Blood
Articles in this Issue
The effect of breakthrough hemolysis on complement factor h and factor I levels in paroxysmal nocturnal hemoglobinuria
Abstract Paroxysmal Nocturnal Hemoglobinuria (PNH) is characterised by chronic complement-mediated hemolysis. The alternative pathway (AP) o...
RUNX1 mutations define a high-risk biological subset of chronic myelomonocytic leukemia and cooperate with ASXL1 mutations to drive leukemic transformation
Abstract Background: RUNX1 mutations (RUNX1mut) are recurrent alterations in chronic myelomonocytic leukemia (CMML) which promote myeloid bia...
Factors associated with achieving complete response in patients older than 65 years diagnosed with diffuse large b-cell lymphoma in first-line therapy. report from a tertiary center in Mexico city
Abstract Introduction: The prevalence of diffuse large B-cell lymphoma (DLBCL) in the geriatric population has increased in recent decades....
Outcomes with repeat CAR-t cell therapy: A systematic review and meta-analysis
Abstract Introduction: Chimeric Antigen Receptor (CAR) T-cell therapy has transformed the treatment of relapsed or refractory B-cell maligna...
Role of fludarabine exposure on post-transplant outcomes in high-risk β-thalassemia patients undergoing allogeneic HCT with thiotepa/ fludarabine/ treosulfan conditioning
Abstract Fludarabine (Flu) in combination with Treosulfan (Treo) and Thiotepa (Thio) (TFT) has been used as a toxicity-reduced conditioning...
Impact of pulmonary and cardiac comorbidities on cytokine release syndrome incidence in chimeric antigen receptor (CAR) t-treated diffuse large B-cell lymphoma (DLBCL) patients: A real-world data analysis
Abstract Background: CAR T-cell therapies using genetically modified autologous T cells targeting CD19 have been approved for third-line the...
Injectable pentosan polysulfate: A novel cause of heparin-induced thrombocytopenia and stroke
Abstract Introduction: We describe a rare and diagnostically challenging presentation of heparin-induced thrombocytopeni...
A phase 2 open-label study of epeleuton in patients with sickle cell disease
Abstract Background and Significance Sickle cell disease (SCD) is a rare inherited blood disorder caused by a single point mutation in the b...
Front-line treatment of Philadelphia negative B-cell acute lymphoblastic leukemia with hypercvad with blinatumomab
Abstract Introduction: Blinatumomab (Blin), a CD19xCD3 bispecific T-cell engager, is recommended in the consolidation phase of front-line th...
Asciminib pediatric formulation shows a tolerable safety profile in pediatric patients with chronic myeloid leukemia in chronic phase (CML-CP): Second interim analysis from the ASC4KIDS study
Abstract Introduction: Standard of care tyrosine kinase inhibitors (TKIs) improve the outcomes for children with Philadelphia chromosome–pos...
Neutrophil extracellular traps drive myeloproliferation and immune dysfunction in chronic myelomonocytic leukemia
Abstract Background: Chronic myelomonocytic leukemia (CMML) is an aggressive hematologic malignancy characterized by myelodysplastic and mye...
Wstf degradation through nuclear autophagy promotes inflammatory responses in primary myelofibrosis: Implications for XPO1 inhibitor-based therapeutic strategies
Abstract Background: Primary myelofibrosis (PMF) is a chronic myeloproliferative neoplasm characterized by persistent inflammation. Nuclear...
Extracellular vesicle dynamics as biomarkers in sickle cell disease across therapies
Abstract Introduction Sickle cell disease (SCD) is characterized by chronic hemolysis and endothelial dysfunction, driving inflammation and...
Bone marrow adipocytes fuel hematopoietic regeneration via fatty acid release
Abstract In adulthood, hematopoietic stem cells (HSCs) reside in the bone marrow niche, where they are maintained by growth factors such as...
Real-world monotherapy and combination usage of mogamulizumab among patients with mycosis fungoides or Sézary syndrome in the United States
Abstract Introduction Mogamulizumab is approved in the United States (US) for the treatment of adults with relapsed/refractory (r/r) mycosis...
Synergistic efficacy and preliminary molecular mechanisms of venetoclax combined with microtransplantation in the treatment of elderly patients with Acute Myeloid Leukemia
Abstract Background: Elderly patients with acute myeloid leukemia (AML) have poor prognosis, which is attributed to multiple factors includi...
National trends in mortality due to disseminated intravascular coagulation and sepsis: A 21-year analysis of hematologic emergencies in the United States
Abstract Introduction: Disseminated intravascular coagulation (DIC) is a life-threatening coagulopathy frequently associated with sepsis, ma...
Orelabrutinib combined with bendamustine-rituximab or obinutuzumab followed by orelabrutinib maintenance in untreated marginal zone lymphoma (Optimize): A multicenter, single-arm, phase II study
Abstract Background: The absence of a standard first-line treatment for marginal zone lymphoma (MZL) and the toxicities of existing systemic...
Novel diagnostic and prognostic tools for patients with chronic idiopathic neutropenia: Data on a cohort of 266 patients
Abstract Background: Chronic Idiopathic Neutropenia (CIN) is a neutrophil disorder characterized by the persistent and unexplained reduction...
CD 34 stem cell boost in patients with poor graft function after allogeneic hematopoietic stem cell transplantation: Experience from a tertiary care center
Abstract Introduction: Poor hematopoietic reconstitution (PHR), in the form of poor graft function (PGF) is a life-threatening complication...
Characteristics and outcome of composite lymphomas: A synthetic cohort approach
Abstract The coexistence of two distinct lymphoma subtypes within a single patient, either in the same anatomical site (composite lymphoma,...
Real-world selection of fixed-duration versus continuous therapies for treatment-naïve chronic lymphocytic leukemia/small lymphocytic lymphoma
Abstract Introduction: The therapeutic landscape for treatment-naïve (TN) chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL)...
Dissecting clonal hematopoiesis in diffuse large B-cell lymphoma through multi-compartment genomic profiling
Abstract Background: Clonal hematopoiesis (CH) in diffuse large B-cell lymphoma (DLBCL) has been investigated in a limited number of studies...
Evaluating the efficacy of montelukast in reducing the incidence and severity of monoclonal antibodies-associated infusion reactions (Phase II Study)
Abstract Introduction Monoclonal antibodies (MABs) and antibody-drug conjugates (ADCs) are increasingly utilized in hematology-oncology. How...
Real-world assessment of prophylactic anakinra on neurotoxicity after CD19 CAR T-cell therapy in R/R B-cell lymphoma: An inverse probability of treatment weighting analysis
Abstract Introduction Immune effector cell-associated neurotoxicity syndrome (ICANS) is a common toxicity of CD19 CAR T-cell therapy (CAR T)...