Proceedings of the National Academy of Sciences
Articles in this Issue
Microglia contribute to bipolar depression through Serinc2-dependent phospholipid synthesis
Although clinical research has revealed microglia-related inflammatory and immune responses in bipolar disorder (BD) patient brains, it remains unclear how microglia contribute to the pathogenesis of...
Adjusting the management of the Antarctic krill fishery to meet the challenges of the 21st century
Antarctic krill ( Euphausia superba ) is the central prey species in the Southern Ocean food web, supporting the largest and fastest-growing fishery in the regi...
Wild, scenic, and toxic: Recent degradation of an iconic Arctic watershed with permafrost thaw
The streams of Alaska’s Brooks Range lie within a vast (~14M ha) tract of protected wilderness and have long supported both resident and anadromous fish. However, dozens of historically clear streams...
3D cryoimaging of cell-mediated cholesterol crystal clearance in human atherosclerotic lesions
We applied micro-computed tomography, high-resolution cryo-scanning electron microscopy (SEM) combined with cathodoluminescence, and cryo-focused ion beam Milling-SEM to perform three-dimensional imag...
Teeth outside the jaw: Evolution and development of the toothed head clasper in chimaeras
Chimaeras ( Holocephali ) are an understudied group of mostly deep-ocean cartilaginous fishes ( Chondrichthyes ) with un...