Proceedings of the National Academy of Sciences
Articles in this Issue
Biliverdin reductase A is a major determinant of protective NRF2 signaling
Biliverdin reductase A (BVRA), the terminal enzyme in heme catabolism, generates the neuroprotective and lipophilic antioxidant bilirubin. Here, we identify a nonenzymatic role for BVRA in redox regul...
How to upgrade stolen organelles into permanent plastids: A comparative transcriptomic perspective
Tertiary plastids derived from diatoms in “dinotom” dinoflagellates offer a rare view of organellogenesis in action, while the genomic and metabolic processes underlying their conversion remain poorly...
Living/controlled supramolecular protein polymerization
With the learning from living protein polymerization in nature, achieving living/controlled supramolecular assembly of biopolymers such as proteins in vitro is a longstanding challenge for material de...
The role of colony morphotype in shaping gene essentiality in <i>Mycobacteroides abscessus</i>
Changes in bacterial colony morphology are common during chronic human infections and are thought to provide a survival advantage. In the human pathogen Mycobacteroides abscessus...
Mitochondrial ROS triggers mitophagy through activating the DNA damage response signaling pathway
The homeostatic link between the production of mitochondrial ROS (mtROS) and mitophagy plays a significant role in how cells respond to various physiological and pathological conditions. However, it r...
Cranial modularity drives phenotypic diversification and adaptive radiation of Antarctic icefishes
Modularity among traits is thought to drive morphological evolution and diversification, with more modular species often showing greater morphological disparity and faster evolutionary rates. However,...
Wild canids and felids differ in their reliance on reused travel routeways
Diverse factors, including environmental features and cognitive processes, can drive animals’ movements and space use, with far-reaching implications. For example, repeated use of individual-level tra...
A mouse model of MEPAN demonstrates a role for mitochondrial fatty acid synthesis in iron–sulfur cluster and supercomplex formation
MEPAN ( M itochondrial E noyl CoA Reductase P rotein- A...
Higher-order interactions in neuronal function: From genes to ionic currents in biophysical models
Neuronal firing patterns are the consequence of precise variations in neuronal membrane potential, which are themselves shaped by multiple ionic currents. In this study, we use biophysical models, sta...
It’s cool to be green
Influence of the protein corona on hematopoietic stem and progenitor cell uptake and macrophage clearance of membrane-wrapped nanoparticles
The ideal delivery of therapeutic nanoparticles (NPs) to specific sites requires evading immune clearance and selectively binding target cells. Wrapping NPs in cell-derived membranes has shown promise...
Parallel reactions on a single T cell receptor offer a robust kinetic proofreading mechanism
T cells can recognize a few molecules of cognate antigen among vastly outnumbering noncognate ligands. The T cell receptor (TCR) differentiates antigens based on antigen–TCR binding dwell time through...
Genetic, phenotypic, and environmental drivers of local adaptation and climate change–induced maladaptation in a migratory songbird
Understanding processes driving local adaptation in wild species is a key goal in evolutionary biology, but linking genotype to phenotype to environmental drivers of natural selection remains challeng...
Long-term synchronous changes in body size among domesticated and wild species
The role of innate immunity, antibiotics, and bacteriophages in the course of bacterial infections and their treatment
Critical to our understanding of infections and their treatment is the role the innate immune system plays in controlling bacterial pathogens. Nevertheless, many in vivo systems are made or modified s...
Sustainable separation of rare earth elements from wastes
Rare earth elements (REEs) are indispensable in modern technologies, but their supply chain faces challenges due to limited geographical availability and political difficulties. Recycling REEs from in...
Molecular divergence and convergence of mammalian antibody responses to the influenza virus hemagglutinin stem
Antibody responses to the influenza virus hemagglutinin (HA) stem, a major target for broadly protective vaccine development, have been extensively characterized in humans. However, they remain largel...
High energy density carbon–cement supercapacitors for architectural energy storage
Electron-conducting carbon concrete (ecˆ3) is a multifunctional cement-based composite material that combines mechanical robustness with electrochemical energy storage. To further expand our understan...
Rust never sleeps: Climate change, permafrost thaw, and the rapid environmental degradation of wilderness river ecosystems
Meta-analysis finds large variation but no general patterns in the relationship between climate and parasitism in terrestrial animals
Climate can vary spatially and temporally and is becoming increasingly unpredictable due to climate change. It can have a large impact on host–parasite interactions and investigating this effect is vi...
RETRACTED: Curiouser and curiouser: Meningeal lymphoid structures in the aging brain
Mesoscale avalanche size underpins the rheology of granular yielding
Granular materials under loading exhibit intermittent avalanches of varying sizes prior to full yielding, a hallmark of natural failure phenomena such as landslides and earthquakes. While continuum mo...
Emerging hemispheric asymmetry of Earth’s radiation
Twenty-four years of satellite observations from the Clouds and the Earth’s Radiant Energy System show a northern hemisphere (NH) minus southern hemisphere (SH) trend difference of 0.34 ± 0.23 Wm...
Hidden order in active nematic defects
Hyperuniformity and giant number fluctuations represent opposite ends in a spectrum of statistical correlations found in physical systems outside of thermal equilibrium. Dynamic phase transitions exhi...
HISTONE DEACETYLASE-1 is required for epigenome stability in <i>Neurospora crassa</i>
Polycomb group (PcG) proteins form chromatin modifying complexes that stably repress lineage- or context-specific genes in animals, plants, and some fungi. Polycomb Repressive Complex 2 (PRC2) catalyz...