Proceedings of the National Academy of Sciences
Articles in this Issue
Substrate and climate determine terrestrial litter decomposition
Litter decomposition is a fundamental biogeochemical process for carbon flux and nutrient cycling in terrestrial ecosystems, yet the global variation in decomposition rates and their covariations with...
Scavenger endothelial cells alleviate tissue damage by engulfing toxic molecules derived from hemolysis
Hemolysis induces tissue damage by releasing cellular contents into the plasma. It is widely accepted that hemolysis-derived toxic molecules are cleared by macrophages or metabolized in hepatocytes. I...
Retraction for Hiramatsu et al., DAT (deacylating autotransporter toxin) from <i>Bordetella parapertussis</i> demyristoylates Gα <sub>i</sub> GTPases and contributes to cough
Maple samaras recover autorotation following raindrop collisions
Samaras are known for their elegant and robust autorotation, a resilience that persists in the adverse conditions imposed by high-speed raindrops. Like flying insects, samaras descending from tall tre...
Bacterial species with different nanocolony morphologies have distinct flow-dependent colonization behaviors
Fluid flows are dominant features of many bacterial environments, and flow can often impact bacterial behaviors in unexpected ways. For example, the most common type of cardiovascular infection is hea...
Wholesale flat subduction of the Indian slab and northward mantle convective flow: Plateau growth and driving force of the India–Asia collision
The tectonic evolution of the Tibetan Plateau has been influenced by continental collision and postcollisional convergence of Indian and Eurasian plates, both of which have undoubtedly imposed their i...
Seesaw protein: Design of a protein that adopts interconvertible alternative functional conformations and its dynamics
According to classical Anfinsen’s dogma, a protein folds into a single unique conformation with minimal Gibbs energy under physiological conditions. However, certain proteins may fold into two or more...
Photostationary state assumption seriously underestimates NO <sub>x</sub> emissions near large point sources at 10 to 60 m pixel resolution
Identification of FSH-regulated and estrous stage–specific transcriptional networks in mouse ovaries
Follicle-stimulating hormone (FSH) acts by binding to FSHRs expressed on ovarian granulosa cells and produces estradiol. FSH is essential for female fertility because mice lacking FSH (...
In the shadow of antibiotics
Reply to Chen et al.: Coarse simulations overestimate the distance to recover NO–NO <sub>2</sub> –O <sub>3</sub> photochemical steady state in fresh NO <sub>x</sub> plumes
Reenacting a mouse genetic evolutionary arms race in yeast reveals that SLXL1/SLX compete with SLY1/2 for binding to Spindlins
The house mouse X and Y chromosomes have recently acquired multicopy, rapidly evolving gene families representing an evolutionary arms race. This arms race between proteins encoded by X-linked...
Inhibition of GABARAP or GABARAPL1 prevents aminoglycoside- induced hearing loss
Aminoglycosides (AGs) are highly potent, broad-spectrum antibiotics frequently used as first-line treatments for multiple life-threatening infections. Despite their severe ototoxicity, causing irrever...
Giant RNA genomes: Roles of host, translation elongation, genome architecture, and proteome in nidoviruses
Positive-strand RNA viruses of the order Nidovirales have the largest known RNA genomes of vertebrate and invertebrate viruses with 36.7 and 41.1 kb, respective...
Double assurance in the induction of axial development by egg dorsal determinants in <i>Xenopus</i> embryos
We recently reported that microinjection of Xenopus nodal-related ( xnr ) mRNAs into β-catenin-depleted...
Interrogating nucleotide sequences with AI to understand codon usage patterns
Resolving the dynamic correlated disorder in KTa <sub> 1− <i>x</i> </sub> Nb <sub> <i>x</i> </sub> O <sub>3</sub>
Understanding the complex temporal and spatial correlations of ions in disordered perovskite oxides is critical to rationalize their functional properties. Here, we provide insights into the longstand...
Ethylene response factor SlERF.D6 promotes ripening in part through transcription factors SlDEAR2 and SlTCP12
Ripening is crucial for the development of fleshy fruits that release their seeds following consumption by frugivores and are important contributors to human health and nutritional security. Many gene...
Decoding resistance in the age of T6SS warfare
Clinical evaluation of patterned dried plasma spot cards to support quantification of HIV viral load and reflexive genotyping
Quantifying viral load, a key indicator required to achieve control and elimination of the HIV epidemic, requires cell-free plasma or serum to ensure measurements are not biased by proviral DNA contai...
Thermoelastic twisting–assisted crystal jumping based on a self-healing molecular crystal
Adaptive crystals have attracted significant attention from solid-state chemists and crystal engineers for their promising applications in memories, capacitors, sensors, and actuators. Among them, the...
Machine learning–enhanced surface-enhanced spectroscopic detection of polycyclic aromatic hydrocarbons in the human placenta
The detection and identification of polycyclic aromatic hydrocarbons (PAHs) and their derivatives, polycyclic aromatic compounds (PACs), are essential for environmental and health monitoring, for asse...
Dynamic changes in histone lysine lactylation during meiosis prophase I in mouse spermatogenesis
Male germ cells, which are responsible for producing millions of genetically diverse sperm through meiosis in the testis, rely on lactate as their central energy metabolite. Recent study has revealed...
Debiasing job ads by replacing masculine language increases gender diversity of applicant pools
Job advertisements for jobs in male-dominated fields tend to contain more masculine language, and a commonly proposed intervention to increase gender diversity in applicant pools is to remove this lan...
Ancient origin and high diversity of zymocin-like killer toxins in the budding yeast subphylum
Zymocin is a well-characterized killer toxin secreted by some strains of the yeast Kluyveromyces lactis . It acts by cleaving a specific tRNA in sensitive recip...