Proceedings of the National Academy of Sciences
Articles in this Issue
Binding of <i>Fusobacterium nucleatum</i> autotransporter adhesin CbpF to human CEACAM1 and CEACAM5: A Velcro model for bacterium adhesion
In eukaryotic systems, three major types of cell junctions have been well characterized. While bacterial adhesion mechanisms also exhibit remarkable diversity, the molecular processes that regulate th...
Correction for Sharma and DiVincenzo, <i>g</i> -factor symmetry and topology in semiconductor band states
The RecBC complex protects single-stranded DNA gaps during lesion bypass
Following encounter with an unrepaired DNA lesion, replication is halted and can restart downstream of the lesion leading to the formation of a single-stranded DNA (ssDNA) gap. To complete replication...
Experimentally enhancing dispersal reveals the outsized importance of transient dynamics in a fluctuating environment
The size and composition of local species pools are, in part, determined by past dispersal events. Predicting how communities respond to future disturbances, such as fluctuating environmental conditio...
Correction for Gibbons et al., Motivational trade-offs and modulation of nociception in bumblebees
Replication stress–induced nuclear hypertrophy alters chromatin topology and impacts cancer cell fitness
Microscopic examination of biopsy tissues remains essential for cancer diagnosis, despite advancements in sequencing technologies. Alterations in nuclear size or the nuclear-to-cytoplasmic ratio are h...
The redox rhythm gates immune-induced cell death distinctly from the genetic clock
Organisms use circadian clocks to synchronize physiological processes to anticipate the Earth’s day-night cycles and regulate responses to environmental signals to gain competitive advantage. While di...
Bridging feeling and motion: Insula–premotor dynamics in the processing of action vitality forms
Typically, people perform actions in a valenced—positive or negative—way, depending on their attitudes or desires. These forms of action are named vitality forms (VFs). While it is well established th...
Could humans and AI become a new evolutionary individual?
Long-term evolutionary persistence of a cryptic color polymorphism in frogs
Color polymorphism can influence the evolutionary fate of cryptic species because it increases populations’ chances of survival in heterogenous or variable environments. Yet, little is known about the...
CpG-A induces liquid–liquid phase separation of HMGB1 to activate the RAGE-mediated inflammatory pathway
High-mobility group box protein 1 (HMGB1) is a chromatin-associated nonhistone protein widely distributed in the nucleus of eukaryotic cells. It is transported extracellularly as a proinflammatory med...
DNA polymerase α-primase can function as a translesion DNA polymerase
Replication of cellular chromosomes requires a primase to generate short RNA primers to initiate genomic replication. While bacterial and archaeal primase generate short RNA primers, the eukaryotic pr...
Is Nav1.8-specific inhibition the only path? Preferential Nav blockers offer a compelling alternative
Sensitization of cancer cells to DNA-damaging agents by expression of the REV1 C-terminal domain: Implications for chemotherapy
The mutagenic translesion synthesis (TLS) pathway, which is critically dependent on REV1’s ability to recruit inserter TLS polymerases and the POLζ extender polymerase, enables cancer cells to bypass...
Relationship dynamics and behavioral adaptations in the control of the 2022 mpox epidemic
We analyzed the patterns of transmission in the 2022 clade IIb mpox epidemic as it unfolded in the European population of men who have sex with men (MSM). We developed an agent-based model that simula...
Evolution of cross-tolerance to metals in yeast
Organisms often face multiple selective pressures simultaneously (e.g., mine tailings with multiple heavy metal contaminants), yet we know little about when adaptation to one stressor provides cross-t...
Critical exponents of the spin-glass transition in a field at zero temperature
We analyze the spin-glass transition in a field in finite dimension D...
Spontaneous glutamate release activates mGluR signaling to drive rapid antidepressant responses
Major depressive disorder affects millions worldwide, yet current treatments require prolonged administration. In contrast, ketamine produces rapid antidepressant effects by blocking spontaneous N-Met...
From molecular damage and viscoelasticity to interfacial fracture in soft polymer networks: Insights from mechanochemistry
Many soft, tough materials have emerged in recent years, paving the way for advances in wearable electronics, soft robotics, and flexible displays. However, understanding the interfacial fracture beha...
Measuring multisubunit mechanics of geometrically programmed colloidal assemblies via cryo-EM multi-body refinement
Programmable self-assembly has recently enabled the creation of complex structures through precise control of the interparticle interactions and the particle geometries. Targeting ever more structural...
Sorting nexin 3 promotes ischemic retinopathy through RIP1- and RIP3-mediated myeloid cell necroptosis and mitochondrial fission
Proliferative retinopathy is a leading cause of irreversible blindness in humans; however, the molecular mechanisms behind the immune cell–mediated retinal angiogenesis remain poorly elucidated. Here,...
Deep reinforcement learning control unlocks enhanced heat transfer in turbulent convection
Turbulent convection governs heat transport in both natural and industrial settings, yet optimizing it under extreme conditions remains a significant challenge. Traditional control strategies, such as...
A genetically encoded nanobody sensor reveals conformational diversity in β-arrestins orchestrated by distinct seven transmembrane receptors
Agonist-induced interaction of G protein–coupled receptors (GPCRs) with β-arrestins (βarrs) is a critical mechanism that regulates the spatiotemporal pattern of receptor localization and signaling. Wh...
Convergent evolution of <i>NFP</i> -facilitated root nodule symbiosis
The origin and phylogenetic distribution of symbiotic associations between nodulating angiosperms and nitrogen-fixing bacteria have long intrigued biologists. Recent comparative evolutionary analyses...
Stress-induced organismal death is genetically regulated by the mTOR–Zeste–Phae1 axis
All organisms are exposed to various stressors, which can sometimes lead to organismal death, depending on their intensity. While stress-induced organismal death has been observed in many species, the...