Proceedings of the National Academy of Sciences
Articles in this Issue
CAR-SPLASH identifies nascent pre-mRNA structures implicated in kinetic coupling and alternative splicing
Pre-mRNA splicing is kinetically coupled to transcription as shown by the widespread effects of transcription speed on alternative splicing (AS) outcomes. The molecular basis for such kinetic coupling...
The distinctive innovation patterns and network embeddedness of scientific prizewinners
Science prizes purportedly reward innovation and explorations of new phenomena. Yet in practice, prizes may inadvertently divert resources from similarly impactful but less celebrated scholars. Despit...
Tyrosine phosphorylation coupling of one-carbon metabolism and virulence in an endogenous pathogen
Endogenous pathogens can constrain virulence to ensure survival in the host. Pathogenic state can be controlled by metabolic responses to the prevailing microenvironment; however, the coupling and eff...
Hierarchical woven fibrillar structures in developing single gyroids in butterflies
Nature offers a remarkable diversity of nanomaterials that have extraordinary functional and structural properties. Intrinsic to nature is the impressive ability to form complex ordered nanomaterials...
Addressing the broader implications of AI–AI bias in decision-making systems
Reply to Bourguignon et al.: Convergence is a plausible hypothesis for Quina technology in East Asia
Reply to Yu et al.: Datasets, human judges, and future directions for evaluating AI–AI bias
The presence of Quina lithic technology in China 50 to 60 ka ago remains a hypothesis
Toward a relational biodiversity economics: Embedding plural values for sustainability transformation
The prioritization of market over nonmarket values of nature is a key driver of the global biodiversity crisis. Recognizing nature’s diverse values in decisions is a fundamental lever for sustainabili...