Proceedings of the National Academy of Sciences
Articles in this Issue
Counting birds while taking fire: Biodiversity monitoring in a war zone
Reply to Topaz and Bahl: Interpreting a post-2022 lexical shift in academic prose
Correction for Wu et al., Paramyxovirus infection driven by heteromultivalent sialoglycotope binding
Heat tolerance decreases and cold tolerance increases with elevation for a species-rich insect family on a tropical volcano
The climate crisis is moving the high ambient temperatures common in lower elevation tropical forests upslope into areas where they would not have occurred historically. Tropical invertebrates may be...
PLCβs are recruited to the plasma membrane in macrophages by both Gβγ and Gα <sub>q</sub>
PLCβ enzymes cleave PIP2 from the plasma membrane, producing IP3 and DAG, which regulate intracellular Ca 2+ levels and protein kinase C activity, respectively....
When coordination is avoidable: A monotonicity analysis of organizational tasks
Organizations devote substantial resources to coordination, yet which tasks actually require it for correctness remains unclear. The problem is acute in multiagent AI systems, where coordination cost...
Sources of technological innovation
Correction for Meng et al., Rethinking energy transition strategies for the European Union amid rising energy prices
Lexical change is not a calibrated measure of LLM prevalence or its determinants
PLK1-mediated phosphorylation of PHGDH reprograms serine metabolism in advanced prostate cancer
Metabolic reprogramming is a hallmark of cancer, enabling tumor cells to meet their increased biosynthetic and energetic demands. Although cells possess the capacity for de novo serine biosynthesis, m...
Insights into hominin body size, locomotion, and behavior from Early Pleistocene trackways in northern Kenya
The Early Pleistocene fossils of the Koobi Fora Formation, northern Kenya, record two well-documented hominin genera, Homo and Paranthropus...
ICE arrests, 2015–2026: Variation in targeting, method, and geography
We analyze and decompose administrative data on all 1.6 million US Immigration and Customs Enforcement (ICE) arrests from October 2015 to March 2026. Our results reveal that the reality of immigration...
MORC2 controls HIF-1α stability via an HDAC4-dependent mechanism to regulate erythropoiesis
The hypoxia-inducible factor (HIF) signaling pathway is essential for cellular adaptation to low oxygen. Although the canonical PHD-pVHL pathway that mediates HIF-α degradation under normoxia is well...
Palindrome in the sequence of the ribosomal peptidyl transferase center suggests a protoribosome emergence scheme
The emergence of a simple version of the modern ribosome represents an indispensable step in the evolution of life as we know it. Standalone dimeric protoribosome models, derived from the peptidyl tra...
Reply to Szöllősi and Williams: The observation threshold mitigates the bias of transient genes on ancestral reconstruction
Sprint-like cardiac dynamics support repeated acrobatic lunges in foraging rorqual whales
The dive response decreases heart rate, regulates blood flow distribution, conserves oxygen, and extends dive duration. In diving animals, dive heart rate can be modulated to meet increased demands of...
Methionine oxidation alters both helical assembly and disordered contacts in human TDP-43 C-terminal domain phase separation
TAR DNA binding protein 43 (TDP-43), a key protein linked to ALS pathology, undergoes phase separation and forms functional assemblies via condensation within cells. The conserved region (CR) within i...
Going in reverse to get it right in RNA replication
Correction for Zhang et al., Programmable DNA hydrogels for dual-mode PD-L1 suppression via polyvalent LYTAC mimics and transcriptional silencing
Christopher A. Sims (1942–2026): Paradigm-shifting macroeconomist and econometrician
Christopher A. Sims, who died on March 14, 2026, left behind an indelible mark on macroeconomics and econometrics. His Nobel Prize winning research reshaped the paradigm for empirical macroeconomics,...
Reversing vegetable biodiversity loss to diversify diets
Vegetables are a critical component of diets, with inadequate intake of this essential food group leading to poor dietary quality and malnutrition. Food system assessments identify insufficient produc...