Proceedings of the National Academy of Sciences
Articles in this Issue
Identification of claudin-3 as an entry factor for rat hepacivirus
Approximately 58 million people worldwide are believed to be infected with hepatitis C virus (HCV), a major causative agent of chronic liver diseases. Hepacivirus ratti...
Molecular basis of SARS-CoV-2 proofreading enzyme–mediated resistance to remdesivir
SARS-CoV-2’s remarkable resistance to nucleotide analog antivirals such as remdesivir, which thwarts RNA synthesis by inhibiting viral polymerase (RdRp), challenges available therapies. We reveal that...
Current progress and research needs to protect children’s environmental health
Correction for Sakuma et al., Liver lipid droplet cholesterol content is a key determinant of metabolic dysfunction–associated steatohepatitis
Operation Warp Speed offers a roadmap for improving the efficiency of bench to bedside medical advances
Forest biodiversity increases productivity via complementarity from greater canopy structural complexity
The horizontal distribution and vertical stratification of tree crowns can affect light interception and tree growth, thus driving forest productivity and carbon storage. However, how canopy structure...
Correction for Li et al., Comprehensive tissue deconvolution of cell-free DNA by deep learning for disease diagnosis and monitoring
Functional diversity in GII.4 norovirus entry: HBGA binding and capsid clustering dynamics
Human noroviruses (HuNoVs), especially GII.4 strains, are the leading cause of acute viral gastroenteritis worldwide, yet no approved vaccines or antivirals exist. The pandemic GII.4 Sydney 2012 strai...
Aluminum speciation identification reveals water interactions in silicoaluminophosphate zeolites
Water plays a crucial role in material development. As it is ubiquitous throughout zeolite generation and application, host–guest interaction between zeolite and water attracts broad interest, but mec...
Correction for Hoffmann et al., Cancer cells suppress NK cell activity by actin-driven polarization of inhibitory ligands to the immunological synapse
Uncovering cargo clients and accessory factors of AP-1 and AP-4 through vesicle proteomics
The trans -Golgi network (TGN) is a crucial sorting station in the secretory pathway, where adaptor protein (AP) complexes ensure selective cargo packaging into...
Correction for Gilboa et al., Measurement of α-synuclein as protein cargo in plasma extracellular vesicles
Correction for Zhao et al., Blood–labyrinth barrier damage mediated by granzymes from cytotoxic lymphocytes results in hearing loss in systemic lupus erythematosus
Ultrasmall inorganic nanoparticles repair damaged meningeal lymphatic vessels to boost Parkinson’s disease therapy
Meningeal lymphatic vessels (MLVs) have been identified to associate with various neurological diseases, such as traumatic brain injury (TBI), Alzheimer’s disease (AD), Parkinson’s disease, multiple s...
Climate change intensifies plant–pollinator mismatch and increases secondary extinction risk for plants in northern latitudes
Climate change is altering the timing of species’ life-cycle events (i.e., phenology), but the rates of phenological shifts vary across taxa. These mismatches in phenological response may disrupt inte...
A fixed mutation in the respiratory complex I impairs mitochondrial bioenergetics in the endangered Apennine brown bear
Effective conservation genomics of endangered species requires realistic understanding of the fitness consequences caused by the accumulation of deleterious mutations in declining populations. We expe...
Engineering antibody–drug conjugates targeting an adhesion GPCR, CD97
Adhesion G protein–coupled receptors (aGPCRs) are key cell-adhesion molecules involved in many cellular functions and contribute to human diseases, including cancer. aGPCRs are characterized by large...
Hippocampal CA2 to CA1: A metaplastic switch for memory encoding
The hippocampus is essential for spatial and episodic memory, subserved by CA1 neurons. Hippocampal area CA2, which processes social memory, also makes direct connections to CA1. However, the function...
Mapping macaque to human cortex with natural scene responses
Neuroscience has long relied on macaque studies to infer human brain function, yet identifying functionally corresponding brain regions across species and measurement modalities remains a fundamental...
Protopeptide backbone affects assembly in aqueous solutions
One of the most fascinating mysteries in the field of origins of life concerns the driving force that led to the selection of today’s 20 universal L -alpha amin...
The impact of air pollution on petcare utilization
Air pollution is one of the leading causes of morbidity and premature mortality globally. A large literature documents the adverse impacts of ambient air pollution on human health. In contrast, there...
An extended network for regulation of heme homeostasis in cells
Iron-bound tetrapyrroles (hemes) are essential for the regulation of cellular functions and bioenergetics. The processes of heme biosynthesis, transport, and degradation are responsible for the supply...
Spectroscopic Supermassive Dark Star candidates
Dark Stars (DSs), i.e., early stars composed almost entirely of hydrogen and helium but powered by Dark Matter (DM), could form in zero metallicity clouds located close to the center of high redshift...
Activation of epigenetic reprogramming via crotonylation overcomes resistance to EGFR-TKI therapy in lung cancer
Posttranslational modifications (PTMs) on histones play critical roles in cellular processes, including gene expression and tumorigenesis. However, the regulatory mechanisms and functional consequence...
Exceptionally broad HIV-1 neutralization via bispecific antibody–mediated prepositioning
Antibodies that recognize the conserved prehairpin intermediate (PHI) of class I viral membrane-fusion proteins typically show limited neutralization and have not been considered promising therapeutic...