Proceedings of the National Academy of Sciences
Articles in this Issue
Abscisic acid regulates iron accumulation in plant seeds via the PYLs–bHLH IVc–YSLs module
Abscisic acid (ABA) is pivotal in seed development, yet its role in iron (Fe) homeostasis remains unclear. Here, we reveal a PYLs–bHLH IVc–YSLs module that mediates ABA-dependent suppression of seed F...
Divergent evolutionary dynamics of benign and malignant tumors
Benign and malignant (cancerous) tumors differ markedly in their impact on organismal fitness, yet studies in comparative oncology rarely distinguish between them. Using a Bayesian phylogenetic framew...
The role of active mRNA–ribosome dynamics and closing constriction in daughter chromosome separation in <i>Escherichia coli</i>
The mechanisms by which two sister chromosomes separate and partition into daughter cells in bacteria remain poorly understood. A recent theoretical model has proposed that out-of-equilibrium central...
BRAF inhibition increases TGFβ2 production and stimulates metastasis in mice with endogenous BRAF <sup>V600E</sup> -induced hepatocellular carcinoma
The MEK–ERK pathway is a key driver of hepatocellular carcinoma (HCC) pathogenesis, and BRAF mutations, particularly BRAF V600E , can contribute to its activati...
Amino acid insufficiency impairs hepatic vitamin A mobilization in mice
Retinol-binding protein 4 (RBP4) is the sole specific serum carrier of vitamin A, delivering it from the hepatic stores to the peripheral organs in a complex with retinol (ROH) and transthyretin (TTR)...
Direct and in situ examination of Li <sup>+</sup> transport kinetics in an isotope-labeled solid–electrolyte interphase
Solid–electrolyte interphase (SEI) is the critical component in all advanced battery chemistries, whose ionic transport and electron leakage behaviors remain least understood among all battery compone...
A viral Cyclin D homolog protein hijacks the metabolic stress sensor SESN2 to promote primary effusion lymphoma growth
Metabolic pathways are typically dysregulated in cancer to support critical cellular processes. In response to metabolic disturbances, cancer cells preferentially manipulate stress sensors to enhance...
Structural basis for a potent human neutralizing antibody targeting a conserved epitope on the H7 hemagglutinin head
Zoonotic H7N9 avian influenza virus infection remains a global concern because of its pandemic potential. Therefore, developing effective antibodies and vaccines against H7N9 is vital for preventing a...
Hund’s flat band in a frustrated spinel oxide
Electronic flat bands associated with quenched kinetic energy and heavy electron mass have attracted great interest for promoting strong electronic correlations and emergent phenomena such as high-tem...
Secreting salt glands constrain cuticle fracture to enhance desalination efficiency
Plants responding to excessive soil salinity by discharging brine onto their leaf surface risk dehydration through the osmotic continuity between the living tissue and the surface brine, which further...
Correction for Young-Brun et al., Within-country inequality and the shaping of a just global climate policy
Correction for Zhou et al., 9,000-year-old barley consumption in the foothills of central Asia
Correction for Lu and Kang, Efficient acquisition of dual metastasis organotropism to bone and lung through stable spontaneous fusion between MDA-MB-231 variants
Correction for Bellis et al., Genomics of sorghum local adaptation to a parasitic plant
Revisiting the high-dimensional geometry of population responses in the visual cortex
Recent advances in large-scale recording technology have spurred inquiries into the high-dimensional geometry of the neural code. However, characterizing this geometry from noisy neural responses, par...
The geometry of jamming algorithms in the random Lorentz gas
Deterministic optimization algorithms unequivocally partition a complex energy landscape into inherent structures (ISs) and their respective basins of attraction. Can these basins be defined solely th...