Proceedings of the National Academy of Sciences
Articles in this Issue
Adaptive molecular convergence is pervasive across deep time and largely decoupled from phenotypic convergence
Reuse of homologous genes during the evolution of similar traits or ecological transitions is often taken as evidence that evolution is repeatable at the molecular level. To study gene reuse, biologis...
Pair living emerged early in placental mammals
It is widely assumed that the first placental mammals were solitary. Here, we tested this assumption and which ecological and life history factors are related to mammalian social organization. We comp...
Science for America’s next 250 years
Proteolytic activation of c-MYC facilitated by DOT1L
c-MYC is a key regulator of growth and metabolism. Functional and molecular cooperation between the H3K79 methyltransferase DOT1L and c-MYC has been reported in several human cancer types, but the nat...
Psychological inoculation against climate doom
Individuals encounter “climate doom,” extreme portrayals of climate change, on social media. While climate doom may be intended to motivate action, it may also be perceived as manipulative or elicit h...
Hypermutability of integrated sequences of viral origin in a chlorarachniophyte
Mutations provide the raw material for evolution, but mutation rates are not uniform across genomes. Using a mutation accumulation experiment in the marine phytoplankton Bigelowiel...
The human hippocampus can pattern separate memories by meaning
Hippocampal pattern separation is a neural operation supporting mnemonic discrimination of highly similar memories by orthogonalizing neural inputs into nonoverlapping representations. In humans, patt...
Distinct repair processes produce APOBEC-induced deletions, tandem substitutions, and complex mutations in yeast and human cells
APOBEC3A (A3A) and APOBEC3B (A3B) induce single base substitution signatures SBS2 and SBS13, which are composed of C>T and C>G mutations, respectively, at T C...
Anterior and posterior retrosplenial cortex employ distinct strategies for egocentric–allocentric transformation in spatial coding
The transformation from egocentric to allocentric spatial coordinates is a critical process in neural spatial computation. The retrosplenial cortex (RSC) is hypothesized to serve as a central hub for...
The global demand and potential public health impact of oral antiviral treatment stockpile for influenza pandemics
Antiviral drugs are among the few countermeasures available during the critical interval between the emergence of a novel influenza pandemic and vaccine availability. Antiviral stockpiling is a key pa...
The cortical scene processing network emerges in infancy, prior to independent navigation experience
Sighted people rely on vision to recognize and navigate the local environment. By adulthood, human cortex contains at least three regions that respond selectively to visual scene information, but it r...
Calcitriol–PKM2 axis drives transcriptional and metabolic reprogramming of ILCPs into intestinal dual-cytokine-producing ILC3s
Vitamin D deficiency is associated with dysregulated alloimmune responses, but the mechanisms by which its active metabolite calcitriol shapes innate lymphoid cell (ILC) development and function remai...
Correction for Zhang et al., Host genetic regulation of rumen 6-hydroxymelatonin reduces methane emissions in dairy cattle
Rapid microbial production of long-lived dissolved organic carbon in the global ocean
Marine microbes have long been regarded as central to replenishing the ocean’s reservoir of recalcitrant dissolved organic matter (RDOM). However, molecular-level evidence for their role remains incon...
The free-living wellspring of symbiotic nitrogen fixation in <i>Bradyrhizobium</i>
The evolutionary origin of nitrogen-fixing symbiosis has been a long-standing question. To address this, we focused on Bradyrhizobium , a globally abundant bact...
Correction for Madangopal et al., Distinct prelimbic cortex ensembles encode response execution and inhibition
Ancestral gene content estimates under gain–loss–duplication depend on the chosen observation threshold
Dual control of PIP2 drives germline/soma segregation in <i>Drosophila</i>
Embryonic cell fate decisions require precise spatial coordination between competing lineage determinants. In the syncytial Drosophila embryo, primordial germ c...
Can stimulating ownership increase fertility: Evidence from housing interventions in China
Declining fertility and the emergence of very low TFR’s in the Asian economies has increased the focus on how to change the direction of the fertility trend. Several countries in Europe and Asia have...
Abrupt transition to irreversible damage in the overdrafted Sacramento Valley aquifer system
Groundwater extraction decreases water pressure in aquifer systems, causing reversible or irreversible deformation of the water-bearing layers that manifests as recoverable or permanent displacements...
Discovery of a phenazine–thiol conjugase from sparse data using genome-informed machine learning
Machine learning has enabled powerful biological discoveries using models trained on large datasets. However, for many important biological questions, such as identifying enzymes that transform unders...
Coupled metabolic reactions relevant to early biological evolution
Dominant functional group explains global bird diversity responses to farmland abandonment
Reversing biodiversity declines will require redesigning agricultural landscapes and their management. Farmland abandonment and intensification are emerging as major drivers of biodiversity changes, a...
From fruit flies to football: Violent <i>Drosophila</i> provide novel ideas about CTE
Climate warming and atmospheric deposition jointly accelerate the Antarctic Peninsula atmosphere–glacier–land–ocean mercury loop
Mercury (Hg) is a toxic pollutant of global concern that threatens ecosystem and human health. Its cycle is being jointly reshaped by anthropogenic emissions and polar warming, yet the response of the...