Blood
Articles in this Issue
Stag2 dependent chromatin remodeling enforces the erythroid-specific Gata1 cistrome
Abstract The mechanisms regulating erythropoiesis have been extensively characterized, identifying a complex network of intrinsic and extrin...
Aquired hemophilla a after covid-19 infection in an 5-week old infant
Abstract Clinical Summary: We report a case of a 5 week male with acquired Hemophilia A secondary to SARS-CoV-2 infection (COVID 19). He was...
Performance and clinical utility of germline genetic testing criteria for predisposition to myeloid neoplasms in adults
Abstract Introduction Hereditary hematopoietic malignancies (HHMs) are increasingly recognized as clinically relevant entities due to their...
The limited impact of preexisting rheumatologic diseases on outcomes after allogeneic hematopoietic stem cell transplantation: A nationwide Propensity–Matched analysis
Abstract Background Rheumatologic diseases (RDs), including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and other connect...
A murine monoclonal antibody to integrin αIIbβ3 that inhibits protein disulfide isomerase binding to platelets and platelet aggregation
Abstract L.W. and J.W. contributed equally Introduction: Platelet αIIbβ3 plays a pivotal role in hemostasis and thrombos...
Quantitative clinical pharmacology analysis to support the dose escalation of elranatamab + nirogacestat in the MagnetisMM-4 study
Abstract Background Elranatamab (ELRA) is a bispecific antibody (BsAb) targeting B-cell maturation antigen (BCMA) on myeloma cells and CD3 on...
Dissecting the biology of hairy cell leukemia variant: Insights from whole exome and RNA sequencing
Abstract Introduction: Hairy cell leukemia variant (HCL-v) is a rare aggressive splenic B-cell lymphoma that differs significantly from its...
Flumatinib versus nilotinib as first-line therapy for chronic myeloid leukemia in chronic Phase: A propensity score-matched cohort study
Abstract Background Flumatinib, the first China-developed second-generation tyrosine kinase inhibitor (TKI), shares structural similarities w...
Outcomes for allogeneic transplant in myelofibrosis remain suboptimal in the modern era despite increased use of post-transplant cyclophosphamide and pre-transplant JAK inhibition.
Abstract Allogeneic transplant remains the only curative therapy for patients with primary or secondary myelofibrosis (MF), but outcomes rem...
Developing prediction rules to safely decrease unnecessary head CT scans for pediatric patients with hemophilia presenting with head injuries
Abstract BACKGROUND: Guidelines for managing head injury in pediatric patients with hemophilia (PwH) are limited. The National Bleeding Diso...
Development of a novel CD19/BCMA dual CAR-T for autoimmune diseases
Abstract CD19 and BCMA CAR-T therapies have recently gained widespread application in the field of autoimmune diseases, demonstrating remark...
Efficient prime editing of human hematopoietic stem cells corrects the recurrent SBDS C.258+2T>C mutation and recovers engraftment potential in shwachman-diamond syndrome
Abstract Shwachman-Diamond syndrome (SDS) is an inherited bone marrow failure disorder associated with myelodysplastic syndrome and acute my...
Multi-dimensional adherence patterns in rare haematological conditions: Longitudinal analysis of real-world patient-reported outcomes
Abstract Background Capturing longitudinal patient-reported outcomes (PROs) beyond healthcare visits is central to understanding real-world...
We're not talking about sex: Hematopoietic stem cell transplant provider practices and barriers to sexual health discussions with adolescents and young adults
Abstract Introduction: Sexual health is an important part of overall well-being for adolescents and young adults (AYAs) after hematopoietic...
A predictive model for treatment failure in CLL/SLL patients receiving BTK inhibitor: A multi-center retrospective study
Abstract Background: Despite the significant improvement in outcomes for chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) p...
Closing the gap in vaso-occlusive episode triage for sickle cell patients: A quality improvement initiative
Abstract Introduction: Painful vaso-occlusive episodes (VOE) are the most common complication prompting emergency care in patients with sick...
Oncogenic ASPP2κ: A novel regulator of drug resistance and tumor progression in multiple myeloma
Abstract Treatment options for multiple myeloma (MM) have improved significantly in recent years. Nevertheless, therapy resistance occurs in...
Divergent exhaustion networks define memory CD8+ T cell subset fate under chronic stimulation and reveal targets for epigenetic reprogramming
Abstract T cell exhaustion (TEX) impairs the efficacy of cancer immunotherapies. Following activation from an acutely resolved infection or...
Phase II frontline chemolight R-pola-glo trial induces high and durable response rates in elderly and medically unfit/frail patients with aggressive B-cell lymphoma
Abstract Background Diffuse large B-cell lymphoma (DLBCL) is the most common aggressive lymphoma in adults, predominantl...
Evaluation of response assessment in chronic lymphocytic leukaemia using measurable residual disease by flow cytometry: Prospective observational study.
Abstract Background : Measurable residual disease (MRD) status has recently emerged to evaluate treatment efficacy, predict long-term outcom...
Partnering with patients to guide the development of impactful educational resources for warm autoimmune hemolytic anemia (wAIHA)
Abstract Introduction: Warm autoimmune hemolytic anemia (wAIHA) is a rare, life-threatening, relapsing, autoantibody-driven disease associat...
Twenty-five-year mortality trends of aplastic and secondary anemias in diabetic adults of the United States (U.S.): A CDC wonder multiple cause of death analysis (from 1999 to 2023)
Abstract Introduction: Aplastic anemia, characterized by bone marrow failure leading to pancytopenia. In parallel, secon...
A novel: Plasma apoptosis assay to demonstrate CLL cell target engagement in first-in-human study of a highly selective oral bcl-2 inhibitor lonitoclax (ZE50-0134)
Abstract Background. B-cell lymphoma 2 (Bcl-2) is a member of the anti-apoptotic Bcl-2 family. Sensitivity to pharmaceutical disruption of B...
Molecular spectrum of alpha thalassemia: An unrecognised blood disorder in Nepal
Abstract Background: Thalassemia and hemoglobinopathies are inherited disorders characterized by impaired hemoglobin synthesis and chronic a...
Clinical features and outcome of Philadelphia chromosome-positive acute lymphoblastic leukemia: A 15-year retrospective study
Abstract Introduction Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) is a common hematological malignancy in adults...