Widespread thiamine deficiency in California salmon linked to an anchovy-dominated marine prey base

N Nathan J. Mantua (National Oceanic and Atmospheric Administration (NOAA) Fisheries, Southwest Fisheries Science Center, Fisheries Ecology Division) H Heather Bell (Department of Wildlife, Fish and Conservation Biology, University of California) A Anne E. Todgham (Department of Animal Science, University of California) M Miles E. Daniels (National Oceanic and Atmospheric Administration (NOAA) Fisheries, Southwest Fisheries Science Center, Fisheries Ecology Division) J Jacques Rinchard (Department of Environmental Science and Ecology, State University of New York) J Jarrod M. Ludwig (Department of Environmental Science and Ecology, State University of New York) J John C. Field (National Oceanic and Atmospheric Administration (NOAA) Fisheries, Southwest Fisheries Science Center, Fisheries Ecology Division) S Steven T. Lindley (National Oceanic and Atmospheric Administration (NOAA) Fisheries, Southwest Fisheries Science Center, Fisheries Ecology Division) F Freya E. Rowland (U.S. Geological Survey, Columbia Environmental Research Center, Department of Interior) C Catherine A. Richter (U.S. Geological Survey, Columbia Environmental Research Center, Department of Interior) D David Walters (U.S. Geological Survey, Columbia Environmental Research Center, Department of Interior) B Bruce Finney (Department of Geosciences, Idaho State University) H Haskell Anne R. Distajo (Department of Biological Sciences, Idaho State University) D Donald Tillitt (U.S. Geological Survey, Columbia Environmental Research Center, Department of Interior) D Dale C. Honeyfield (Retired U.S. Geological Survey, Eastern Ecological Science Center) T Taylor Lipscomb (California-Nevada Fish Health Center, U.S. Fish and Wildlife Service) K Kevin Kwak (Fisheries Branch, California Department of Fish and Game) J Jason Kindopp (Division of Integrated Science and Engineering, California Department of Water Resources) D Dennis Cocherell (Department of Wildlife, Fish and Conservation Biology, University of California) A Abigail Ward (Department of Wildlife, Fish and Conservation Biology, University of California) T Thomas H. Williams (National Oceanic and Atmospheric Administration (NOAA) Fisheries, Southwest Fisheries Science Center, Fisheries Ecology Division) J Jeff Harding (National Oceanic and Atmospheric Administration (NOAA) Fisheries, Southwest Fisheries Science Center, Fisheries Ecology Division) N Nann A. Fangue (Department of Wildlife, Fish and Conservation Biology, University of California) C Carson Jeffres (Center for Watershed Sciences, University of California) R Rocio I. Ruiz-Cooley (Ensenada Center for Scientific and Higher Education) S Steven Y. Litvin (Monterey Bay Aquarium Institute) S Scott Foott (California-Nevada Fish Health Center, U.S. Fish and Wildlife Service) M Mark Adkison (Fisheries Branch, California Department of Fish and Game) B Brett Kormos (Fisheries Branch, California Department of Fish and Game) P Peggy Harte (Center for Community and Citizen Science, University of California) F Frederick Colwell (Department of Microbiology, Oregon State University) C Christopher P. Suffridge (Department of Microbiology, Oregon State University) K Kelly C. Shannon (Department of Microbiology, Oregon State University) A Amanda Cranford (National Oceanic and Atmospheric Administration (NOAA) Fisheries West Coast Region, California Central Valley Office) C Charlotte Ambrose (National Oceanic and Atmospheric Administration (NOAA) Fisheries West Coast Region, California Central Valley Office) A Aimee Reed (Oregon Department of Fish and Wildlife) R Rachel C. Johnson (National Oceanic and Atmospheric Administration (NOAA) Fisheries, Southwest Fisheries Science Center, Fisheries Ecology Division)

Abstract

Thiamine (vitamin B 1 ) deficiency in marine systems is a globally significant threat to marine life. In 2020, newly hatched Chinook salmon ( Oncorhynchus tshawytscha ) fry in California’s Central Valley (CCV) hatcheries swam in corkscrew patterns and died at unusually high rates due to a lack of this essential vitamin. We subsequently investigated the impacts and causes of thiamine deficiency in California’s anadromous salmonids. Our laboratory studies defined the relationship between thiamine concentrations in Chinook salmon eggs and early life-stage survival in offspring; we used these data to develop a model that estimated 26 to 48% thiamine-dependent fry mortality across consecutive years (2020–2021) for winter-run Chinook salmon. We established an egg surveillance effort that found widespread thiamine deficiency in CCV Chinook salmon in 2020 and 2021, and emerging thiamine deficiency in Klamath River and Trinity River coho salmon ( Oncorhynchus kisutch ) in 2021. We determined that thiamine injections into adults raised egg thiamine concentrations above levels found to impact early life-stage survival and swimming behavior. Ocean surveys, prey nutrition, salmon gut contents, and stable isotope data link thiamine deficiency to an ocean diet dominated by a booming population of northern anchovy ( Engraulis mordax ). This forage fish had low thiamine, high lipid, and high thiaminase activity levels consistent with both a thiaminase and oxidative stress hypothesis for causing thiamine deficiency in California salmon. Our research suggests California’s already stressed anadromous salmonids will continue to be impacted by thiamine deficiency as long as their ocean forage base and diet are dominated by northern anchovy.

Article Details

Volume / Issue Vol. 122, Issue 26
Published July 01, 2025
ISSN 0027-8424
Publisher National Academy of Sciences

Authors (37)

N

Nathan J. Mantua

National Oceanic and Atmospheric Administration (NOAA) Fisheries, Southwest Fisheries Science Center, Fisheries Ecology Division

H

Heather Bell

Department of Wildlife, Fish and Conservation Biology, University of California

A

Anne E. Todgham

Department of Animal Science, University of California

M

Miles E. Daniels

National Oceanic and Atmospheric Administration (NOAA) Fisheries, Southwest Fisheries Science Center, Fisheries Ecology Division

J

Jacques Rinchard

Department of Environmental Science and Ecology, State University of New York

J

Jarrod M. Ludwig

Department of Environmental Science and Ecology, State University of New York

J

John C. Field

National Oceanic and Atmospheric Administration (NOAA) Fisheries, Southwest Fisheries Science Center, Fisheries Ecology Division

S

Steven T. Lindley

National Oceanic and Atmospheric Administration (NOAA) Fisheries, Southwest Fisheries Science Center, Fisheries Ecology Division

F

Freya E. Rowland

U.S. Geological Survey, Columbia Environmental Research Center, Department of Interior

C

Catherine A. Richter

U.S. Geological Survey, Columbia Environmental Research Center, Department of Interior

D

David Walters

U.S. Geological Survey, Columbia Environmental Research Center, Department of Interior

B

Bruce Finney

Department of Geosciences, Idaho State University

H

Haskell Anne R. Distajo

Department of Biological Sciences, Idaho State University

D

Donald Tillitt

U.S. Geological Survey, Columbia Environmental Research Center, Department of Interior

D

Dale C. Honeyfield

Retired U.S. Geological Survey, Eastern Ecological Science Center

T

Taylor Lipscomb

California-Nevada Fish Health Center, U.S. Fish and Wildlife Service

K

Kevin Kwak

Fisheries Branch, California Department of Fish and Game

J

Jason Kindopp

Division of Integrated Science and Engineering, California Department of Water Resources

D

Dennis Cocherell

Department of Wildlife, Fish and Conservation Biology, University of California

A

Abigail Ward

Department of Wildlife, Fish and Conservation Biology, University of California

T

Thomas H. Williams

National Oceanic and Atmospheric Administration (NOAA) Fisheries, Southwest Fisheries Science Center, Fisheries Ecology Division

J

Jeff Harding

National Oceanic and Atmospheric Administration (NOAA) Fisheries, Southwest Fisheries Science Center, Fisheries Ecology Division

N

Nann A. Fangue

Department of Wildlife, Fish and Conservation Biology, University of California

C

Carson Jeffres

Center for Watershed Sciences, University of California

R

Rocio I. Ruiz-Cooley

Ensenada Center for Scientific and Higher Education

S

Steven Y. Litvin

Monterey Bay Aquarium Institute

S

Scott Foott

California-Nevada Fish Health Center, U.S. Fish and Wildlife Service

M

Mark Adkison

Fisheries Branch, California Department of Fish and Game

B

Brett Kormos

Fisheries Branch, California Department of Fish and Game

P

Peggy Harte

Center for Community and Citizen Science, University of California

F

Frederick Colwell

Department of Microbiology, Oregon State University

C

Christopher P. Suffridge

Department of Microbiology, Oregon State University

K

Kelly C. Shannon

Department of Microbiology, Oregon State University

A

Amanda Cranford

National Oceanic and Atmospheric Administration (NOAA) Fisheries West Coast Region, California Central Valley Office

C

Charlotte Ambrose

National Oceanic and Atmospheric Administration (NOAA) Fisheries West Coast Region, California Central Valley Office

A

Aimee Reed

Oregon Department of Fish and Wildlife

R

Rachel C. Johnson

National Oceanic and Atmospheric Administration (NOAA) Fisheries, Southwest Fisheries Science Center, Fisheries Ecology Division