Proceedings of the National Academy of Sciences
Articles in this Issue
Cellular cartography reveals mouse prostate organization and determinants of castration resistance
Inadequate response to androgen deprivation therapy (ADT) frequently arises in prostate cancer, driven by cellular mechanisms that remain poorly understood. Here, we integrated single-cell RNA sequenc...
The nonadaptive advantage: Why our brains can’t quit gaming
Interfacial electroneutrality controls transport of asymmetric salts through charge-patterned mosaic membranes
Membranes that selectively enhance target solute permeation while rejecting competing species are essential for precision separations. This study introduces charge-patterned mosaic membranes (CMMs) th...
Coordinated actions of NLR-assembled and glutamate receptor–like calcium channels in plant effector-triggered immunity
The plant immune system utilizes nucleotide-binding/leucine-rich repeat (NLR) proteins to detect pathogen virulence factors (effectors) inside host cells and transduce recognition to rapid defense. In...
An information-theoretic foreshadowing of mathematicians’ sudden insights
The “eureka” insights that drive progress in science and mathematics remain shrouded in mystery. Sudden, unexpected, appearing like “flashes of lightning”, these insights have the hallmarks of critica...