Proceedings of the National Academy of Sciences
Articles in this Issue
Global kinetic model of lipid-induced <i>α</i> -synuclein aggregation and its inhibition by small molecules
The aggregation of α -synuclein into amyloid fibrils is a hallmark of Parkinson’s disease. This process has been shown to directly involve interactions between...
Population structure limits the use of genomic data for predicting phenotypes and managing genetic resources in forest trees
There is overwhelming evidence that forest trees are locally adapted to climate. Thus, genecological models based on population phenotypes have been used to measure local adaptation, infer genetic mal...
Enhanced chloroplast FtsZ-ring constriction by the ARC6–ARC3 module in <i>Arabidopsis</i>
Chloroplast division, a process tightly linked to the energy demands of plants, is initiated by the formation of the stromal filamenting temperature-sensitive Z (FtsZ) ring. The Z ring is highly dynam...
Ena/VASP-EVH1 inhibition prevents chemotaxis and metastasis by blocking the EVH1–WAVE2 interaction
Cancer therapy would benefit from suppressing cancer cell motility in the process of metastasis. Such directed cell migration relies on the propulsive force established by the filamentous actin networ...
Genome-scale knockout simulation and clustering analysis of drug-resistant breast cancer cells reveal drug sensitization targets
Anticancer chemotherapy is an essential part of cancer treatment, but the emergence of resistance remains a major hurdle. Metabolic reprogramming is a notable phenotype associated with the acquisition...
On the mechanism of photodriven hydrogenations of N <sub>2</sub> and other substrates by Hantzsch ester: Buffer is key to reactive H-atom donors
The Hantzsch ester (HEH 2 ) has found considerable utility as a photoreductant in synthesis, with photodriven transfer hydrogenation reactions typically limited...
Sensory population activity reveals downstream confidence computations in the primate visual system
Perception is fallible. Humans know this, and so do some nonhuman animals like macaque monkeys. When monkeys report more confidence in a perceptual decision, that decision is more likely to be correct...
Roughness-dependent scaling of the contact area and separation gap with pressure for glassy polymers
The contact between two rough surfaces has been a topic of significant interest since early studies on Coulombic friction and remains crucial for numerous technological applications. However, theoreti...
The RRM domain–containing protein Rbp3 interacts with ribosomes and the 3’ ends of mRNAs encoding photosynthesis proteins
RNA recognition motif (RRM) domain proteins are crucial RNA-binding proteins across all domains of life. In cyanobacteria, single RRM domain proteins are involved in mRNA targeting to the thylakoid me...
Pressure-driven electronegativity inversion in alkali liquids
Liquid–liquid phase transitions (LLPTs) are typically characterized as two-state systems, where transitions occur between two distinct liquid phases driven by local structural rearrangements. In this...
<i>PIK3CA</i> gain-of-function mutation in Schwann cells leads to severe neuropathy and aerobic glycolysis through a non-cell autonomous effect
PIK3CA -related disorders are rare genetic disorders due to somatic gain-of-function mutations in PIK3CA during embryonic development, a pat...
S-adenosylmethionine metabolism buffering is regulated by a decrease in glycine N-methyltransferase via the nuclear ubiquitin–proteasome system
Metabolic homeostasis is essential for survival; however, many studies have focused on the fluctuations of these factors. Furthermore, while metabolic homeostasis depends on the balance between the pr...
In situ NMR reveals a pH sensor motif in an outer membrane protein that drives bacterial vesicle production
The outer membrane vesicles (OMVs) produced by diderm bacteria have important roles in cell envelope homeostasis, secretion, interbacterial communication, and pathogenesis. The facultative intracellul...
The importance of small-island populations for the long-term survival of endangered large-bodied insular mammals
Island populations of large vertebrates have experienced higher extinction rates than mainland populations over long timescales due to demographic stochasticity, genetic drift, and inbreeding. While b...
Setdb1 ablation in macrophages attenuates fibrosis in heart allografts
Tissue fibrosis is commonly associated with organ malfunction and is strongly associated with the development of chronic rejection, cardiovascular diseases, and other chronic diseases. Fibrosis also c...
Repeated occurrences of marine anoxia under high atmospheric O <sub>2</sub> and icehouse conditions
The Late Paleozoic Ice Age (~340 to 260 Ma) occurred under peak atmospheric O 2 (1.2 to 1.7 PIAL, pre-industrial atmospheric levels) for Earth history and CO...
A bioinspired and degradable riboflavin-containing polypeptide as a sustainable material for energy storage
Inspired by Nature, we present a polypeptide-based organic redox-active material constructed from renewable feedstocks, L-glutamic acid (an amino acid) and riboflavin (vitamin B 2...
EIAV encodes an accessory protein that antagonizes the host restriction factor equine tetherin
Equine infectious anemia virus (EIAV) is an important model for the study of pathogenesis in lentiviruses. Studies of viral genome organization and replication mechanisms are fundamental to the unders...
Women climate scientists are connected, productive, and successful but have shorter careers
Scholars have long been concerned about gender representation in scientific research but there has been little work on gender differences in participation and performance in climate science, a field t...
Spatial metabolomics informs the use of clinical imaging for improved detection of cribriform prostate cancer
Cribriform prostate cancer (crPCa) is associated with poor clinical outcomes, yet its accurate detection remains challenging due to the poor sensitivity of standard-of-care diagnostic tools. Here, we...
Cenozoic geoclimatic changes drove the evolutionary dynamics of floristic endemism on the Qinghai–Tibet Plateau
The Qinghai–Tibet Plateau (QTP) harbors extraordinarily high levels of biodiversity and endemism. The region is warming at a rate twice the global average, yet the evolutionary dynamics of its unique...
Global overlooked multidimensional water scarcity
Freshwater resources are fundamental to supporting humanity, and measures of water scarcity have been critical for identifying where water requirements and water availability are imbalanced. Existing...
Calcineurin targets that mediate <i>Cryptococcus</i> thermotolerance
Institutions of public judgment established by social contract and taxation
Indirect reciprocity is a compelling explanation for stable cooperation in a large society: Those who cooperate appropriately earn a good standing, so that others are more likely to cooperate with the...
Structural mechanism for the recognition of E2F1 by the ubiquitin ligase adaptor Cyclin F
Cyclin F, a noncanonical member of the cyclin protein family, plays a critical role in regulating transitions in the cell division cycle. Unlike canonical cyclins, which bind and activate cyclin-depen...