Proceedings of the National Academy of Sciences
Articles in this Issue
EGFR-induced lncRNA <i>TRIDENT</i> promotes drug resistance in non–small cell lung cancer via phospho-TRIM28-mediated DNA damage repair
Long noncoding RNAs (lncRNAs) play numerous roles in cellular biology and alterations in lncRNA expression profiles have been implicated in a variety of cancers. Here, we identify and characterize a l...
The NAE1-mediated neddylation operates as an essential post-translational modification checkpoint for effector CD8 <sup>+</sup> T cells
Optimal activation of CD8+ T cells is crucial for immunity-mediated destruction of cancer, requiring a substantial amount of proteins involved in metabolism, proliferation, and effector function. Desp...
Dynamic investigation of hypoxia-induced L-lactylation
The recently identified histone modification lysine lactylation can be stimulated by L-lactate and glycolysis. Although the chemical group added upon lysine lactylation was originally proposed to be t...
Brain aging shows nonlinear transitions, suggesting a midlife “critical window” for metabolic intervention
Understanding the key drivers of brain aging is essential for effective prevention and treatment of neurodegenerative diseases. Here, we integrate human brain and physiological data to investigate und...
Dynamic and context-dependent keystone species effects in kelp forests
Sea otters are an iconic keystone predator that can maintain kelp forests by preying on grazing invertebrates such as sea urchins. However, the effects of sea otters on kelp forests vary over their ge...
Record of paleo water divide locations reveals intermittent divide migration and links to paleoclimate proxies
Drainage divide migration alters the geometry of drainage basins, influencing the distribution of water, erosion, sediments, and ecosystems across Earth’s surface. The rate of divide migration is gove...
Mechanical ventilation energy analysis: Recruitment focuses injurious power in the ventilated lung
The progression of acute respiratory distress syndrome (ARDS) from its onset due to disease or trauma to either recovery or death is poorly understood. Currently, there are no generally accepted treat...
Direct observation of cholesterol monohydrate crystallization
Cholesterol crystallization is integral to the pathology of diseases such as atherosclerosis and gallstones, yet the relevant mechanisms of crystal growth have remained elusive. Here, we use a variety...
Correction for Huseby et al., Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria
Specific microbial ratio in the gut microbiome is associated with multiple sclerosis
Gut microbiota dysbiosis is associated with multiple sclerosis (MS), but the causal relationship between specific gut bacteria and MS pathogenesis remains poorly understood. Therefore, we profiled the...
Immobile lipopolysaccharides and outer membrane proteins differentially segregate in growing <i>Escherichia coli</i>
The outer membrane (OM) of gram-negative bacteria is a robust, impermeable barrier that excludes many classes of antibiotics. Contrary to the classical model of an asymmetric lipid bilayer, recent evi...
Curve-fitting alone cannot validate neutral theory
Calcineurin goes to sleep
Sex ratio drive in mice: A binding competition between sex-linked genes
Recessive genetic contribution to congenital heart disease in 5,424 probands
Variants with large effect contribute to congenital heart disease (CHD). To date, recessive genotypes (RGs) have commonly been implicated through anecdotal ascertainment of consanguineous families and...
A cosmopolitan calcifying benthic foraminifera in agglutinated disguise as a geochemical recorder of coastal environments
Calcifying foraminifera from the orders Rotaliida and Miliolida are widely used as geochemical proxies for recording paleoceanographic conditions, while agglutinated foraminifera are often overlooked...
Potential limiting factor on engaged research: Academic evaluation systems
Genomic divergence across the tree of life
Nucleotide sequence data are being harnessed to identify species, even in cases in which organisms themselves are neither in hand nor witnessed. But how genome-wide sequence divergence maps to species...
Correction for Qin et al., A signaling molecule from intratumor bacteria promotes trastuzumab resistance in breast cancer cells
Reply to Ye: Parallel progress in funder practices and expansion of academic incentives to support engaged research
Deep learning to quantify the pace of brain aging in relation to neurocognitive changes
Brain age (BA), distinct from chronological age (CA), can be estimated from MRIs to evaluate neuroanatomic aging in cognitively normal (CN) individuals. BA, however, is a cross-sectional measure that...