Blood
Articles in this Issue
Impact of extranodal involvement on bispecific antibody (BsAb) outcomes in patients with large B-cell lymphoma (LBCL)
Abstract Introduction BsAbs have emerged as a promising therapeutic option for patients with LBCL, but their outcomes may be impacted by a w...
Real-world treatment patterns and survival outcomes in second and third line settings in large B-cell lymphoma (LBCL)
Abstract Introduction: Despite the proven efficacy of chimeric antigen receptor T-cell (CAR T) therapy for patients with relapsed or refract...
Real-world experience with prophylactic/preemptive, and therapeutic donor lymphocyte infusion (DLI) after allogeneic hematopoietic cell transplantation: A 15 year experience of single-center Study from Latin America
Abstract Relapse after allogeneic hematopoietic cell transplantation (allo-HCT) remains a major cause of treatment failure and is associated...
Area deprivation index does not influence survival in patients with lower-risk myelodysplastic syndromes at a major cancer center
Abstract Introduction: The Area Deprivation Index (ADI) is a well-validated tool for assessing health equity (Powell et al., Forefront, 2023...
Survival outcomes and mortality-to-incidence ratio (MIR) in refractory anemia with excess blasts: A retrospective overview
Abstract Introduction Myelodysplastic syndrome (MDS) is a heterogeneous clonal disorder of hematopoietic stem cells characterized by dysplas...
Shared mechanisms of resistance to zanubrutinib and ibrutinib via EGR1 and DNMT3A in mantle cell lymphoma
Abstract Mantle cell lymphoma (MCL), a B-cell malignancy comprising ~6% of non-Hodgkin lymphomas, remains incurable due to frequent relapse...
Treatment practices and outcomes of advanced stage classical Hodgkin lymphoma in India: An analysis from the hematology cancer consortium
Abstract This retrospective study evaluated treatment practices and outcomes in patients with advanced stage classical Hodgkin lymphoma (cHL...
Pomalidomide, rituximab, and orelabrutinib in combination with polatuzumab vedotin for newly diagnosed diffuse large B-cell lymphoma in elderly, unfit, or frail patients:a prospective phase II study
Abstract Background The management of newly diagnosed diffuse large B-cell lymphoma (DLBCL) in elderly, unfit or frail patients requires car...
Chromomycin A2 exhibits antileukemic effects by coordinated disruption of survival pathways
Abstract New therapies for acute leukemias are urgently needed due to the high relapse rates and the frequent development of resistance to c...
Allogeneic hematopoietic stem cell transplantation for myelofibrosis; Patterns, treatment and outcome after relapse and long-term follow up.
Abstract Introduction Allogeneic hematopoietic stem Cell transplantation (HSCT) is the only potentially curative approac...
Unique NK-like T cell population identified in UBA1mt cells in vexas associated with IL-8 mediated activity and cytotoxic response pathways
Abstract Introduction: VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) is an aggressive auto-inflammatory disorder defined...
Frontline tyrosine kinase inhibitor selection influences eventual treatment-free remission eligibility and sustained treatment-free remission: A registry analysis of patients treated at CML referral sites in Australia
Abstract Background For patients diagnosed with chronic myeloid leukemia (CML), the prospect of eventual treatment-free...
Curing Hemoglobin H-Constant Spring through Base Editing of Autologous CD34+ Hematopoietic Stem and Progenitor Cells
Abstract Background: Hemoglobin H Constant Spring (HbH-CS) (–/αCSα) is the most common non-deletional α-thalassemia that can lead to severe...
MTHFD2 is a selective metabolic vulnerability in AML that supports mitochondrial redox homeostasis and venetoclax resistance
Abstract Dysregulation of mitochondrial biology is a common occurrence in acute myeloid leukemia (AML) and is often associated with chemothe...
Immune biomarkers of increased risk of infection in multiple myeloma (MM)
Abstract Background: Infections are one of the leading causes of morbidity and early mortality in MM. Preventing infections is paramount and...
Automated identification and quantification of myeloblasts among myeloid lineage cells on bone marrow biopsy using deep learning aligns with hematopathologist readings in patients with Acute Myeloid Leukemia and high-risk myelodysplastic syndrome
Abstract Background: Assessing myeloblast counts in bone marrow biopsy (BMBx) and aspiration is essential for diagnosis and disease status e...
Impact of obesity on CRS and icans in patients with multiple myeloma receiving bispecific antibodies: A real-world analysis
Abstract Background: Bispecific antibodies (BsAbs) are novel immunotherapeutic agents used for treatment of various hematologic malignancies...
Carfilzomib Augmented with high-dose melphalan conditioning regimen Enhances Response in patients with multiple myeloma eligible for ASCT：an investigator-initiated, prospective, multicenter study
Abstract Introduction:While high-dosed melphalan (HDM) remains the standard conditioning regimen for autologous stem cell transplantation (A...
Assessment of thrombotic risk and pathophysiological mechanisms of splenectomy-associated hypercoagulability in patients with immune thrombocytopenia
Abstract Immune thrombocytopenia (ITP) is an autoimmune disease characterized by isolated thrombocytopenia in the absence of an alternative...
Bispecific antibodies serve as a safe and effective bridging therapy prior to CD19 CAR T-cell therapy/combinational therapy of CD19 CAR-T cell and HDT/ASCT in patients with R/R DLBCL
Abstract Background: Bispecific antibodies (BsAbs) and chimeric antigen receptor T-cell (CAR-T) therapy are highly regarded immunotherapeuti...
Phase I trial of a novel first-in-class drug ONC201 as a post-transplant maintenance for acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS)
Abstract Background: Relapses of AML and MDS remain the principal cause of mortality after allogeneic hematopoietic cell transplantation (HC...
Adult-onset hemophagocytic lymphohistiocytosis triggered by sars-cov-2 and EBV coinfection: A diagnostic challenge resolved with the HLH-94 protocol
Abstract Background Hemophagocytic lymphohistiocytosis (HLH) is a rare, quickly progressive immune activation syndrome, more frequently reco...
Mapping the immune checkpoint receptor-ligand landscape in newly diagnosed multiple myeloma may help prioritize patients for immune checkpoint inhibitor therapy
Abstract Background: Recent clinical trials of immune checkpoint inhibitors (ICI) in multiple myeloma (MM) demonstrated the need to prioritiz...
Rapid hematologic germline testing using hair follicle-derived DNA for germline predisposition and inherited marrow failure states
Abstract Background: Germline predisposition states (GPS), including inherited bone marrow failure syndromes (IBMFS) are seen in 5-10% of ind...
Prime Editing–Mediated BCL-2 hematopoietic stem cell shielding as a strategy for leukemia therapy
Abstract The anti-apoptotic B-cell lymphoma 2 (BCL-2) protein, a key regulator of cell death, is frequently overexpressed in hematological m...