Proceedings of the National Academy of Sciences
Articles in this Issue
Tensor-based quantum phase difference estimation for large-scale demonstration
We develop an energy calculation algorithm leveraging quantum phase difference estimation (QPDE) scheme and a tensor-network-based unitary compression method in the preparation of superposition states...
Mechanistic insights into the iron–sulfur cluster-dependent interaction of the autophagy receptor NCOA4 with the E3 ligase HERC2
NCOA4, a dedicated autophagy receptor for mediating selective autophagy of ferritin (ferritinophagy), plays a vital role in maintaining cellular iron homeostasis. The cellular abundance of NCOA4 is re...
Optimal kinetics for catalytic cycles from a single path-sampling simulation
A catalyst’s efficiency for accelerating a reaction rate is determined by its molecular structure and interactions with the substrate. While one can predict kinetics for a particular molecular model,...
ATP synthesis driven by atmospheric hydrogen concentrations
All cells require a continuous supply of the universal energy currency, adenosine triphosphate (ATP), to drive countless cellular reactions. The universally conserved F 1...
The kinesin KIF3AC recycles endocytosed integrin to polarize new adhesion formation toward the leading edge
The recycling of integrin endocytosed during focal adhesion (FA) disassembly is critical for cell migration and contributes to the polarized formation of new FAs toward the leading edge. How this occu...
Kinetic pathways of solid–solid phase transitions dictated by short-range interactions
Structural phase transformations allow us to design materials from the ground up. Predicting the structural transformation of crystals during solid–solid phase transitions, however, is challenging, as...
Impact of women’s political empowerment through gender quotas on improved drinking water access in Africa
Access to safely managed drinking water is a fundamental human right, essential for human health and well-being. However, 2.2 billion people around the world still lack this access, with significant g...
Joanne Chory (1955–2024): Plant geneticist extraordinaire
Joanne Chory (1955–2024) was a pioneering biologist whose research transformed our understanding of plant growth and development. Her groundbreaking work, based on many clever genetic screens, establi...
Traveling waves link human visual and frontal cortex during working memory–guided behavior
Traveling waves guide the spatial propagation of neural activity and computational processes across the brain. Traveling waves could contribute to the control of memory-guided behaviors by flexibly or...
Correction for Richardson et al., A unifying principle for multispecies coexistence under resource fluctuations
Nucleation at solid–liquid interfaces is accompanied by the reconfiguration of electrical double layers
In electrochemical systems, the structure of electrical double layers (EDLs) near electrode surfaces is crucial for energy conversion and storage functions. While the electrodes in real-world systems...
Stress-induced translocation of the endoplasmic reticulum chaperone GRP78/BiP and its impact on human disease and therapy
Since their discoveries in the 1960s as a family of proteins produced by cells in response to stress, molecular chaperones are increasingly recognized as major regulators of cellular homeostasis in he...
Structure reveals a regulation mechanism of plant outward-rectifying K <sup>+</sup> channel GORK by structural rearrangements in the CNBD–Ankyrin bridge
Guard cells, which regulate stomatal apertures in plants, possess a sophisticated mechanism for regulating turgor pressure. The outward-rectifying “K + out...
Profile of Thomas Y. Hou
Working at the interface between numerics and applied analysis, Caltech mathematician Thomas Hou has solved challenging problems concerning fluid dynamics and other multiscale systems. His research ha...
Can we still use the Michaelis–Menten model for enzymatic microneedle sensors?
Since the 1960s, enzymatic sensors have been vital in healthcare and environmental monitoring due to their high selectivity. Traditionally, their performance is interpreted using the Michaelis–Menten...
Interfacial effects determine nonequilibrium phase behaviors in chemically driven fluids
Coupling between chemical fuel consumption and phase separation can lead to condensation at a nonequilibrium steady state, resulting in phase behaviors that are not described by equilibrium thermodyna...
Correction for Wang et al., The proofreading mechanism of the human leading-strand DNA polymerase ε holoenzyme
A multifunctional anti-O-Antigen human monoclonal antibody protects against <i>Shigella sonnei</i> infection in vivo
Shigellosis is a global public health challenge that mostly affects low- and middle-income countries and causes considerable morbidity and mortality among children under 5 y of age. Multi- and extensi...
SETDB1 ensures the continuity of embryonic to adult neural stem cells through metabolic alterations in the dentate gyrus
Embryonic neural progenitors give rise to adult neural stem cells (aNSCs), which share transcriptomic similarities with astrocytes while sustaining neurogenesis in the adult brain. How embryonic neura...
Implementation science aims to improve healthcare by validating effective interventions
Hydrogen cyanide and hydrocarbons mix on Titan
This work reveals a striking exception to the well-established rule in chemistry that polar and nonpolar compounds do not spontaneously mix: insertion of methane, ethane, and other small hydrocarbons...
Threonine phosphorylation of STAT1 safeguards gut epithelial integrity and restricts interferon-mediated cytotoxicity
Barrier tissues such as the intestine are constantly challenged by environmental stressors and must adapt to maintain integrity and prevent excessive inflammation. Although traditionally viewed as a p...
A quantitative figure of merit for battery SEI films and their use as functional solid-state electrolytes
As a key passivation film that governs battery operation, the solid electrolyte interphase (SEI) has long been credited for enabling high-performance batteries or blamed for their eventual death. Howe...
Human land use promotes range expansion of soil protists from temperate to subtropical regions in China
Land-use changes are reshaping the distribution of aboveground species worldwide. However, the impact of land-use changes on the distribution of soil organisms remains poorly understood. In particular...
The Gln-rich protein twip1 promotes high-density {110} twins formation in the shell of the limpet <i>Cellana rota</i>
Aragonite, a polymorph of calcium carbonate (CaCO 3 ), exhibits enhanced mechanical properties due to crystal defects such as twins, which are particularly prev...