Blood
Articles in this Issue
The efficacy and safety of switching to olverembatinib or continuing original TKI therapy in CML-CP patients treated with at least two prior TKIs: A prospective, multicenter, controll trial
Abstract Introduction: Olverembatinib (HQP1351) is a novel third-generation BCR-ABL1 tyrosine kinase inhibitor (TKI) in chronic myeloid leuke...
Efficacy of cyclosporine and antithymocyte or antilymphocyte globulin in the management of aplastic anemia: A systematic review and meta-analysis
Abstract Introduction: The efficacy of combined cyclosporine (CsA) and antithymocyte/antilymphocyte globulin (ATG/ALG) therapy for aplastic...
Therapeutic potential of mitochondrial transplantation in the treatment of MDS
Abstract Currently the only curative treatment option for patients with myelodysplastic syndromes (MDS) is allogeneic bone marrow transplant...
Germline mediated HR deficiency, alu element duplication, and immune pathway alterations define aggressive, drug-resistant multiple myeloma
Abstract Background: Multiple Myeloma (MM) is a plasma cell malignancy characterized by genomic instability, often manifesting as chromothri...
Ziftomenib in combination with venetoclax and azacitidine in relapsed/refractory NPM1-m or KMT2A-r acute myeloid leukemia: Updated phase 1a/b safety and clinical activity results from KOMET-007
Abstract Introduction: Leukemogenesis is driven by nucleophosmin 1 mutations(NPM1-m) or lysine methyltransferase 2A rearrangements(KMT2A-r)...
Quality initiative in first-line multiple myeloma assessing the use of anti-CD38 agents and quadruplet therapy
Abstract Background: The University of Pittsburgh Medical Center (UPMC) partnered with IntegraConnect to conduct a quality initiative (QI) s...
Barriers to optimal care and educational opportunities for european physicians treating patients with relapsed/refractory (R/R) CLL
Abstract Background: Healthcare professionals (HCPs) who manage patients with CLL are challenged to provide optimal care as treatment paradi...
Digital diagnosis: the development of electronic laboratory simulations to promote active learning in hematology among first-year medical students
Abstract BACKGROUND Hematology inundates learners with facts and details. Teaching students to identify patterns and render diagnoses poses s...
Addressing institutional barriers in sickle cell pain management: A resident-led quality improvement study
Abstract INTRODUCTION Sickle Cell Disease (SCD) affects over 100,000 individuals in the U.S., with vaso-occlusive crises (VOC) being the lead...
Active cancer as a risk factor for inappropriate VTE prophylaxis: Data from a single center study
Abstract Introduction: Hospitalized patients with cancer represent a high-risk group for venous thromboembolism (VTE) due to a hypercoagulab...
Outcomes of autologous transplant (ASCT) in patients with chemosensitive late relapse of large B-cell lymphoma (LBCL)
Abstract Introduction CAR T cell treatment is the standard of care for patients (pts) with primary refractory and relaps...
Secondary Acute Myeloid Leukemia transformed from chronic myelomonocytic leukemia is strongly resistant to venetoclax but demonstrates sensitivity to anti-GM-CSF lenzilumab immunotherapy
Abstract Introduction:Secondary acute myeloid leukemia arising from prior myelodysplastic syndrome or chronic myelomonocytic leukemia accoun...
Selecting the optimal bridging therapy for B-ALL: A multicenter comparison of blinatumomab, inotuzumab ozogamicin, and CAR-T prior to allo-HSCT
Abstract Background: The incorporation of novel immunotherapeutic and cellular approaches—including blinatumomab, inotuzumab ozogamicin, and...
Belumosudil for chronic graft-versus-host disease in children under 12: A retrospective analysis of effectiveness and safety
Abstract Background: Chronic graft-versus-host disease (cGVHD) is a major cause of morbidity and mortality following allogeneic hematopoieti...
EZH2 gain-of-function events distinctly impact germinal center B cells depending on timing in the B lineage
Abstract The two most common types of Non-Hodgkin Lymphoma (NHL) are Diffuse Large B Cell Lymphoma (DLBCL) and Follicular Lymphoma (FL). Up...
Spatial profiling of the bone marrow microenvironment in patients with IgM gammopathies reveals a T cell–Enriched tumor niche associated with asymptomatic waldenstrom macroglobulinemia progression
Abstract INTRODUCTION While the genetic drivers of Waldenström macroglobulinemia (WM) are well characterized, the contribution of the bone ma...
Feasibility, reliability, and accuracy of point-of-care measurements of fetal hemoglobin
Abstract Background: Fetal hemoglobin (HbF) is a key determinant of disease severity and an important therapeutic biomarker in sickle cell d...
Management and outcomes of patients diagnosed with chronic myeloid leukemia in blast Phase: A multicenter analysis by the h jean khoury cure CML consortium
Abstract Introduction: Despite advent of multiple tyrosine kinase inhibitors (TKIs) and newer treatment methods for AML...
Efficacy and safety of melphalan/TBI-based conditioning regimens (MCAC/TCAC) for autologous HSCT in adult acute lymphoblastic leukemia: A multicenter, prospective cohort study
Abstract Introduction Autologous hematopoietic stem cell transplantation (auto-HSCT) is a primary consolidation option f...
Patterns of palliative care utilization across health sectors in patients with aggressive non-Hodgkin lymphoma.
Abstract Introduction: Patients with aggressive non-Hodgkin lymphoma (NHL) experience high physical and psychological burden related to thei...
Bridging the rural gap: Real-world teclistamab outcomes from the u.S. midwest myeloma network
Abstract Background: Teclistamab, a BCMA×CD3 bispecific T-cell engager, offers an off-the-shelf immunotherapy option for relapsed/refractory...
FLT3 testing and guideline concordance in Acute Myeloid Leukemia across an Indiana health system
Abstract Background: FLT3 mutations occur in approximately 30% of patients with acute myeloid leukemia (AML) and are ass...
Sinusoidal endothelial cell-derived FGF23 modulates hematopoiesis in mice
Abstract Fibroblast growth factor 23 (FGF23), a phosphaturic hormone produced by osteocytes, has been found to negatively regulate erythropo...
Therapeutic effects of Tmprss6 suppression are negated by iron overload in a mouse model of beta-thalassemia
Abstract Beta-thalassemia, caused by genetic deficiency of beta-globin, is characterized by ineffective erythropoiesis and anemia. In additi...
Symptom burden in patients with cancer and thromboembolism: A population-based matched cohort study
Abstract Background: Arterial (ATE) and venous thromboembolism (VTE) are common complications of cancer, but their impact on cancer symptom...