Blood
Articles in this Issue
Vedolizumab for steroid-refractory gastrointestinal acute graft-versus-host disease: A real-world VAST study
Abstract Background: Steroid-refractory (SR) acute graft-versus-host disease (aGVHD) is the major cause of early mortality after allogeneic...
Patient and clinician perspectives on the diagnosis and management of polycythemia vera: Results from concurrent surveys
Abstract Background: Polycythemia vera (PV) is a chronic, JAK2-mutated myeloproliferative neoplasm (MPN) marked by erythrocytosis, increased...
Impact of pre- and post-transplant transfusion requirements on outcomes in severe aplastic anemia patients
Abstract Background: Severe Aplastic Anemia (SAA) is well recognized life threatening hematological disorder characterized by pancytopenia w...
PSF3 recruits DNA polymerase theta (Polθ) to stalled replication forks to promote DNA repair and survival of myeloid malignant cells.
Abstract DNA replication is constantly challenged by DNA damage and other intrinsic and extrinsic stresses collectively termed replication s...
Locally deployed large language models for automated data curation in allogeneic hematopoietic stem cell transplantation
Abstract Background: Baseline and outcome data for patients undergoing hematopoietic stem cell transplantation (HCT) are required to be repo...
INSIGHT: A baseline laboratory profile independently predicts outcomes and demonstrates superiority of lisocabtagene maraleucel (liso-cel) over standard of care (SOC) in second-line (2L) large B-cell lymphoma (LBCL) regardless of baseline profile
Abstract Introduction: CD19-directed CAR T cell therapies have transformed the treatment of patients with R/R LBCL, but the field is still d...
Single-cell immune landscape associated with isatuximab, carfilzomib, lenalidomide, and dexamethasone induction efficacy in newly diagnosed myeloma
Abstract Introduction: Quadruplet regimens combining CD38-targeting monoclonal antibodies, such as Isatuximab or Daratumumab, with proteasome...
The long non-coding RNA SMART regulates human megakaryopoiesis by modulating rRNA processing in the nucleolus
Abstract The process of megakaryopoiesis is complex and regulated by cytokines, transcription factors and non-coding RNAs. Long non-coding R...
Targeted antenatal screening and prevention of hemoglobinopathies inindia: Outcomes from a multi-state implementation of the sankalp model
Abstract Hemoglobinopathies constitute a substantial public health concern in India, with estimates suggesting 100,000–1...
Integrating oncofertility: Contraceptive guidance in chronic lymphocytic leukemia
Abstract Background: Chronic lymphocytic leukemia (CLL) is a hematological malignancy that causes uncontrolled growth of white blood cells....
Burden and outcomes of CAR T-cell therapy toxicities in DLBCL, multiple myeloma, and B-ALL: A nationwide analysis
Abstract Background: Chimeric antigen receptor (CAR) T-cell therapy has transformed the treatment of blood cancers, resu...
Revealing oncogenic enhancer regulation by epigenomic profiling of multiple myeloma and plasma cell leukemia patient samples
Abstract Multiple myeloma (MM) and its aggressive subtype plasma cell leukemia (PCL) are transcriptionally-driven hematological malignancies...
Higher busulfan cumulative exposure predicts better thalassemia-free survival in patients with beta thalassemia undergoing HCT with busulfan-cyclophosphamide containing conditioning regimen
Abstract Busulfan systemic exposure has been shown to influence HCT outcomes, and adjusting the doses to achieve target systemic exposures h...
Outcomes of stem cell boost (SCB) versus supportive care alone for prolonged cytopenias after chimeric antigen receptor T cell therapy (CAR-T) in relapsed/refractory multiple myeloma (RRMM): A muli-center real-world analysis
Abstract Background: Prolonged cytopenias are a well-recognized complication following CAR-T therapy, leading to increased morbidity and hea...
Efficacy and safety observation of luspatercept for refractory anemia associated with hematologic malignanciesluspatercept治疗血液系统恶性肿瘤相关难治性贫血的疗效和安全性观察luspatercept 改善与血液系统恶性肿瘤相关的难治性贫血的疗效和安全性：一项观察
Abstract Background: Patients with hematologic malignancies often experience anemia of varying severity. This anemia imp...
Re-treatment of relapse in elderly AML with time-limited venetoclax-based regimen: A case report and literature review.
Abstract Background Relapse in elderly AML remains a significant challenge. In VIALE-A, 52% and 74% of participants (age...
Accurate quantification of lowly expressed SBDS by integrating pacbio iso-seq long-read and illumina short-read sequencing
Abstract Introduction PacBio Iso-Seq long-read sequencing enables full-length transcript identification, providing high-...
FBXO3-mediated DUSP9 ubiquitination reprograms MAPK signaling to eradicate tyrosine kinase inhibitor-resistant CML stem cells
Abstract Purpose: Discovering new therapeutic targets to overcome tyrosine kinase inhibitors (TKIs) resistance and clear leukemic stem cells...
Uncovering survival-linked genes in DLBCL: A transcriptomic analysis of 1,311 patients
Abstract Background: Diffuse-Large B-cell Lymphoma (DLBCL) is a heterogeneous disease with outcomes influenced by various clinical and molec...
Limitations of the IWG-MRT/ELN response criteria in defining post-transplant remission and clinical success in patients with myelofibrosis: A retrospective study
Abstract Background Allogeneic hematopoietic cell transplant (alloHCT) remains the only curative therapy for myelofibrosis (MF). Consensus-b...
Newborn screening for sickle cell disease in a hospital setting in luanda, Angola: Local implementing learning from an international consortium
Abstract Early diagnosis of Sickle Cell Disease (SCD) is critical to reducing mortality and morbidity in affected children; however, it rema...
The cns-IPI score is predictive of severe immune effector cell-associated neurotoxicity after axicabtagene ciloleucel treatment in patients with large B-cell lymphoma
Abstract Background. Chimeric antigen receptor (CAR) T-cell therapy has significantly improved the prognosis of patients with relapsed/refra...
Upfront continuous BTK inhibitor (BTKi) versus time-limited venetoclax-BTKi combinations in CLL across IGHV subgroups: Results of an indirect analysis
Abstract The optimal first-line treatment for patients with treatment-naïve (TN), TP53 wild-type chronic lymphocytic leukemia (CLL) remains...
Single-cell transcriptomic analysis reveals impaired immune profiles in elderly AML patients
Abstract Background Elderly acute myeloid leukemia (AML) patients have poorer survival than younger individuals, a difference not fully expl...
Temporal trends in treatment patterns and overall survival for multiple myeloma management in Taiwan using the national health insurance claims database
Abstract Introduction: The incidence and prevalence of multiple myeloma (MM) is increasing in Asian countries. In Taiwan, increased MM incid...