Proceedings of the National Academy of Sciences
Articles in this Issue
PPARα regulates ER–lipid droplet protein Calsyntenin-3β to promote ketogenesis in hepatocytes
Ketogenesis requires fatty acid flux from intracellular (lipid droplets) and extrahepatic (adipose tissue) lipid stores to hepatocyte mitochondria. However, whether interorganelle contact sites regula...
Computational analysis of 100 K choice dilemmas: Decision attributes, trade-off structures, and model-based prediction
We present a dataset of over 100 K textual descriptions of real-life choice dilemmas, obtained from social media posts and large-scale survey data. Using large language models (LLMs), we extract hundr...
Phase transitions and dimensional cross-over in layered confined solids
The nature of solid phases and cross-over of order–disorder phase transitions from two-dimensional (2D) layers to three-dimensional (3D) bulk in confined atomic systems remain largely unexplained. To...
Rab32 regulates Golgi structure and cell migration through Protein Kinase A–mediated phosphorylation of Optineurin
Rab32 is a small GTPase and molecular switch implicated in vesicular trafficking. Rab32 is also an A-Kinase Anchoring Protein (AKAP), which anchors cAMP-dependent Protein Kinase (PKA) to specific subc...
An algorithmic constraint at the transition to complex life
Nonnative tree invaders lead to declines in native tree species richness
Biological invasions are profoundly altering Earth’s ecosystems, but generalities about the effects of nonnative species on the diversity and productivity of native communities have been elusive. This...
The ins and outs of plant specialized metabolite gene organization
Ecologically informed solar enables a sustainable energy transition in US croplands
United States (US) croplands are ideal recipient environments for solar photovoltaic (PV) energy because they are flat and have a high solar resource. Perceived threats of solar to agriculture have le...
PEARLs of wisdom for ribosome-independent peptide bond synthesis
Abiotic origin of the citric acid cycle intermediates
The molecular framework for protometabolism—chemical reactions in a prebiotic environment preceding modern metabolism—has remained unknown in evolutionary biology. Mono-, di-, and tricarboxylic acids...
Identifying air quality monitoring deserts in the United States
Air quality is associated with adverse health outcomes and mortality risk. While most research has focused on the association between air quality estimates and these outcomes, little is known about th...
Structure in conversation: Evidence for the vocabulary, semantics, and syntax of prosody
Prosody, the musical facet of speech, is pivotal in human communication, and its structure and meaning remain subjects of ongoing research. In this study, we introduce a data-driven model for English...
Mitigation justice
Mitigating climate change and social injustice are critical, interwoven challenges. Climate change is driven by grossly unequal contributions to elevated greenhouse gas emissions among individuals, so...
Linking energetic instability to compositional changes in biological communities
The resilience of an ecological community informs us how it will respond to future environmental disturbances. However, the concept is rarely tested in the context of predicting biodiversity change, p...
Mapping the developmental profile of ventricular zone–derived neurons in the human cerebellum
The cerebellar ventricular zone (VZ) is the primary source of progenitors that generate cerebellar GABAergic neurons, including Purkinje cells (PCs) and interneurons (INs). This study provides detaile...