Blood
Articles in this Issue
Real-world study on the impact of continuous treatment dose interruption or reduction of COVALENT BTK inhibitors on efficacy: A 7-year follow-up in chronic lymphocytic leukemia specialized clinics at tertiary hospitals in shanghai, China
Abstract Introduction: Since the introduction of first-generation Bruton tyrosine kinase inhibitors (BTKis) nearly a decade ago, BTKis have...
Impact of antibiotic use in early fever after haploidentical hematopoietic stem cell transplantation with post-transplant cyclophosphamide
Abstract Introduction: Early fever is a frequent complication following haploidentical hematopoietic stem cell transplantation (haplo-HSCT)...
The central role of liver stifness measurement in adults with transfusion dependent thalassemia (TDT) beyond what could be informed by liver iron concentration
Abstract Clinical management of transfusion-dependent β-thalassemia (TDT) is still primarily based on chronic transfusion and iron chelation...
Efficacy and safety of zanubrutinib plus bendamustine-rituximab in newly diagnosed Mantle Cell Lymphoma with TP53 abnormalities or chemotherapy intolerance
Abstract Introduction: Mantle cell lymphoma (MCL) in elderly patients, especially those with TP53 aberrations or who are intolerant to chemo...
Clinical impact of untargeted baseline plasma metabolomics in newly diagnosed diffuse large B-cell lymphoma
Abstract Introduction . Metabolomics is emerging as a promising tool to identify novel prognostic biomarkers in hematological malignancies, b...
Effect of baseline hemoglobin on survival in renal cell cancer patients on tyrosine kinase inhibitors
Abstract Introduction Tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors (ICIs) are widely used in the t...
The efficacy and safety of using low-dose cyclophosphamide, fludarabine and thymoglobulin in allogeneic hematopoietic stem cell transplantation for transfusion-dependent non-severe aplastic anemia：a retrospective study.
Abstract Abstract Objectives:This study aimed to analyse the efficacy of allogeneic hematopoietic stem transplantation(HSCT) for transfusion...
Transfusion independence with momelotinib regardless of baseline erythropoietin levels in the Phase 3 SIMPLIFY-1 trial
Abstract Introduction: Traditional approaches to anemia management in myelofibrosis (MF) include red blood cell transfusions and supportive...
Bridging therapy response and low pre-lymphodepletion plasma cell burden are associated with improved safety and efficacy outcomes of ciltacabtagene autoleucel in multiple myeloma
Abstract Introduction.Ciltacabtagene autoleucel (cilta-cel) is a B-cell maturation antigen (BCMA)-directed chimeric antigen receptor T-cell...
Risk factors for varicella zoster virus reactivation in newly diagnosed multiple myeloma patients undergoing autologous stem cell transplantation
Abstract Multiple myeloma (MM) patients undergoing autologous stem cell transplantation (ASCT) have a cumulative risk between 8 and 20% of v...
Circulating tumour plasma cells in newly diagnosed multiple myeloma: Prevalence, clinical correlates, and phenotypic distinction from bone marrow plasma cells in a south Indian cohort
Abstract INTRODUCTION Multiple myeloma (MM) is a haematological malignancy characterised by the clonal proliferation of plasma cells within t...
Relative mortality in elderly frail patients with newly diagnosed multiple myeloma: Ad-hoc analysis of the Phase 3 IFM 2017-03 trial compared to population-based data in France and implications for the functional cure concept
Abstract Background. Recent improvements in frontline treatments have led to remarkable outcomes in elderly patients with newly diagnosed mu...
Targeted metabolomics identifies a metabolic switch to mitochondrial respiration in antiphospholipid syndrome that drives platelet procoagulant activity
Abstract Introduction Antiphospholipid syndrome (APS), characterized by persistent circulating antiphospholipid antibodies (aPL) is associat...
The evaluation of the HLA-KIR interaction models may predict the NK alloreactivity in haplo-HSCT based on ptcy: Experience of a single spanish center
Abstract INTRODUCTION The reconstitution of NK cells and alloreactivity mediated by KIR receptors after allogeneic trans...
Kilimanjaro challenge: The use of red blood cell functional assessment in a gene-edited sickle cell disease patient to predict response to extreme altitude conditions
Abstract Introduction: Sickle cell disease (SCD) arises from a single nucleotide mutation in the β-globin gene (HBB), producing hemoglobin S...
Humanin-like 8 regulates metabolic fitness and anti-apoptotic programming in CD19 CAR-T cells
Abstract CAR-T cell therapy is a standard treatment for relapsed diffuse large B cell lymphoma (DLBCL); however, many patients fail to achie...
Backtracking the cellular origins of ETV6::RUNX1 childhood acute lymphoblastic leukemia in cord blood (ReCord study)
Abstract Introduction:Childhood leukemia usually develops via a two-hit mechanism, with a preleukemic genomic lesion arising before birth as...
Outcomes of 544 patients with t(6;9) Acute Myeloid Leukemia undergoing allogeneic stem cell transplantation: An EBMT Study on behalf of the acute leukemia working party (ALWP) and the pediatric diseases working party (PDWP)
Abstract Background: The translocation t(6;9)(p23;q34)/DEK::NUP214 defines an adverse-risk subtype of acute myeloid leukemia (AML), for whic...
Allogenic donor-derived cytokine-induced killer (CIK) cells as a safe post-transplant treatment for disease recurrence in the setting of HLA-mismatched donors
Abstract Background Cytokine-induced killer (CIK) cells are in vitro expanded CD3+, CD8+ and CD56+ T cells, sharing both T and NK cell featu...
The formation of cryptococcus neoformans biofilms contributes to the pyroptosis of cerebral microvascular endothelial cells
Abstract Background Cryptococcus neoformans primarily affects non-central nervous systems in immunocompetent individuals, causing pulmonary...
A Phase II study of time-limited treatment with orelabrutinib plus bendamustine and obinutuzumab (OBG) in patients with treatment-Naïve CLL/SLL patients
Abstract Background: FCR (fludarabine, cyclophosphamide, and rituximab) has been demonstrated to improve outcomes in previously untreated Ch...
Identification of genetic loci regulating plasma and platelet factor v expression in mice
Abstract Background:Factor V (FV) is a protein in the coagulation cascade found in two circulating compartments: 80% in plasma and 20% in pl...
Prognostic risk integration for survival modeling (PRISM) in newly diagnosed acute myeloid leukemia treated with venetoclax: a multinational retrospective cohort study
Abstract Background: The 4-gene molecular prognostic risk score (mPRS) improves overall survival (OS) prediction in patients (pts) with newl...
Tonsillar hypertrophy as a rare presentation of chronic lymphocytic leukemia/small lymphocytic lymphoma: A mini-review
Abstract Background Chronic Lymphocytic Leukemia (CLL) is a prevalent adult leukemia that primarily affects individuals over the age of 65....
Improvements in mental health symptoms are associated with improved quality of life over time in adults with sickle cell disease
Abstract Introduction Approximately 40% of individuals with sickle cell disease (SCD) have mental health symptoms including depression and a...