Blood
Articles in this Issue
Clinical manifestations, management, and outcomes in patients with triple positive antiphospholipid antibodies
Abstract Introduction Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by arterial, venous, or microvascular thrombos...
Construction and validation of a prediction model for extracorporeal circuit clotting risk during regional citrate anticoagulation in continuous renal replacement therapy for critically ill patients with hematological disorders
Abstract Background: Continuous renal replacement therapy (CRRT) is increasingly employed for critically-ill patients with hematologic disor...
Immune dysregulation in newly diagnosed DLBCL: From clinical observations to molecular mechanisms
Abstract Background: Diffuse large B-cell Lymphoma (DLBCL) is an aggressive malignancy where the tumor immune microenvironment (TME) plays a...
Real-world treatment patterns and clinical outcomes in patients with essential thrombocythemia treated with cytoreductive therapy: A retrospective analysis of electronic health records data
Abstract Background: Essential thrombocythemia (ET) is a rare, chronic myeloproliferative neoplasm characterized by sustained thrombocytosis...
Single-nucleus dissection of peripheral T-cell lymphomas reveals distinct microenvironmental ecosystems and therapeutic vulnerabilities
Abstract Peripheral T-cell lymphomas (PTCL) are aggressive hematologic cancers characterized by complex tumor microenvironments (TME) with r...
IVIG successfully halts a recurrent hyperhaemolysis syndrome in a young patient with sickle cell crisis
Abstract Hyperhaemolysis syndrome is a rare blood transfusion complication putting patients requiring repeat transfusions frequently at risk...
Prospective phase I/II study of CD19-directed CAR-t therapy in relapsed/refractory central nervous system lymphoma: Clinical outcomes and safety profile
Abstract Background: CD19-directed chimerical antigen receptor T-cell (CAR-T) therapy as an immunotherapy has documented significant clinica...
Prospective clinical study on the efficacy and safety of the DCIA±X regimen in treating relapsed/refractory acute myeloid leukemia
Abstract Background: Patients with relapsed/refractory acute myeloid leukemia (R/R AML) face dismal outcomes, highlighting the critical need...
Defining clinical risks of venous thromboembolism in children with intestinal failure
Abstract Introduction Patients with intestinal failure are living longer as the rates of intestinal failure-associated liver disease (IFALD)...
Conserved residues in the GPIbα mechanosensory domain are important for its expression and signaling
Abstract Background: Glycoprotein Ib-IX (GPIb-IX), the primary receptor for von Willebrand factor (VWF) on platelets, mediates initial plate...
Axatilimab in combination with ruxolitinib in patients with newly diagnosed chronic graft-versus-host disease: Interim safety analysis of a phase 2, randomized study
Abstract Introduction: Chronic graft-versus-host disease (cGVHD) is a leading cause of morbidity and non-relapse mortality in patients who u...
Integrating thymic expression patterns into tumor antigen selection enhances immunotherapy design and stratifies clinical responses to immunotherapies
Abstract Introduction: Tumor associated antigens (TAAs; non-mutated proteins overexpressed in cancer relative to healthy tissues) are promis...
Degradation of IgG autoantibodies associated with platelet disorders by a half-life extended IgG protease
Abstract Multiple blood disorders are mediated by immunoglobulin G (IgG) autoantibodies that recognize self-antigens associated with platele...
Talquetamab outcomes from practice outside of clinical trials: The bital study
Abstract Introduction: Talquetamab (Tal) is the first bispecific antibody (BsAb) that targets the G protein-coupled receptor family C group...
Other cancers in patients with chronic lymphocytic leukemia/SMALL lymphocytic lymphoma
Abstract Introduction: Patients diagnosed with chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL/SLL) exhibit an elevated risk...
Prognostic value of minimal residual disease detection by circulating tumor DNA in Hodgkin lymphoma.
Abstract INTRODUCTION: First-line treatment is curative in more than 80% of patients with Hodgkin lymphoma (HL). However, ~20% of cases relap...
FBXO7 通过靶向 TMED10 进行泛素介导的降解和激活 wnt 信号传导来促进 T-ALL 的化疗耐药性
Abstract Acute T-cell lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy derived from T-lineage progenitor cells, accoun...
FluMel100 with post-transplant cyclophosphamide: A safe and effective regimen for patients aged ≥75 years with MDS and AML
Abstract Background: Allogeneic hematopoietic stem cell transplantation (allo-HCT) remains the only curative treatment for many older adults...
AI-enhanced image analysis of point of care tests for sickle cell disease screening in Uganda – a pilot cluster randomized trial
Abstract Background: In Sub Sahara Africa (SSA) where the burden of Sickle cell disease (SCD) is highest, newborn screening for SCD is not w...
Genetic characteristics and treatment outcomes of pediatric acute lymphoblastic leukemia patients with CRLF2 rearrangements
Abstract Background. Acute lymphoblastic leukemia (ALL) with CRLF2 rearrangements (CRLF2r) is one of the most common subtype of BCR::ABL1-li...
Beta thalassemia major and pregnancy outcomes: Evidence of severe transfusion burden and iron overload complications in a national cohort
Abstract Introduction: Beta thalassemia major (Cooley's anemia) results from a severe reduction or absence of beta-globin chain synthesis, l...
Real world outcomes of zanubrutinib monotherapy for CLL/SLL focusing on treatment discontinuation and BTKi switching: A single center retrospective analysis
Abstract Introduction: Zanubrutinib as a second generation bruton tyrosin kinase inhibitor (BTKi) has become the standard of care for both f...
Preliminary analysis of the role of magnesium in transplant-associated thrombotic microangiopathy via complement activation pathways
Abstract Objective: This study aimed to retrospectively analyze the clinical features, potential risk factors, and prognosis of patients dia...
The safety and efficacy of pirtobrutinib in adults with immune thrombocytopenia: A phase 1/2 dose-finding study in progress
Abstract Introduction: Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by reduced platelet counts and increased risk o...
The heights of iron absorption: Erythrocytosis in patients with heterozygous HFE mutations at altitude
Abstract Background: Hemochromatosis (HC) is a disorder characterized by increased iron absorption from the intestines a...