Blood
Articles in this Issue
Interim report of a phase 1/2 study of ESG206 in patients with refractory or relapsed primary immune thrombocytopenia
Abstract Introduction: Blockade of the BAFF-R signaling pathway and depletion of BAFF-R–expressing B cells may offer clinical benefit to pat...
Fertility preservation in AYA oncology: Provider knowledge gaps, counseling practices, and barriers to care
Abstract Background: In the United States, nearly 90,000 adolescents and young adults (AYAs) aged 15–39 are diagnosed with cancer annually....
Eltrombopag promotes hematopoietic engraftment and improves the survival of bone marrow failure disease following hematopoietic stem cell transplantation
Abstract Background Bone marrow failure disease (BMFD) arises from congenital or acquired hematopoietic stem cell dysfunction, characterized...
Rituximab plus lenalidomide (R²) versus standard therapies in follicular lymphoma: A systematic review and meta-analysis of randomized controlled trials
Abstract Introduction: Follicular lymphoma (FL) is a common indolent non-Hodgkin lymphoma characterized by frequent rela...
AI-based decision support (M-BOT) for treatment selection in multiple myeloma
Abstract Background: Therapeutic decision-making in hematology, particularly for patients with multiple myeloma (MM), is often characterized...
A multicenter real-world analysis (RWA) of primary cutaneous anaplastic large cell lymphoma (PCALCL) treated in the era of targeted therapies
Abstract Introduction: The real-world outcomes in patients (pts) with PCALCL in the era of targeted therapies like Brentuximab Vedotin (BV)...
Identification of persister cells and evolution of tumor clones during immunotherapy and at minimal residual disease timepoints decoded by single-cell whole-genome sequencing in multiple myeloma
Abstract Background: Mutations in cancer driver genes and target antigens are associated with poor prognosis in multiple myeloma (MM), but th...
Parental replacement therapy with iron dextran or ferumoxytol in patients with iron defiency
Abstract Background: Replacement therapy in patients with iron deficiency can be administered via oral or parenteral route. Two intravenous...
Superior outcome from frontline cord blood transfusion combined HLA-full-matched unrelated donor hematopoietic stem cell transplantation for aplastic anemia
Abstract Aplastic anemia (AA) is a bone marrow failure syndrome caused by aberrant immune responses and is associated with high mortality an...
Snh-119014, a novel pyruvate kinase activator, enhances ATP production and reduces oxidative stress in erythroid cells from patients with β-thalassemia major
Abstract Introduction: Oxidative stress contributes significantly to ineffective erythropoiesis and reduced red blood cell (RBC) survival in...
A protein S-targeting monoclonal antibody, VGA039, improves both primary and secondary hemostatic activity of von Willebrand disease patient blood in an ex vivo vascularized hemostasis-on-a-chip
Abstract Introduction: Protein S (PS) is a cofactor for two important endogenous anticoagulant proteins, tissue factor pathway inhibitor α (...
Five year follow-up of donor-derived CD7 CAR T-cell therapy for r/r T-cell acute lymphoblastic leukemia
Abstract Background:CAR T-cell therapy for B-cell leukemia has matured significantly. However, studies on the safety and efficacy of CAR-cel...
Impact of pre-transplant functional status and comorbidities on outcomes in individuals with multiple myeloma undergoing autologous hematopoietic cell transplantation
Abstract Background: Multiple myeloma (MM) is a hematologic malignancy for which autologous hematopoietic cell transplantation (auto-HCT) in...
Chidamide-based epigenetic therapy for relapsed/refractory Acute Myeloid Leukemia
Abstract Introduction: Effective treatment options for relapsed or refractory acute myeloid leukemia (R/R AML) remain limited....
Synergizing sickle cell: Extending healthcare dollars through a specialized sickle cell program
Abstract Hemoglobinopathy as a whole affects approximately 1.5% of Americans. Sickle Cell Disease (SCD) affects over 100,000 people in the U...
BNP promotes platelet activation and thrombosis via its receptor natriureticpeptide receptor-a (NPRA): A paradigm shift from biomarker to effector
Abstract Background-B-type natriuretic peptide (BNP) is a cardiac-derived vasodilator and a well-established biomarker for heart failure. El...
Artificial intelligence for predicting transformation of monoclonal gammopathy of undetermined significance to multiple myeloma: A systematic review and meta-analysis
Abstract Objectives The purpose of this study was to assess the empirical evidence of the efficacy of AI in predicting th...
Heterogeneous clinical outcomes within contemporary risk strata: A genomic reappraisal of 2022 ELN in AML
Abstract Background: Acute myeloid leukemia (AML) remains a prognostically heterogeneous malignancy despite advances in molecular risk strat...
First-line pola-R-CHP in diffuse large B cell lymphoma: A single-center real-world data analysis
Abstract Objective: To evaluate the efficacy of first-line Pola-R-CHP therapy in patients with high-risk diffuse large B-cell lymphoma (DLBC...
Peripheral blood immune profiling in newly diagnosed multiple myeloma: Associations with MRD status and high-risk cytogenetics
Abstract Background: Both cytogenetic risk and measurable residual disease (MRD) status are the most important clinicall...
Trial in progress: Treatment of CNS lymphoma with zanubrutinib and tislelizumab: A phase ib/II investigator-initiated study
Abstract Background: Outcomes of patients with relapsed / refractory (r/r) central nervous system (CNS) lymphoma are ext...
Peripheral circulating myeloma cells accurately identify bone marrow MRD positivity in multiple myeloma patients receiving CAR T or autologous transplant
Abstract Depth of response assessed by minimal residual disease (MRD) assays is an important prognostic factor in multiple myeloma (MM). Bon...
Anti-BCMA CAR T-cell therapy in relapsed/refractory multiple myeloma with extramedullary disease: Comparative outcomes and evolving strategies
Abstract BACKGROUND/OBJECTIVE: Extramedullary disease (EMD) in relapsed/refractory multiple myeloma (RRMM) has aggressiv...
Multi-omics analysis identifies neutrophil degranulation as a PSMD3-regulated pathway in FLT3-mutated AML
Abstract Introduction: Acute myeloid leukemia (AML) is a heterogeneous disease characterized by the aggressive accumulation of immature stem...
G6PD-deficiency is associated with improved survival in patients with AML treated with venetoclax and azacitidine
Abstract Glucose-6-phosphate dehydrogenase (G6PD) deficiency impairs cellular redox balance through reduced NADPH production and is the most...