Proceedings of the National Academy of Sciences
Articles in this Issue
Climate change amplifies neurotoxic methylmercury threat to Asian fish consumers
Climate change is intricately influencing the accumulation of neurotoxic methylmercury (MeHg) in human food webs, potentially leading to uneven exposure risks across regions. Here, we reveal that clim...
A national megastudy shows that email nudges to elementary school teachers boost student math achievement, particularly when personalized
In response to the alarming recent decline in US math achievement, we conducted a national megastudy in which 140,461 elementary school teachers who collectively taught 2,992,027 students were randoml...
Competition response of cloud supersaturation explains diminished Twomey effect for smoky aerosol in the tropical Atlantic
The Twomey effect brightens clouds by increasing aerosol concentrations, which activates more droplets and decreases cloud supersaturation in response to more competition for water vapor. To quantify...
Targeted degradation of α-Synuclein using an evolved botulinum toxin protease
There is considerable interest in the targeted degradation of proteins implicated in human disease. The use of sequence-specific proteases for this purpose is severely limited by the difficulty in eng...
Control of circadian muscle glucose metabolism through the BMAL1–HIF axis in obesity
Disruptions of circadian rhythms are widespread in modern society and lead to accelerated and worsened symptoms of metabolic syndrome. In healthy mice, the circadian clock factor BMAL1 is required for...
Bacteria on steroids
Long-chain alkanes preserved in a Martian mudstone
Organic molecules preserved in ancient Martian rocks provide a critical record of the past habitability of Mars and could be chemical biosignatures. Experiments conducted by the Sample Analysis at Mar...
Correction for Magesh et al., Co-zorbs: Motile, multispecies biofilms aid transport of diverse bacterial species
Correction for Quach et al., Deep learning–driven bacterial cytological profiling to determine antimicrobial mechanisms in <i>Mycobacterium tuberculosis</i>
Correction to Supporting Information for Walters et al., Identification of FSH-regulated and estrous stage–specific transcriptional networks in mouse ovaries
Large language models for identifying social determinants of health
Correction to Supporting Information for Stransky et al., Toward a CRISPR-based mouse model of <i>Vhl</i> -deficient clear cell kidney cancer: Initial experience and lessons learned
Correction to Supporting Information for Struve et al., Systematic changes in circumpolar dust transport to the Subantarctic Pacific Ocean over the last two glacial cycles
Reply to Deter-Wolf et al.: Laser-stimulated fluorescence of Chancay tattoos
Laser imaging of ancient tattoos: New tools illuminate established knowledge
Reply to Wang: Improving large language model approaches for identifying social determinants of health from clinical notes
Xylem embolism refilling revealed in stems of a weedy grass
Plant hydraulic dysfunction by embolism formation can impair photosynthesis, growth, and reproduction and, in severe cases, lead to death. Embolism reversal, or “refilling,” is a hypothesized adaptive...
Correction to Supporting Information for Schmidt et al., Archaeological adhesives made from <i>Podocarpus</i> document innovative potential in the African Middle Stone Age
Correction to Supporting Information for Wang et al., Metabolomic insights into pathogenesis and therapeutic potential in adult acute lymphoblastic leukemia
Avian cranial kinesis is the result of increased encephalization during the origin of birds
The origin of birds represents a pivotal transition in vertebrate evolution, marked by significant changes in both brain size and feeding biomechanics. The evolution of the avian skull involved dramat...
Jellyfish shape as a mechanical balance
Why are jellyfish round? Animals get their shapes as they develop. After development, however, how animals keep their shapes is less understood. Moon jellies respond to perturbations to body shape, su...