Blood
Articles in this Issue
From focal lesion to fat sparing: Unmasking Zieve's syndrome with clinical vigilance
Abstract Zieve's syndrome is a rare and often overlooked complication of alcohol misuse, likely under-recognized due to limited physician aw...
Provider practices and preparedness for gene therapy in pediatric sickle cell disease: A national survey of pediatric hematologists
Abstract Introduction: Sickle cell disease (SCD) is a severe, life-limiting genetic disorder affecting over 100,000 individuals in the U.S....
Access barriers and treatment patterns in Philadelphia-negative myeloproliferative neoplasms (Ph- MPN): Insights from a brazilian physician survey
Abstract Introduction: Effective management of Philadelphia-negative myeloproliferative neoplasms (Ph- MPNs)—including polycythemia vera (PV...
Trials in progress - A phase I study of loncastuximab tesirine and rituximab following stereotactic radiosurgery in patients with primary and secondary central nervous system lymphomas (SOLAR)
Abstract Background: Central nervous system lymphomas (CNSL) carry a poor prognosis and remain difficult to treat due to limited effective t...
Safety analysis of axatilimab in patients with chronic graft-versus-host disease in an expanded access program
Abstract Introduction: Chronic graft-versus-host disease (cGVHD) is an immune-mediated complication of allogeneic hematopoietic stem cell tr...
Rituximab, lenalidomide, and zanubrutinib (ZR2) with sequential CAR-T cell as first-line therapy for high-risk large B cell lymphoma
Abstract Background High-risk large B-cell lymphoma (LBCL) demonstrates poor response rates and prognosis with standard chemotherapy, which...
Consolidation of dual MAPK inhibitor therapy by allograft in histiocytic sarcoma: A report of two cases
Abstract Introduction: Histiocytic sarcoma (HS) is a high-risk histiocytic neoplasm often involving mutations in mitogen-activated protein k...
Outcomes of allogeneic hematopoietic stem cell transplantations (HSCT) for treatment of secondary primary malignancies arising post-autologous HSCT for multiple myeloma
Abstract Secondary primary malignancies (SPMs) are a known complication of multiple myeloma (MM) and its treatment; resulting from baseline...
RUNX1 mutations and outcomes in Acute Myeloid Leukemia: A public data-based analysis framing racial disparities in genomic risk
Abstract Background: RUNX1 mutations are established high-risk features in acute myeloid leukemia (AML), associated with poor response to in...
Evaluating the CAR-hematotox score in patients with refractory-relapsed multiple myeloma treated with bispecific T-cell engager therapy
Abstract Background: The CAR-HEMATOTOX score (HTx) is a validated tool for predicting the risk of severe cytopenias following CAR-T cell the...
Spatially resolved profiling reveals the perifollicular border zone as a key immunologic hub in follicular lymphoma undergoing mosunetuzumab therapy
Abstract Introduction. The tumor microenvironment (TME) plays a central role in the efficacy of T cell-engaging immunotherapies, including C...
Robust HbF induction and improvement of anemia and hemolysis with base editing in sickle cell disease: Safety and efficacy findings from the ongoing BEACON study
Abstract Introduction Elevated levels of fetal hemoglobin (HbF) ameliorate sickle cell disease (SCD) manifestations. BEAM-101 is an investig...
Metabolic reprogramming of megakaryocyte subpopulations in ITP: Implications for TSPO in predicting response to TPO-RA
Abstract Background Single-cell sequencing has revolutionized our understanding of the versatile nature of megakaryocyte subpopulations, amo...
Long term follow up autologous CD30.CAR-T cells in combination with nivolumab in patients with relapsed or refractory classical Hodgkin lymphoma after failure of frontline therapy
Abstract Sairah Ahmed1*, Matthew Mei2* *co-first authors Introduction Classical...
Novel epitranscriptomic biomarker discovery through ensemble analysis and multi-omics integration in AML
Abstract Acute Myeloid Leukemia (AML) is a biologically heterogeneous and clinically aggressive malignancy characterized by poor survival an...
Diagnostic challenges in adult hemophagocytic lymphohistiocytosis: A case series
Abstract Introduction: Hemophagocytic lymphohistiocytosis (HLH) is a severe inflammatory condition marked by non-specific symptoms like feve...
Interferon alfa treatment of early primary myelofibrosis is associated with improved overall survival
Abstract Background: The optimal treatment of early primary myelofibrosis (PMF) – prefibrotic PMF (prePMF) or low/intermediate-1 (int-1) ris...
Social support and barriers to medication adherence among adolescents and young adults with leukemia and lymphoma
Abstract Background: Medication nonadherence is demonstrated by up to 60% of adolescents and young adults (AYAs) with leukemia and lymphoma...
Upfront therapy with allogeneic hematopoietic stem cell transplantation versus DNA methyltransferase inhibitors in patients with vexas syndrome: A comparative matched cohort efficacy analysis of 39 patients
Abstract Background: VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) syndrome is a hemato-inflammatory syndrome due to soma...
First-in-class immunomodulatory anti-heat shock protein 70 (HSP70) antibody demonstrates broad antitumor activity across myeloma, lymphoma, and solid tumor models
Abstract Background: Treatment resistance and relapse in myeloma and lymphoma are driven by diverse immunosuppressive mechanisms within the...
Comparing the outcomes of autologous versus allogeneic stem cell transplant as consolidative and relapsed/refractory treatment in peripheral T-cell lymphomas
Abstract Introduction: The role of hematopoietic stem cell transplant remains undefined in the treatment of many peripheral T-cell lymphoma...
Characterization of gut microbiota and metabolomics in patients with Acute Myeloid Leukemia for journal publication requirements
Abstract ObjectiveThis study utilizes 16S rDNA gene sequencing technology and LC-MS/MS technology to examine the gut microbiota composition...
Phase 1 study of MK-1045, a novel CD19xCD3 T-cell engager, in participants with relapsed or refractory diffuse large B-cell lymphoma
Abstract Introduction: A variety of treatments options are available for relapsed or refractory (R/R) diffuse large B-cell lymphoma (DLBCL) a...
Alternate dosing schedules of BCMA-directed T cell engagers display altered pathways of relapse in syngeneic vk*MYC multiple myeloma
Abstract Background: B-cell maturation antigen (BCMA)-targeted T cell engagers (TCEs) have emerged as a highly potent immunotherapy for rela...
Evaluation and validation of automated multiplexed immunofluorescence for clinical lymphoma diagnoses
Abstract B-cell lymphomas encompass a wide range of malignancies, with clinical features ranging from indolent to aggressive. The diagnosis...