Proceedings of the National Academy of Sciences
Articles in this Issue
DDHD2 possesses both lipase and transacylase capacities that remodel triglyceride acyl chains
Hereditary spastic paraplegia subtype SPG54 is a genetic neurological disorder caused by mutations in the DDHD2 gene. Excessive lipid droplet accumulation is observed in the brains of SPG54 patients a...
An AINTEGUMENTA phosphoswitch controls bilateral stem cell activity during secondary growth
Plant stem cells have the remarkable ability to give rise to distinct tissues and organs throughout development. Two concentric cylinders of actively dividing stem cells are the main drivers of radial...
Structural basis of modified ligand selectivity from N-terminal PAC1R alternative splicing
The pituitary adenylate cyclase-activating polypeptide (PACAP) 1 receptor (PAC1R) is a class B1 G protein–coupled receptor activated by the endogenous peptide agonists PACAP and vasoactive intestinal...
ATP-dependent actin barbed-end fluctuations at steady state
Actin networks in cells are dynamic and constantly turning over as actin subunits exchange between monomer and polymer pools. Understanding these dynamics in vivo requires a detailed understanding of...
Students’ motives for restricting academic freedom: Viewpoint discrimination and prosocial concerns
We advance the understanding of so-called “cancel culture” at the university by presenting the results of three survey experiments among university students. Designed in an “adversarial collaboration”...
Defects at play: Shaping the photophysics and photochemistry of ice
The mechanisms by which light interacts with ice and the impact of photoinduced reactions are central to our understanding of environmental, atmospheric, and astrophysical processes. However, a micros...
Biodiversity conservation requires consideration of different life history stages
Amid the biodiversity crisis, functional diversity, which is critical for ecosystem stability and conservation planning—faces challenges due to species’ complex life cycles. As the majority of animals...
Creatine kinase imaging (CKI) for in vivo whole-brain mapping of creatine kinase reaction kinetics
The creatine kinase (CK) is a key enzyme involved in brain bioenergetics, playing an important role in brain function and the pathogenesis of neurological and psychiatric diseases and cancers. However...
A chromatin-linked CPL2–PHD2/3 module sustains multiple DNA methylation pathways and Polycomb silencing
While multiple chromatin-based epigenetic pathways are well characterized, their genome-wide coordination and hierarchical interplay remain poorly understood. We previously identified the BAH–PHD–CPL2...
Joubert syndrome 26 protein enforces compartmentalized motility of a ciliary kinesin
Cilia are essential cellular antennae that rely on precise motor-driven transport to assemble and function. Two kinesin-2 motors—kinesin-II and OSM-3 in Caenorhabditis elegans...
Object continuity through invisible retinal motion at saccadic speed
Saccadic eye movements rapidly shift the visual scene across the retina, raising the question of how object correspondence is established between gaze fixations. Using submillisecond video projection,...
Merging different allosteric mechanisms: The case of <i>Escherichia coli</i> glutathione reductase
Cooperative regulation of biomolecular function is critical for the ability of all organisms to respond effectively to environmental changes. Such regulation is often manifested in a sigmoidal depende...
Loss of conductance between mesophyll symplasm and intercellular air spaces explains nonstomatal control of transpiration
The conventional assumption is that stomatal conductance ( g s...
Glutathionylated DNA adducts accumulate in mitochondrial DNA and are regulated by AP endonuclease 1 and tyrosyl-DNA phosphodiesterase 1
Mitochondrial DNA (mtDNA) is crucial for cellular energy production, metabolism, and signaling. Its dysfunction is implicated in various diseases, including mitochondrial disorders, neurodegeneration,...
MAPK signaling and angiopoietin-2 contribute to endothelial permeability in capillary malformations
Nonsyndromic capillary malformations (CM) are seen predominantly in skin. In Sturge–Weber Syndrome (SWS), CMs occur in the skin, leptomeninges of the brain, and choroid of the eye. >90% of CM are c...
QnAs with Graham F. Hatfull
Correction for Zhang et al., TaHSP18.6 and TaSRT1 interact to confer resistance to <i>Fusarium</i> crown rot by regulating the auxin content in common wheat
A tripartite protein complex promotes DNA transport during natural transformation in Firmicutes
Natural genetic transformation is a conserved mechanism of bacterial horizontal gene transfer, which is directed entirely by the recipient cell and facilitates the acquisition of new genetic traits su...
A periplasmic zinc capture protein enhances the resistance of <i>Neisseria gonorrhoeae</i> to nutritional immunity
During microbial infection, mammalian hosts reduce the availability of free metals such as zinc in a process known as nutritional immunity. Pathogens counteract nutritional immunity by expressing gene...
Heating rate gradient drives mesostructural dynamics in solid propellant under nonequilibrium conditions
Rapid, nonequilibrium heating drives mesoscale structural evolution in heterogeneous composite materials under extreme thermal conditions, critically influencing performance in aerospace propulsion an...
Glyceraldehyde-3-phosphate dehydrogenase homologs as bifunctional gatekeepers of metabolic segregation in <i> <i>Pseudomonas</i> putida </i>
Metabolically versatile Pseudomonas species can assimilate various glycolytic and gluconeogenic substrates. Simultan...
Coordinated transfer of DNA between Pol θ and Pol δ resets microhomology choice during double-strand break repair
DNA polymerase theta (Pol θ)-mediated end joining (TMEJ) initiates DNA double-strand break repair by using short homologies (microhomologies) between single-stranded DNA tails. This repair process is...
Substantial planar plastic anisotropy in inorganic Mg <sub>3</sub> Bi <sub>2</sub> single crystals
Elucidating the fundamental microscopic mechanisms governing plastic deformation is crucial for the rational design of functional materials with tailored mechanical properties. Recent advances in Mg...
Correction for Goyette et al., Cancer–stromal cell interactions in breast cancer brain metastases induce glycocalyx-mediated resistance to HER2-targeting therapies
The configurational length scale in the self-assembly and modulation of higher-order transient protein structures
Membrane protein homo-oligomers named higher-order transient structures (HOTS) are formed through cohesive self-interactions in the range of a few...