Blood
Articles in this Issue
Dara-vd vs vrd: A breakthrough in newly diagnosed multiple myeloma treatment — superior survival and safety profiles
Abstract Effective induction regimens are critical for improving outcomes in newly diagnosed multiple myeloma (NDMM). Bortezomib, lenalidomi...
Zanubrutinib plus R-CHOP versus R-CHOP as first-line therapy in double-expressor DLBCL: A multicenter, propensity score matched retrospective study
Abstract Background: Double-expressor diffuse large B-cell lymphoma (DE-DLBCL), characterized by MYC and BCL2 protein overexpression without...
Protein arginine methyltransferase 1 is required for megakaryocyte-mediated inflammatory response
Abstract Background: Megakaryocytes (MKs) are heterogeneous, with one subgroup known as immune MKs, which express immune regulatory transcri...
The evolution to hepta-refractory myeloma involves sequential loss of CD38, BCMA and GPRC5D
Abstract Introduction: No other hematologic malignancy has seen more drug approvals than multiple myeloma (MM). Yet, MM remains largely incu...
In depth characterization of autologous infused bhv-1100 armored memory-like NK cells in MRD+ multiple myeloma patients receiving autologous stem cell transplant
Abstract Introduction/Background: Minimal residual disease (MRD) negative complete response portends better prognosis in multiple myeloma (M...
Clinical and demographic characteristics of MYH9-related disorders patients: A comprehensive analysis of 16 cases from a single center
Abstract Introduction: MYH9-related disorders are rare inherited platelet disorders which are characterized by macrothrombocytopenia with or...
Safety and efficacy of post transplant cyclophosphamide vs tacrolimus plus methotrexate for gvhd prophylaxis in myelofibrosis
Abstract Background In patients with myelofibrosis (MF) undergoing allogeneic hematopoietic cell transplantation (allo-HCT), graft-versus-ho...
Lymphocyte kinetics as a predictor of clinical outcomes following CAR-T therapy for non-Hodgkin lymphoma
Abstract Introduction - Chimeric antigen receptor (CAR) T cell therapy has become a highly effective salvage option for patients with relaps...
Post-operative thrombocytopenia in on- versus off-pump coronary artery bypass grafting
Abstract Background: Thrombocytopenia is a common post-operative finding in major surgeries including coronary artery bypass grafting (CABG)...
Development of predictive relapse indicators for myeloma T cell engagers (PRIME) model for myeloma patients receiving BCMA- and GPRC5D-targeting T cell engagers
Abstract Introduction: T cell engagers (TCEs), particularly those targeting B-cell maturation antigen (BCMA) and G-protein coupled receptor c...
The outcomes of patients who are relapsed or refractory to menin inhibitors is poor with a limited overall survival
Abstract Introduction: Menin is essential for leukemogenesis in KMT2A-rearranged (KMT2Ar) and Nucleophosmin 1-mutated (NPM1c) AML. Menin inh...
Error-corrected sequencing to quantify clonal hematopoiesis in breast cancer survivors treated with metformin in a randomized, placebo controlled, prospective clinical trial
Abstract BACKGROUND: Targeting clonal hematopoiesis (CH) in an interventional clinical study involves significant challenges including: a la...
Dose Escalation shows no benefit compared to continuing ABVD in Hodgkin's lymphoma patients with an interim PET deauville score of 4
Abstract Introduction: Interim Fluorodeoxyglucose positron emission tomography (PET) conducted in patients with classic Hodgkin's Lymphoma (...
Promising efficacy of BI-1206, an antibody targeting FcγRIIB in combination with rituximab and acalabrutinib in R/R NHL patients NHL
Abstract Background: Anti-CD20 antibodies like rituximab are crucial for treating non-Hodgkin's B-cell lymphoma. However...
EB2023 primes mitochondria for BCL2 dependence and induces pyroptotic cell death via AMPK signaling and the unfolded protein response
Abstract The F1 catalytic domain of ATP synthase performs the final and pivotal step of oxidative phosphorylation (OXPHOS). EB2023 is a sele...
Mitoxantrone hydrochloride liposome, gemcitabine, vinorelbine with or without anti-CD20 antibody (GVM±CD20) in patients with relapsed or refractory aggressive non-Hodgkin's lymphoma: A prospective, multicenter, Phase Ⅱ study
Abstract Background: Platinum-based salvage chemotherapy is the most widely used treatment approach for relapsed or refr...
Dysregulation of the complement system in immune thrombocytopenia
Abstract Background Primary immune thrombocytopenia (ITP) is a rare acquired autoimmune disease characterised by a destruction and impaired...
Ven+FluBu2 with ptcy/tac/MMF RIC transplant followed by venetoclax/azacitidine maintenance for high-risk MDS/AML
Abstract Background: We previously demonstrated that incorporating venetoclax (Ven) into reduced intensity conditioning (RIC) chemotherapy f...
Randomized comparison of ponatinib versus imatinib in combination with chemotherapy in patients 55 years of age and older with newly diagnosed ph+ ALL: Molecular response and initial outcome analysis of the EWALL PH03 Study
Abstract BCR :ABL1 tyrosine kinase inhibitors (TKIs) plus reduced intensity chemotherapy are considered standard of care for older patients (...
IDH2 R172 mutation is associated with improved survival in IDH-mutated AML/MDS patients undergoing allogeneic stem cell transplantation: A geth-TC multicenter study
Abstract Introduction: Mutations in isocitrate dehydrogenase (IDH1 and IDH2) occur in approximately 15–20% and 5-15% of AML and MDS patients...
Incidence of cardiac events associated with next-generation bruton tyrosine kinase (BTK) inhibitors compared to control in hematologic malignancies: A meta-analysis of randomized trials
Abstract Background: Bruton tyrosine kinase inhibitors (BTKi) have revolutionized the treatment of B-cell malignancies b...
Correlation of flow cytometry ogata score with cytogenetic abnormalities in myelodysplastic syndromes.
Abstract Background and Aims: Flow cytometry (FCM) is a fast valuable tool for detecting dysplasia in the diagnosis of MDS, with Ogata score...
Two decades of pregnancy outcomes in women with CML: Insights from a real-world single-center cohort
Abstract Background: The advent of tyrosine kinase inhibitors (TKIs) has transformed Chronic Myeloid Leukemia (CML) from a fatal disease into...
Immune reconstitution with the use of bruton tyrosine kinase inhibitor treatment for patients with Waldenstrom's macroglobulinemia
Abstract Waldenstrom's macroglobulinemia (WM) is a rare B-cell lymphoma defined by immunoglobulin (Ig) M monoclonal gammopathy and lymphopla...
A comparative analysis of efficacy results in clinical trial publications and US prescribing information demonstrates a high degree of discordance in reported response endpoints for Acute Myeloid Leukemia
Abstract The efficacy results in clinical trial publications inform medical practice, build a reliable knowledge base, and provide statistic...