires high ov...