Proceedings of the National Academy of Sciences
Articles in this Issue
Widespread thiamine deficiency in California salmon linked to an anchovy-dominated marine prey base
Thiamine (vitamin B 1 ) deficiency in marine systems is a globally significant threat to marine life. In 2020, newly hatched Chinook salmon (...
Early warning signs of salt marsh drowning indicated by widespread vulnerability from declining belowground plant biomass
Salt marshes provide valuable ecosystem services but are vulnerable to drowning with accelerated sea-level rise (SLR). Marsh belowground biomass (BGB) production helps avoid drowning by building marsh...
Big evolutionary fireworks in tiny glass houses
High tree diversity exposed to unprecedented macroclimatic conditions even under minimal anthropogenic climate change
Tree species worldwide face increasing exposure to unprecedented macroclimatic conditions due to anthropogenic climate change, which may trigger biome shifts and ecosystem disruptions. We quantified c...
JunB–HBZ nuclear translocation by TGF-β is a key driver in HTLV-1-mediated leukemogenesis
The HTLV-1 bZIP factor ( HBZ ) gene, which is the only viral gene conserved and consistently expressed in all adult T-ce...
SARS-CoV-2 nucleocapsid protein directly prevents cGAS–DNA recognition through competitive binding
A hallmark of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is the delayed interferon response. Interferons are typically produced upon host recognition of pathogen- or damage...
Inhibiting Nav1.8 for pain: Lessons from patients and from neurons
The role of estrogen receptor β in maintaining basal cells and modulating the immune environment in the prostate
Estrogen receptor β (ERβ) plays an important role in both the mouse and human prostate. The endogenous ligand for ERβ is the dihydrotestosterone metabolite, 5β-androstane-3β, 17β-diol (3β-Adiol). Thus...
Bone morphogenetic protein-9 controls pulmonary vascular growth and remodeling
Pulmonary arterial hypertension (PAH) and hereditary hemorrhagic telangiectasia (HHT) are two distinct vascular diseases linked to impaired signaling through bone morphogenetic protein (BMP) receptor...
Molecular contacts in self-assembling clusters of membrane proteins
Motivated by recent data pointing to the existence of homo-oligomeric assemblies of membrane proteins called higher-order transient structures, and their apparent role in connecting components of memb...
An ABA–ROP toggle switch orchestrates xylem differentiation and cell wall patterning
The mutual antagonistic signaling of abscisic acid (ABA) and ROP GTPases highlights an intersection between stress responses and pattern formation. Previously, we have shown that signaling of ABA in t...
Genetic contributions to brain criticality and its relationship with human cognitive functions
Recently, extensive evidence has demonstrated that the brain operates close to a critical state, characterized by dynamic patterns known as neuronal avalanches. The critical state, reflecting the deli...
Immune cell profiling reveals diverse niches of immune residents of the enteric nervous system and potential neuroimmune interactions
Gastrointestinal (GI) neuroimmune interactions are crucial sensors and regulators of tissue homeostasis. Most enteric neurons reside within the myenteric plexus of the enteric nervous system in the mu...
Winters restrict a climate change–driven butterfly range expansion despite rapid evolution of seasonal timing traits
Climate change pushes species toward higher latitudes and altitudes, but the proximate drivers of range expansions vary, and it is unclear whether evolution facilitates climate change–induced range ch...
Correction for Zhang et al., Dancr-BRG1 regulates Nfatc1 transcription and Pgc1β-dependent metabolic shifts in osteoclastogenesis
Correction for Smith et al., A twist grain boundary phase in aqueous solutions of the nucleic acid tetramer GTAC
Correction for Chihoub et al., The evolution of robustness and fragility during long-term bacterial adaptation
Correction for Maher et al., Intracranial substrates of meditation-induced neuromodulation in the amygdala and hippocampus
Methane-powered sea spiders: Diverse, epibiotic methanotrophs serve as a source of nutrition for deep-sea methane seep <i>Sericosura</i>
Methane seeps harbor uncharacterized animal–microbe symbioses with unique nutritional strategies. Three undescribed sea spider species (family Ammotheidae; genus Sericosura...