Proceedings of the National Academy of Sciences
Articles in this Issue
Abiotic synthesis during the interaction of ferrous chloride–rich silicic fluids with marble under high-grade metamorphic conditions
Ferrous chloride–rich silicic fluid and melt infiltration led to the decarbonation of dolomitic marble in the Chinese Sulu ultrahigh-pressure metamorphic terrain under temperatures ranging from 670 to...
Profile of Johannes Lehmann
Soil scientist Johannes Lehmann has spent his career examining how to improve soil quality to secure agricultural production, regulate climate, and keep water clean. His work with dark earths in the B...
Evolutionarily conserved grammar rules viral factories of amoeba-infecting members of the hyperdiverse <i>Nucleocytoviricota</i> phylum
Despite sharing fewer than 10 core genes, the hyperdiverse Nucleocytoviricota phylum (ranging from poxviruses to giant viruses) universally assembles viral fact...
The US–Israel Blavatnik Scientific Forum on alleviating global water scarcity by desalination and water reuse
Communication increases cooperation among students in a coordination game
Cooperation often requires individuals to balance personal risk with mutual gain. The Stag Hunt game provides a well-established paradigm for studying such decision-making. Prior research suggested th...
Precise antibody delivery to the brain via nanobubble-actuated focused ultrasound alleviates depression
Precise, noninvasive drug delivery to small but important brain regions is challenging and highly desired given the brain’s inherent complexity and heterogeneous nature. Here, we report an approach ut...
CRISPR with Transcriptional Readout reveals influenza transcription is modulated by NELF and can precipitate an interferon response
Transcription of interferons upon viral infection is critical for cell-intrinsic innate immunity. This process is influenced by many host and viral factors. To identify host factors that modulate inte...
Reply to Cummins et al.: GPT reveals cognitive dissonance that is both irrational and alarmingly humanlike
Cognitive dissonance in large language models is neither cognitive nor dissonant
To implement the Belém Declaration, we need a structured and collaborative approach
Early-life infectious disease exposure, the “hygiene hypothesis,” and lifespan: Evidence from hookworm disease
Exposure to infectious disease in early life may have long-term ramifications for health and lifespan. However, reducing pathogen exposure may not be uniformly beneficial. The rise of modern sanitatio...
Renormalization group for Anderson localization on high-dimensional lattices
We discuss the dependence of the critical properties of the Anderson model on the dimension d in the language of β -func...
Candidate Denisovan fossils identified through gene regulatory phenotyping
Denisovans are an extinct group of humans whose morphology is mostly unknown. The scarcity of verified Denisovan fossils makes it challenging to study their anatomy, and how well they were adapted to...
Logging disrupts the ecology of molecules in headwater streams
Global demand for wood products is increasing forest harvest. One understudied consequence of logging is that it accelerates mobilization of dissolved organic matter (DOM) from soils to aquatic ecosys...
Multistep catalytic abiotic CO <sub>2</sub> conversion to sugars through C <sub>1</sub> intermediates
Carbon dioxide (CO 2 ) to multicarbon (C n ) upgrading for commodity chemicals, fuel production, or artificial food synt...
Color-neutral and reversible tissue transparency enables longitudinal deep-tissue imaging in live mice
Light scattering in biological tissue presents a significant challenge for deep in vivo imaging. Our previous work demonstrated the ability to achieve optical transparency in live mice using intensely...
Tunable effective diffusion of CO <sub>2</sub> in aqueous foam
Aqueous foams are solid materials composed of gases and liquids, exhibiting a large gas/liquid surface area and enabling dynamic exchanges between their fluid components. The structure of binary-gas f...
STAGE: A compact and versatile TnpB-based genome editing toolkit for <i>Streptomyces</i>
Streptomyces are naturally endowed with the capacity to produce a wide array of natural products with biomedical and biotechnological value. They have garnered great interest in sy...
Specificities of chemosensory receptors in the human gut microbiota
The human gut is rich in metabolites and harbors a complex microbial community, yet surprisingly little is known about the spectrum of chemical signals detected by the large variety of sensory recepto...
Seeding of visceral adipose tissue with perinatally generated regulatory T cells shapes the metabolic tenor in mice
The Foxp3 + CD4 + regulatory T cells (Tregs) generated around birth are phenotypically and functionally distinct from th...
STIM1 transmembrane helix dimerization captured by AI-guided transition path sampling
Stromal interaction molecule 1 (STIM1) is a Ca 2+ -sensing protein in the endoplasmic reticulum (ER) membrane. The depletion of ER Ca 2+...
Ovarian germline stem cell dedifferentiation is cytoneme dependent
Progenitor cell dedifferentiation is important for stem cell maintenance during tissue repair and age-related stem cell decline. Here, we use the Drosophila ova...
Ice as a kinetic and mechanistic driver of oxalate-promoted iron oxyhydroxide dissolution
Ice often mediates unexpected reactions in the Cryosphere, acting as a fascinating geochemical reactor. Mineral–organic interactions in frozen environments, such as soils and permafrost, are crucial f...
An exploration of basic human values in 38 million obituaries over 30 years
How societies remember the dead can reveal what people value in life. We analyzed 38 million obituaries from the United States to examine how personal values are encoded in individual and collective l...
Mass support for conserving 30% of the Earth by 2030: Experimental evidence from five continents
Rapid global expansion of protected areas is critical for safeguarding biodiversity but depends on political action for successful implementation. Following widespread ratification of the Kunming-Mont...