Proceedings of the National Academy of Sciences
Articles in this Issue
Cytoplasmic Mg <sup>2+</sup> supersedes carbon source preference to dictate <i>Salmonella</i> metabolism
Glucose is the preferred carbon source of most studied microorganisms. However, we now report that glucose loses preferred status when the intracellular pathogen Salmonella enteric...
Correction for Ganguli et al., A culture-free biphasic approach for sensitive and rapid detection of pathogens in dried whole-blood matrix
Rolling vesicles: From confined rotational flows to surface-enabled motion
Friction forces are essential for cell movement, yet they also trigger numerous active cellular responses, complicating their measurement in vivo. Here, we introduce a synthetic model designed to meas...
Structure of ATP synthase from an early photosynthetic bacterium <i>Chloroflexus aurantiacus</i>
F-type ATP synthase (F 1 F O ) catalyzes proton motive force-driven ATP synthesis in mitochondria, chloroplasts, and bac...
Matrix degradation enhances stress relaxation, regulating cell adhesion and spreading
In native extracellular matrices (ECM), cells utilize matrix metalloproteinases (MMPs) to degrade and remodel their microenvironment. Accordingly, synthetic matrices have been engineered to permit MMP...
Most Christian American religious leaders silently believe in climate change, and informing their congregation can help open dialogue
Religious leaders shape the attitudes and beliefs of their congregations. In a nationally representative sample of U.S. religious leaders ( N = 1,600), the majo...
Acute TREM2 inhibition depletes MAFB-high microglia and hinders remyelination
We investigated the role of Triggering Receptor Expressed on Myeloid cells 2 (TREM2) in myelin regeneration in the brain. TREM2 is a receptor that activates microglia, which are crucial for clearing m...
De novo discovery of a molecular glue–like macrocyclic peptide that induces MCL1 homodimerization
Macrocyclic peptides have emerged as promising drug candidates, filling the gap between small molecules and large biomolecules in drug discovery. The antiapoptotic protein myeloid cell leukemia 1 (MCL...
Prediction of phase-separation propensities of disordered proteins from sequence
Phase separation is one possible mechanism governing the selective cellular enrichment of biomolecular constituents for processes such as transcriptional activation, mRNA regulation, and immune signal...
The visuomotor transformations underlying target-directed behavior
The visual system can process diverse stimuli and make the decision to execute appropriate behaviors, but it remains unclear where and how this transformation takes place. Innate visually evoked behav...
Neural basis for individual differences in the attention-enhancing effects of methylphenidate
Stimulant drugs that boost dopamine, like methylphenidate (MP), enhance attention and are effective treatments for attention-deficit hyperactivity disorder (ADHD). Yet there is large individual variat...
The narrow search effect and how broadening search promotes belief updating
Information search platforms, from Google to AI-assisted search engines, have transformed information access but may fail to promote a shared factual foundation. We demonstrate that the combination of...
Revealing the roles of the solid–electrolyte interphase in designing stable, fast-charging, low-temperature Li-ion batteries
Designing the solid–electrolyte interphase (SEI) is critical for stable, fast-charging, low-temperature Li-ion batteries. Fostering a “fluorinated interphase,” SEI enriched with LiF, has become a popu...
Adaptive ATP-induced molecular condensation in membranized protocells
Liquid–liquid phase separation (LLPS) has been achieved in various cytomimetic (protocell) models, but controlling molecular condensation using noninert crowders to systematically alter protocell func...
Magnetic suppression of quantum tunneling: Insights from Fefferman, Shapiro, and Weinstein
Superficial auditory (dis)fluency biases higher-level social judgment
When talking to other people, we naturally form impressions based not only on what they say but also on how they say it—e.g., how confident they sound. In modern life, however, the sounds of voices ar...
Lysosomal PIP <sub>3</sub> revealed by genetically encoded lipid biosensors
3-Phosphoinositides (3-PIs), phosphatidylinositol (3,4) bisphosphate [PI(3,4)P 2 ] and phosphatidylinositol (3,4,5) trisphosphate (PIP 3...
Large-scale combination screens reveal small-molecule sensitization of antibiotic-resistant gram-negative ESKAPE pathogens
Antibiotic resistance, especially in multidrug-resistant ESKAPE pathogens, remains a worldwide problem. Combination antimicrobial therapies may be an important strategy to overcome resistance and broa...
Social control drove ant evolution
The FBXW7–KMT2 axis in cancer-associated fibroblasts controls tumor growth via an epigenetic-paracrine mechanism
F-box and WD repeat domain-containing 7 (FBXW7) is a tumor suppressor that targets various oncoproteins for degradation, but its role in modulating cancer-associated fibroblasts (CAFs) in the tumor mi...
Using net-zero carbon debt to track climate overshoot responsibility
Current emissions trends will likely deplete a 1.5 °C consistent carbon budget around the year 2030, resulting in at least a temporary exceedance, or overshoot. To clarify responsibilities for this bu...
Genomic analysis of 11,555 probands identifies 60 dominant congenital heart disease genes
Congenital heart disease (CHD) is a leading cause of infant mortality. We analyzed de novo mutations (DNMs) and very rare transmitted/unphased damaging variants in 248 prespecified genes in 11,555 CHD...
Nanosilica supplementation in tomato increases oviposition on stems and caterpillar mortality in the tomato pinworm
Silicon-induced responses play a key role in plant defense against herbivory, though the underlying mechanisms remain underexplored. In this study, we examined how mesoporous silica nanoparticles (MSN...
Central TYK2 inhibition identifies TYK2 as a key neuroimmune modulator
GWAS have identified tyrosine kinase 2 (TYK2) variants in multiple inflammatory disorders, specifically a protective hypomorphic TYK2 allele (P1104A) in multiple sclerosis (MS). Impaired TYK2 signalin...