Blood
Articles in this Issue
The role of pentamidine for pneumocystis jirovecii prophylaxis in allogeneic hematopoietic stem cell transplantation: A systematic review and meta-analysis
Abstract Background: Pneumocystis jirovecii pneumonia (PJP) is a life-threatening opportunistic infection in allogeneic hematopoietic cell t...
Fecal microbiota transplantation ameliorates refractory chronic graft-versus-host disease through short-chain fatty acids-treg axis in allogeneic hematopoietic cell transplant recipients
Abstract Disruption of the intestinal microbiota plays a crucial role on the initial and development of graft-versus-host disease (GVHD). Fe...
Metabolomics profiling and machine learning prediction of efficacy and prolonged cytopenia in patients with large B-cell lymphoma undergoing CAR-T therapy
Abstract NTRODUCTION Achieving complete response (CR) within 3 months after CAR-T therapy is a key early indicator for predicting the long-t...
Efficacy, quality of life, and safety of non-clotting factor prophylaxis in Hemophilia A and b: A meta-analysis across inhibitor status
Abstract Introduction: Hemophilia A and B are among the most common inherited bleeding disorders in humans with lifelong risk of spontaneous...
Extended validation of the RR6 prognostic model at 6 and 12 months in primary and secondary myelofibrosis patients treated with ruxolitinib
Abstract Introduction Ruxolitinib has improved outcomes in both primary and secondary myelofibrosis (MF), though resistance or intolerance o...
Systematic review on the diagnostic evaluation of pediatric evans syndrome
Abstract Background: Evans syndrome (ES) is a complex disorder of multi-lineage autoimmune cytopenias and is often a chr...
Patient reported outcome design, conduct and reporting in australasian leukaemia & lymphoma group (ALLG) cooperative group trials
Abstract Introduction: Patient reported outcomes (PROs) are recognised as critical components of clinical trials (CT) in...
The efficacy and safety of pirtobrutinib in patients with CLL/SLL: A phase 2 dose optimization trial in progress
Abstract Introduction: The treatment landscape for patients with chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) has...
Adverse events in Relapsed/Refractory multiple myeloma (RRMM) patients receiving bi-specific T-cell antibodies (BsAbs): A systematic review and meta-analysis of real-world evidence
Abstract Introduction: Bi-specific T-cell antibodies (BsAbs)—a type of immunotherapy used to treat relapsed/refractory multiple myeloma (RRM...
Safety and efficacy analysis of IV iron formulations in children: Results from a large pediatric cohort
Abstract Introduction Iron deficiency (ID) is common in children, mostly due to dietary insufficiency or heavy menstrual...
Increased incidence of secondary malignancies after autologous stem cell transplantation in follicular lymphoma patients: Long-term results of the FIL-FLAZ12 Phase III randomized trial
Abstract Introduction Registry data, including European Society for Blood and Marrow Transplantation (EBMT) data (Petten...
Phase II study of reparixin in patients with myelofibrosis. myeloproliferative neoplasms research consortium (MPN-RC) 120 trial
Abstract Background/rationale Primary myelofibrosis (PMF) and post-polycythemia vera/essential thrombocythemia (Post-PV/ET MF) (collectively...
Patient engagement and perceived impact of clinical trials in hematology
Abstract Clinical trials are basic to therapeutic innovation and a vital opportunity for patients to access cutting-edge therapies. But how...
Circulating CD161high CD8 T cells at leukapheresis are associated with reduced risk of progression at 12 months (PFS12) in large B-cell lymphoma treated by axicabtagene ciloleucel: Results from the Phase 2 alycante study (LYSA)
Abstract Introduction: CAR T-cells have significantly improved the prognosis of patients with relapsed or refractory (R/R) large B-cell lymp...
Ex vivo expanded adaptive NK cells in combination with a bispecific NK cell engager targeting BCMA for synergistic control of multiple myeloma
Abstract T cell-based therapies have transformed the treatment landscape for multiple myeloma (MM). However, most patients receiving autolog...
In Vivo CAR-t generation using an engineered lentiviral vector platform targeting BCMA, CD19 and CD20.
Abstract Autologous chimeric antigen receptor (CAR) T cell therapies have revolutionized the treatment of B cell malignancies and multiple m...
Incidence and risk factors of hemophagocytic lymphohistiocytosis after bispecific antibody therapy in hematologic malignancies: Insights from a global real-world cohort
Abstract Background: Hemophagocytic lymphohistiocytosis (HLH) is a rare but life-threatening hyperinflammatory syndrome. It is increasingly...
Interferon therapy achieves potent reduction in JAK2 allele burden in patients with myeloproliferative neoplasms: A real-world analysis
Abstract Introduction: Myeloproliferative neoplasms (MPNs) are clonal hematopoietic stem cell disorders characterized by aberrant JAK-STAT s...
Integrative proteomics and machine learning identify subtype- and symptom-associated signatures in systemic mastocytosis
Abstract Introduction: Systemic mastocytosis (SM) is a rare clonal disorder marked by the pathological accumulation of mast cells, key effect...
Evaluation of clinical significance of circulating growth differentiation factor-15 levels in patients with gaucher disease
Abstract Background: Gaucher disease (GD) is a rare autosomal recessive genetic disorder resulting from mutations in the GBA1 gene located o...
9-year-old female presenting with l lower leg pain diagnosed with erdheim-chester disease (ECD)
Abstract Background: Erdheim-Chester disease (ECD) is a non-Langerhans histiocytic disorder that commonly includes osteosclerotic lesions of...
Role of therapeutic anticoagulation in kidney transplant recipients with thrombophilia: A systematic review
Abstract Background: Renal allograft thrombosis, though commonly attributed to surgical or anatomical causes, is increasingly linked to inhe...
Influence of HIV status, age and ethnicity on survival in patients with burkitt lymphoma (BL) and diffuse large B cell lymphoma (DLBCL): A real-world nationwide database study
Abstract Introduction: BL and DLBCL are the two most common lymphomas associated with HIV infection. Notably, clinical trials often exclude...
Feasibility of wearable technology for remote monitoring in high-risk adults with sickle cell disease: Baseline data from the SCD-carre trial
Abstract Background: Adults with sickle cell disease (SCD) experience reduced physical capacity due to anemia and cardiopulmonary complicati...
Temporal trends in aplastic anemia mortality across u.S. regions (1999–2020)
Abstract Introduction: Aplastic anaemia is a life-threatening, rare disease with high rate mortality. Even though the pathophysiology of the...