Proceedings of the National Academy of Sciences
Articles in this Issue
Localized nutrient colimitation of phytoplankton growth rates across the subtropical South Pacific Ocean
The simultaneous depletion of multiple nutrients in seawater potentially leads to colimitation of phytoplankton growth across large oceanic extents. Single limitation versus colimitation carries impli...
High-resolution lidar observations of sedimentation-induced size sorting of droplets near a laboratory cloud top
Cloud optical properties and precipitation, which are crucial to weather and climate, are strongly influenced by cloud microphysical properties that are still poorly understood. Here, we develop a hig...
A metabolic cell death program downstream of SARM1 couples NAD <sup>+</sup> depletion to BAX activation and APAF1 degradation
SARM1 is a neuronal Nicotinamide adenine dinucleotide (NAD + ) hydrolase that drives axonal degeneration and neuronal death by depleting NAD...
Globally aggregated biodiversity data impact predictive and descriptive research
Here, we present an analysis of the growth and use of the Global Biodiversity Information Facility (GBIF) over the last 5 y. GBIF is the world’s largest data integrator for biodiversity information an...
Droplet-on-demand mass spectrometry reveals curvature-dependent interfacial reactivity in aqueous microdroplets
Water microdroplets offer a chemical environment that can dramatically accelerate reaction rates compared to bulk-phase solutions and even drive chemical transformations not found in bulk solutions. W...
Climate sensitivity is widely but unevenly spread across zoonotic diseases
Climate change is expected to exacerbate infectious diseases, yet the climate sensitivity of zoonotic diseases (driven by spillover from animal reservoirs) is understudied compared to vector-borne and...
Three distinct components of pragmatic language use: Social conventions, intonation, and world knowledge–based causal reasoning
Successful communication requires frequent inferences. Such inferences span a multitude of phenomena: from understanding metaphors, to detecting irony and getting jokes, to interpreting intonation pat...
Organization principles of dynamic three-dimensional genome architecture associated with centromere clustering states
Fungal centromeres are clustered near microtubule organizing centers to help adopt the Rabl chromosomal organization. The role of centromere clustering in driving large-scale changes in structural and...
Molecular mechanisms underlying p62-dependent secretion of the Alzheimer-associated ubiquitin variant UBB <sup>+1</sup>
UBB +1 , a ubiquitin variant protein resulting from a frameshift in the ubiquitin-B gene, is a pathological hallmark of Alzheimer disease (AD). At the cellular...
Resolved tropical cyclones trigger CO <sub>2</sub> uptake and phytoplankton bloom in an Earth system model simulation
The ocean carbon cycle is directly impacted by storms in the atmosphere. Tropical cyclones (TCs), particularly, are known to drive intense air–sea CO 2 fluxes a...
Generative epigenetic landscapes map the topology and topography of cell fates
Epigenetic landscapes were proposed by Waddington as the central concept to describe cell fate dynamics in a locally low-dimensional space. In modern landscape models, attractors represent cell types,...
Intracellular <i>Acinetobacter baumannii</i> acts as a transient reservoir in lung infection via a “persist and resist” strategy
Although considered primarily extracellular, Acinetobacter baumannii can survive and replicate within macrophages in vitro. Intracellular bacteria are often pro...
IL-27 promotes Treg cell expression of CD122 and fitness at homeostasis
Regulatory T (Treg) cells express high levels of the IL-27R, and in the setting of infection and autoimmunity, the cytokine IL-27 promotes Treg cell activities that mitigate tissue pathology. However,...
Enhanced dispersion of active microswimmers in confined flows
In the presence of a laminar shear flow, the diffusion of passive colloidal particles is enhanced in the direction parallel to the flow. This classical phenomenon is known as Taylor–Aris dispersion. B...
WDFY4-dependent cross-presentation proceeds via a vacuolar antigen-processing route
The intracellular processing route used by type I conventional dendritic cells (cDC1) for cross-presentation of viral- or tumor-associated antigens remains controversial. One model proposes that captu...
<i> <i>Vibrio cholerae</i> </i> biofilm matrix assembly and growth are shaped by a glutamate-specific TAXI/TRAP protein
Biofilms are critical for the environmental persistence, survival, and infectivity of Vibrio cholerae , the causativ...
HLA-DQB1*03:01 strongly affects age of onset of type 1 narcolepsy independently of DQA1 and ethnicity
Type 1 narcolepsy (T1N), an autoimmune disease associated with a disruption of hypocretin/orexin neurons, has conserved genetic effects transcending cultures and ethnicities. We pooled data from 5,339...
Heterogeneous template-dependent transcription dynamics of T7 RNAP revealed by single-molecule imaging
Bacteriophage T7 RNA polymerase (T7 RNAP) is commonly used for large-scale RNA synthesis in science and industry. Although T7 RNAP exhibits high processivity, its usage faces two major challenges: Dur...
Structural basis and evolutionary pathways of glycerol-1-phosphate transport in marine bacteria
All cells use lipid membranes to maintain cellular integrity and function, though Archaea utilize lipids composed of glycerol-1-phosphate (G1P), while Bacteria and Eukaryotes use glycerol-3-phosphate...
An electron transport complex required in the gut sensitizes <i>Bacteroides</i> to a pore-forming type VI secretion toxin
Data suggest that antagonism between bacteria is prevalent within the gut microbiome. Such antagonism could have profound consequences on the fitness of species; however, the susceptibility determinan...
Upper mantle temperatures illuminate the Iceland hotspot track and understanding of ice–Earth interactions in Greenland
The thermal structure of the Earth beneath Greenland reflects the tectonic history of the region and impacts ice sheet evolution due to surface heat flow and the influence of temperature on Earth rheo...
Demographic responses of North Atlantic seabirds to seasonal ocean warming
Climate-driven ocean warming is profoundly reshaping marine ecosystems, with cascading effects on biodiversity and trophic interactions. For migratory marine predators such as seabirds, demographic re...
Actin network heterogeneity tunes activator–inhibitor dynamics at the cell cortex
Biological systems can display diverse patterns of self-organization, even when built on conserved networks of interaction between molecular species. In these cases, reaction–diffusion equations provi...
Amazon forest faces severe decline under the dual pressures of anthropogenic climate change and land-use change
The Amazon is a key climate system component, hotspot of biodiversity and many other ecosystem functions. However, progressive rainforest degradation, driven by anthropogenic climate change and land-u...
Mapping epileptogenic brain using a unified spatial–temporal–spectral source imaging framework
Noninvasive electrophysiological source imaging (ESI) is a valuable tool for localizing and imaging brain activity, with significant potential to aid presurgical planning in focal drug-resistant epile...