Blood
Articles in this Issue
Real-world comparison of treatment outcomes between BCL2i and 2nd generation BTKi therapy in first-line CLL patients
Abstract Background: First-line (1L) therapies for chronic lymphocytic leukemia (CLL) consist of B-cell lymphoma inhibitors (BCL2i) or Bruto...
Evaluating the efficacy of umbilical cord blood transplantation in TP53-mutated AML/MDS: Encouraging survival outcomes
Abstract Introduction Subtype of MDS/AML carrying TP53 mutations is reported to have poor outcomes , and it often does n...
The use of MYD88 and IGH PCR in the diagnosis and follow up of Βing-neel syndrome
Abstract Background: Bing-Neel syndrome (BNS) is a rare central nervous system involvement of lymphoplasmacytic lymphoma (LPL). The diagnosi...
Rehabilitation needs and clinical associations post CAR T-cell therapy: A retrospective analysis
Abstract Introduction: Chimeric antigen receptor (CAR) T-cell therapy has transformed the management of patients with hematologic malignanci...
Mesenchymal stromal cells in the prophylaxis of graft vs host disease: A meta analysis
Abstract Introduction: Graft-versus-host disease (GVHD) is a major complication following allogeneic hematopoietic stem cell transplantation...
Poor neutrophil recovery following CD19-targeted CAR-T cell therapy predicts inferior outcomes in adult patients with B-cell lymphoma
Abstract Background: Although CD19-targeted CAR-T cell therapy has improved outcomes for relapsed/refractory B-cell lymphoma, persistent neu...
NUP98::NSD1 fusion is associated with poor outcomes in Acute Myeloid Leukemia regardless of co-occurring mutations and treatment regimen
Abstract Introduction: Fusions of the NUP98 gene are a recurring feature in acute myeloid leukemia (AML) and occur in approximately 7% of ch...
A case of co-mutation of SF3B1 and BCR::ABL1 demonstrating an MDS-phenotype
Abstract INTRODUCTION Co-mutations of BCR::ABL1 and clonal hematopoiesis genes are known to occur in chronic myeloid leu...
Longitudinal and integrated analysis of oral and stool microbiome in allogeneic hematopoietic cell transplantation recipients.
Abstract Background: Allogeneic hematopoietic cell transplantation (allo-HCT) is a potentially curative therapy for many benign and malignan...
Comparison of simulated exposure of inotuzumab ozogamicin with and without dose capping in overweight and obese patients with relapsed/refractory acute lymphoblastic leukemia
Abstract Introduction Inotuzumab ozogamacin (InO) is an antibody drug conjugate (ADC) consisting of a CD22-directed monoclonal antibody linke...
Malignancy as a secondary cause of hemophagocytic lymphohistiocytosis: Outcomes and complications, a national inpatient sample analysis from 2016 to 2020
Abstract Background Hemophagocytic Lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome driven by uncontrolled activat...
Deep learning predicts IDH1 mutation status in Acute Myeloid Leukemia from bone marrow smear images
Abstract Acute myeloid leukemia (AML) is a genetically heterogeneous disease. The rise of next-generation-sequencing (NGS) and its incorpora...
Combination of golidocitinib with chidamide for peripheral T-cell lymphoma: Possible mechanisms and therapeutic potential in inhibiting tumor proliferation and modulating the immune microenvironment
Abstract Background: Peripheral T-cell lymphoma (PTCL) is an aggressive and highly heterogeneous subtype of non-Hodgkin's lymphoma (NHL) der...
Evaluation of payment reimbursement models for teclistamab administration and monitoring in the community hospital setting
Abstract Background T-cell engaging bispecific antibodies (BsAbs) have emerged as an important class of immunotherapy for the management of...
A novel IL-11/G-CSF mobilization regimen improves delayed platelet engraftment via targeted megakaryocyte progenitor expansion
Abstract Delayed platelet engraftment (DPE) is a common complication following hematopoietic stem cell transplantation (HSCT) that currently...
Microrna-142 improves IL1RAP CAR-T cell activity in Acute Myeloid Leukemia
Abstract Chimeric antigen receptor (CAR) T cells have shown promise in hematologic malignancies but face major challenges in acute myeloid l...
Patterns of care and outcomes in patients with large B-cell lymphoma not treated with full-dose anthracycline regimens: Outcome analysis from the lymphoma epidemiology of outcomes (LEO) prospective cohort study
Abstract Introduction There is currently no standard-of-care for patients (pts) who cannot tolerate full dose anthracycline regimens in fron...
Detection of mutation in cell-free DNA predicts poor outcomes in adult patients with langerhans cell histiocytosis
Abstract Background and aims: Langerhans cell histiocytosis (LCH) is a rare, heterogeneous histiocytic disease with recurrent MAPK pathway m...
Old mismatched donors are associated with inferior outcomes after allogeneic hematopoietic stem cell transplantation in myelodysplastic syndrome, but not in Acute Myeloid Leukemia
Abstract Introduction: Allogeneic hematopoietic stem cell transplantation (alloHCT) is the only potentially curative option for high-risk my...
Germline osmr mutation drives familial unicentric castleman disease with osteosclerosis
Abstract Objective s: Unicentric Castleman disease (UCD) is a rare lymphoproliferative disorder characterized by localized lymphadenopathy wi...
The somatic DDX41 hot spot mutation (p.R525H) causes skewed differentiation into plasmacytoid dendritic cells in human iPSC and leukemia models
Abstract Germline mutations in the RNA-helicase gene DDX41 cause predisposition to myeloid malignancies (MDS/AML) with a penetrance of 50% b...
Prognostic role of FDG-PET in outcomes of relapsed/refractory large B-cell lymphoma treated with CD3-CD20 directed bispecific antibodies
Abstract Background The use of CD3-CD20-directed bispecific antibodies (BsAb) has significantly improved the outcomes of patients (pts) with...
Dysregulation of fibrinolysis and its relationship with blood cellular indices in acute pulmonary embolism
Abstract Introduction: Pulmonary embolism (PE) is a life-threatening cardiovascular condition characterized by the obstruction of pulmonary...
FerroEVs drive serial propagation of pharmacologically induced ferroptosis in acute leukemia cells
Abstract Pharmacologically induced cell death not only eliminates target cells but also modulates neighboring cells through bioactive molecu...
First report of high-titer FVIII inhibitor development following AAV-mediated gene therapy in Hemophilia A
Abstract Over the past decade, adeno-associated virus (AAV) vector–based gene therapy (GT) has emerged as a major advance in hemophilia A (H...