Proceedings of the National Academy of Sciences
Articles in this Issue
Logic-based machine learning predicts how escitalopram attenuates cardiomyocyte hypertrophy
Cardiomyocyte hypertrophy is a key clinical predictor of heart failure. High-throughput and AI-driven screens have the potential to identify drugs and downstream pathways that modulate cardiomyocyte h...
On the shape of air bubbles trapped in ice
Water usually contains dissolved gases, and because freezing is a purifying process these gases must be expelled for ice to form. Bubbles appear at the freezing front and are then trapped in ice, maki...
Effects of binding partners on thermal reversion rates of photoswitchable molecules
The binding of photoswitchable molecules to partners forms the basis of many naturally occurring light-dependent signaling pathways and various photopharmacological and optogenetic tools. A critical p...
Environmental justice beyond race: Skin tone and exposure to air pollution
Recent research, focused mostly on the United States and Western Europe, shows that marginalized communities often face greater environmental degradation. However, the ethnoracial categories used in t...
Decoding planetary surfaces by counting cracks
Planets are often covered with thin cracked shells. From mud films to lithospheres of rock or ice, fracture networks form two-dimensional (2D) tessellations of convex polygons whose geometry encodes t...
Prodrug activation in malaria parasites mediated by an imported erythrocyte esterase, acylpeptide hydrolase (APEH)
The continued emergence of antimalarial drug resistance highlights the need to develop new antimalarial therapies. Unfortunately, new drug development is often hampered by undesirable drug-like proper...
A simple, statistically robust test of discrimination
In observational studies of discrimination, the most common statistical approaches consider either the rate at which decisions are made (benchmark tests) or the success rate of those decisions (outcom...
Coronavirus endoribonuclease antagonizes ZBP1-mediated necroptosis and delays multiple cell death pathways
Identifying conserved mechanisms used by viruses to delay host innate responses can reveal potential targets for antiviral therapeutics. Here, we investigated coronavirus nonstructural protein 15 (nsp...
RNA-targeted proteomics identifies YBX1 as critical for efficient HCMV mRNA translation
Viruses have evolved unique strategies to circumvent host control of protein synthesis and enable viral protein synthesis in the face of the host response. Defining the factors that regulate viral mes...
Cas9-mediated gene-editing frequency in microalgae is doubled by harnessing the interaction between importin α and phytopathogenic NLSs
Pathogen-derived nuclear localization signals (NLSs) enable vigorous nuclear invasion in the host by the virulence proteins harboring them. Herein, inspired by the robust nuclear import mechanism, we...
Photoreduction of mercuric bromides in polar ice
In the polar regions, which are vulnerable receptors of mercury pollution, atmospheric mercury depletion events (AMDEs) efficiently convert elemental mercury (Hg(0)) into oxidized mercury (Hg(II)) via...
TEX38 localizes ZDHHC19 to the plasma membrane and regulates sperm head morphogenesis in mice
Sperm morphogenesis is a tightly regulated differentiation process, disruption of which leads to sperm malfunction and male infertility. Here, we show that Tex38...
Archaeology and traversing America’s pre-Columbian fault line
Copy number variation contributes to parallel local adaptation in an invasive plant
Adaptation is a critical determinant of the diversification, persistence, and geographic range limits of species. Yet the genetic basis of adaptation is often unknown and potentially underpinned by a...
Prediction of carbon nanostructure mechanical properties and the role of defects using machine learning
Graphene-based nanostructures hold immense potential as strong and lightweight materials, however, their mechanical properties such as modulus and strength are difficult to fully exploit due to challe...
Resilient tree-planting strategies for carbon dioxide removal under compounding climate and economic uncertainties
To meet decarbonization targets, nations around the globe have made ambitious commitments to expand forested land. Operationalizing these commitments requires choosing a planting strategy: How many tr...
In the activation of HPV-specific human B cells HPV-VLP vaccines mimic membrane-associated antigens
B cell responses to membrane-presented antigens appear to be strongly favored over soluble antigens in vivo suggesting that vaccines that mimic membrane-presented antigens may be highly efficacious. W...
Environmental drivers of spatial variation in tropical forest canopy height: Insights from NASA’s GEDI spaceborne LiDAR
Forest canopy height is a fundamental ecosystem property—influencing patterns of forest carbon storage and forest ecosystem responses to climate variability and change. Previous studies have analyzed...
Cluster dynamical mean-field study of intra-unit-cell charge nematicity in hole-doped cuprates
Recent scanning-tunneling microscopy on hole-doped Bi 2...
Stereospecific control of microbial growth by a combinatoric suite of chiral siderophores
Bacteria compete for iron by producing small-molecule chelators known as siderophores. The triscatechol siderophores trivanchrobactin and ruckerbactin, produced by Vibrio campbelli...
Independent and combined effects of long-term air pollution exposure and genetic predisposition on COVID-19 severity: A population-based cohort study
The relationships between air pollution, genetic susceptibility, and COVID-19-related outcomes, as well as the potential interplays between air pollution and genetic susceptibility, remain largely une...
Inhibition of amyloid beta oligomer accumulation by NU-9: A unifying mechanism for the treatment of neurodegenerative diseases
Protein aggregation is a hallmark of neurodegenerative diseases, which connects these neuropathologies by a common phenotype. Various proteins and peptides form aggregates that are poorly degraded, an...
Reply to Johnson: Holistic evaluation of ecological models in paleobiology
Vimentin undergoes liquid–liquid phase separation to form droplets which wet and stabilize actin fibers
The cytoskeleton is composed of F-actin, microtubules, and intermediate filaments (IFs). Vimentin is one of the most ubiquitous and well-studied IFs. It is involved in many activities including wound...
Early evidence of avocado domestication from El Gigante Rockshelter, Honduras
Molecular research suggests that avocados ( Persea americana Mill.) were domesticated multiple times in the Americas. Seed exchange, hybridization, and cloning...