Blood
Articles in this Issue
Regional disparities and socioeconomic determinants of pediatric lymphoid leukemia mortality in Brazil from 2000-2021
Abstract Introduction: Leukemias are the most frequent cancers in childhood and adolescence, and socioeconomic factors are known to be relat...
Factor v inhibits factor x activation by the tissue factor-factor VIIa complex
Abstract Background: Factor V (FV) has pro- and anticoagulant roles in the regulation of coagulation. This is reflected in the paradoxical o...
Outcomes after relapse for adolescent and young adult patients with ALL: Results from the Children's oncology group
Abstract Background Outcomes for adolescents and young adults (AYAs) with acute lymphoblastic leukemia (ALL) are improvi...
Integrated genomic and tumor microenvironment subtyping refines risk stratification in primary central nervous system lymphoma
Abstract Purpose: Primary CNS lymphoma (PCNSL) remains a therapeutic challenge due to limited precision medicine approaches and suboptimal r...
The influence of age on patient-reported outcomes (PROs) endpoints on the S1826 cross-network Phase III trial of advanced-stage, classic Hodgkin lymphoma (cHL)
Abstract Introduction Patients (pts) with newly diagnosed, advanced-stage cHL are at risk for poor health-related quality of life (HRQoL) du...
Myeloablative fractionated busulfan, fludarabine, cladribine, thiotepa, and venetoclax (Cladillac) conditioning for high-risk AML: A phase 2 trial
Abstract Background: Patients with high-risk acute myeloid leukemia (AML) continue to experience poor outcomes despite undergoing stem cell...
Donor-derived secondary CAR-T cell therapy for relapsed leukemia following initial CAR-T bridged to allogeneic transplantation: Efficacy and safety analysis
Abstract Background Relapse following CAR-T therapy bridged to allogeneic hematopoietic stem cell transplantation (allo-HSCT) represents a t...
Myeloid sarcoma: A population based retrospective study
Abstract Introduction Myeloid sarcoma (MS) is an extramedullary form of acute myeloid leukemia (AML). It is a high grade hematologic maligna...
More than a decade without treatment: Time to first treatment in CLL in a chilean cohort
Abstract Background: Chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease, with time to first treatment (TTFT) being a c...
Comparative 3- and 5-year outcomes among first-line imatinib, dasatinib, and nilotinib in chronic myeloid leukemia: A real world analysis
Abstract Background: First-line tyrosine kinase inhibitor (TKI) selection in chronic myeloid leukemia (CML) impacts both molecular response...
Seasonal variation in chronic and acute pain in patients with sickle cell disease
Abstract Introduction: Pain events are the most common symptom of sickle cell disease (SCD) and many patients with SCD also develop chronic...
A reduced-frequency targeted combination regimen ( DVd-lite) for the treatment of newly diagnosed multiple myeloma with renal impairment: A single-center, open-label, prospective clinical study
Abstract Objective: This study aimed to evaluate the efficacy and safety of the reduced-frequency targeted combination regimen DVd-lite (dar...
Impact of race on the incidence, diagnosis and outcomes of pregnancy-associated venous thromboembolism: A nested case-control study
Abstract Background: Venous thromboembolism (VTE) is a potentially life-threatening complication of pregnancy. While diagnostic delays are a...
Racial disparities in genomic alterations and survival outcomes in Acute Myeloid Leukemia (AML)
Abstract Background: Survival outcomes in AML are influenced by multiple patient- and disease-related factors, including age, performance st...
Apply-PNH: Analysis of complement pathway biomarkers provides evidence for pharmacodynamic response in PNH patients who receive oral iptacopan monotherapy versus continuing anti-C5 therapy
Abstract Introduction: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired hemolytic disorder characterized by complement-mediated...
Outcomes of pediatric patients transplanted for B-ALL with high-risk cytogenetics- a 20-year experience from LMIC setting
Abstract Introduction Cytogenetics are increasingly utilized in guiding risk stratification and treatment in pediatric A...
Functional characterization of Sec14L4 in hudep-2 and mouse knockout models reveals its essential role in erythropoiesis.
Abstract Background Red blood cell (RBC) transfusion is a common intervention for hospitalized patients, particularly those with sickle cell...
Plasma proteomic profiles predict future non-Hodgkin lymphoma in healthy adults
Abstract Background: Non-Hodgkin lymphoma (NHL) is the most common type of lymphoma, with diffuse large B-cell lymphoma (DLBCL) and follicul...
Trends in second primary malignancies in myelofibrosis pre- and post-JAK inhibitor era: A surveillance, epidemiology and end-Results database study
Abstract Background Ruxolitinib, the first JAK inhibitor approved for the treatment of myelofibrosis in 2012, was...
Multicenter real-world outcomes in limited stage (LS) diffuse large B-cell lymphoma (DLBCL) treated with abbreviated immunochemotherapy
Abstract Background: For LS-DLBCL, clinical trials (FLYER, LYSA/GOELAMS 02-03, LYSA LNH09-1B, S1001) have shown that 4 cycles of rituximab,...
The immunomodulatory effects of IRF3/7 transcription factors and IL10 in ALK+ anaplastic large cell lymphoma (ALCL)
Abstract Introduction: Anaplastic lymphoma kinase-positive anaplastic large cell lymphoma (ALK+ ALCL) is a distinct aggressive T-cell non-Ho...
Endothelial cell-derived mitochondrial transfer to Acute Myeloid Leukemia alters global gene expression to confer chemoresistance
Abstract Acute myeloid leukemia (AML) exhibits high relapse rates, suggesting the existence of robust mechanisms that protect leukemic cells...
Camelot-2: A phase 3 randomized, double-blind, placebo-controlled, study of bleximenib, venetoclax and azacitidine for the treatment of participants with newly diagnosed Acute Myeloid Leukemia harboring KMT2A rearrangements or NPM1 mutations, who are ineligible for intensive chemotherapy
Abstract Background and Significance Newly diagnosed (ND) acute myeloid leukemia (AML) with KMT2A rearrangement (KMT2Ar)is associated with po...
Combined factor v and VIII deficiency: A mucocutaneous bleeding phenotype driven predominantly by factor VIII – a retrospective study of 34 patients
Abstract BACKGROUND Combine factor V and VIII deficiency (F5F8D) is a rare autosomal recessive bleeding disorder (<1/million) caused b...
RIT1 mutations in myeloid neoplasms
Abstract Background: Constitutive activation of the RAS/MAPK cascade due to mutations in canonical RAS-family proteins, upstream tyrosine ki...