Proceedings of the National Academy of Sciences
Articles in this Issue
Correction for Wang et al., Unusual magnetotransport in twisted bilayer graphene from strain-induced open Fermi surfaces
Trophic convergence of marine vertebrate communities worldwide
Biogeographic regions arise due to constraints on species ranges, fostering lineage divergence as a result. Yet, convergent evolution means that evolutionary distinct lineages can share similar charac...
Prevalence of simplex compression in adversarial deep neural networks
Neural collapse (NC) reveals that the last layer of the network can capture data representations, leading to similar outputs for examples within the same class, while outputs for examples from differe...
Correction for Piacentino et al., Temporal changes in plasma membrane lipid content induce endocytosis to regulate developmental epithelial-to-mesenchymal transition
Correction for Zhou et al., tRNA selectivity during ribosome-associated quality control regulates the critical sterility-inducing temperature in two-line hybrid rice
Biofilm architecture determines the dissemination of conjugative plasmids
Plasmid conjugation is a contact-dependent horizontal gene transfer mechanism that significantly contributes to the dissemination of antibiotic resistance among bacteria. While the molecular mechanism...
Host use drives convergent evolution in clownfish
Clownfishes (Amphiprioninae) are a fascinating example of a marine radiation. From a central Pacific ancestor, they quickly colonized the coral reefs of the Indo-Pacific and diversified independently...
Comparative analysis of STP6 and STP10 unravels molecular selectivity in sugar transport proteins
The distribution of sugars is crucial for plant energy, signaling, and defense mechanisms. Sugar Transport Proteins (STPs) are Sugar Porters (SPs) that mediate proton-driven cellular uptake of glucose...
Lab earthquakes reveal a wide range of rupture behaviors controlled by fault bends
Natural faults are typically nonplanar and exhibit multiple bends, which deviate from the general fault orientation at different angles. However, while such deviations are considered a key factor cont...
Correction for Mukhi et al., Perception of structurally distinct effectors by the integrated WRKY domain of a plant immune receptor
Dynamical-generative downscaling of climate model ensembles
Regional high-resolution climate projections are crucial for many applications, such as agriculture, hydrology, and natural hazard risk assessment. Dynamical downscaling, the state-of-the-art method t...
Mechanism of read-through enhancement by aminoglycosides and mefloquine
Nonsense mutations are associated with numerous and diverse pathologies, yet effective treatment strategies remain elusive. A promising approach to combat these conditions involves the use of aminogly...
Morphogenesis of spin cycloids in a noncollinear antiferromagnet
Pattern formation in spin systems with continuous-rotational symmetry (CRS) provides a powerful platform to study emergent complex magnetic phases and topological defects in condensed-matter physics....
Molecular organization of central cholinergic synapses
Synapses have undergone significant diversification and adaptation, contributing to the complexity of the central nervous system. Understanding their molecular architecture is essential for decipherin...
Infrared light stimulates the cochlea through a mechanical displacement detected and amplified by hair cells
Although cochlear implants (CI) are the standard of care for profound sensorineural hearing loss they are technically constrained by the tendency of electrical current to spread within the fluid-fille...
Subunit specialization in AAA+ proteins and substrate unfolding during transcription complex remodeling
Bacterial RNA polymerase (RNAP) is a multisubunit enzyme that copies DNA into RNA in a process known as transcription. Bacteria use σ factors to recruit RNAP to promoter regions of genes that need to...
Evolutionary feedbacks for <i>Drosophila</i> aggression revealed through experimental evolution
Evolutionary feedbacks occur when evolution in one generation alters the environment experienced by subsequent generations and are an expected result of indirect genetic effects (IGEs). Hypotheses abo...
Disentangling conduction pathways at the ionic–electronic interface in EMI-TFSI-covered graphene transistors
Transport of electrons and ions at carbon surfaces immersed in electrolytes is instrumental for a wide variety of membrane processes as well as energy storage in batteries and supercapacitors. Ion tra...
Patulin and Xestoquinol are inhibitors of DNA topoisomerase 1
DNA topoisomerase 1 (TOP1) is essential for transcription, replication, and repair. Its function relies on two catalytic steps, DNA breakage and rejoining. Inhibitors of the second step prevent DNA re...
Bounded dissipation law and profiles of turbulent velocity moments in wall flows
Understanding the effects of solid boundaries on turbulent fluctuations remains a long-standing challenge. Available data on mean-square fluctuations in these flows show apparent contradiction with cl...
Conserved C143 forms a branched intermediate in Hedgehog autoprocessing: A cancer drug discovery target against Hedgehog signaling
Hedgehog (Hh) signaling plays fundamental roles in embryonic development while its abnormal activation in adults is associated with cancer. Hh targeting drugs have gained FDA approval but resistance e...
Mixing individual and collective behaviors to predict out-of-routine mobility
Predicting human displacements is crucial for addressing various societal challenges, including urban design, traffic congestion, epidemic management, and migration dynamics. While predictive models l...
Distinct oxytocin signaling pathways synergistically mediate rescue-like behavior in mice
Spontaneous rescue behavior enhances the well-being and survival of social animals, yet the neural mechanisms underlying the recognition and response to conspecifics in need remain unclear. Here, we r...
The tilt illusion arises from an efficient reallocation of neural coding resources at the contextual boundary
The tilt illusion—a bias in the perceived orientation of a center stimulus induced by an oriented surround—illustrates how context shapes visual perception. Although extensively studied for decades, w...
Pathogen growth and virulence dynamics drive the host evolution against coinfections
The occurrence of coinfections, where hosts are simultaneously infected by multiple pathogens, is widespread in nature and has significant negative impacts on global health. In humans, over one-sixth...