Blood
Articles in this Issue
Telehealth based virtual consult visits and in-person consult visits provide comparable time to HLA-typing and preliminary donor search in patients referred for allogeneic hematopoietic cell transplantation
Abstract Introduction: Allogeneic hematopoietic cell transplantation (alloHCT) is the only curative therapy for patients with high-risk hema...
Prednisolone and mycophenolate mofetil as first-line therapy in warm autoimmune hemolytic anemia: A prospective pilot study
Abstract Background: Warm autoimmune hemolytic anemia (wAIHA) is a rare immune disorder characterised by autoantibody-mediated destruction o...
CRISPR/Cas9-mediated CISH deletion and CD16a upregulation potentiates ADCC in NK cells against relapsed/refractory multiple myeloma
Abstract Background Relapsed/refractory multiple myeloma (RRMM) remains incurable for many patients despite recent advances in proteasome in...
In Vivo clonal dynamics of alloreactive CAR T cells reveal mechanisms limiting gvhd risk following allogeneic CAR T cell therapy
Abstract Introduction: Allogeneic CAR T cell therapy holds curative potential for patients with relapsed or refractory B-cell malignancies t...
Reproductive health in patients with primary immune thrombocytopenia (ITP) receiving rilzabrutinib: A subgroup analysis from the Phase 3 LUNA3 multicenter study
Abstract Introduction: ITP is an immune-mediated disorder characterized by low platelet counts with consequent increased bleeding risk. Addi...
Optimizing processes for adverse event management for bispecific antibodies for diffuse large b-cell lymphoma in community practice: Insights from a quality improvement initiative
Abstract Background In a previous quality improvement (QI) study designed to assess and address barriers to the adoption of novel therapies...
PARP1 inhibition sensitizes AML to CD123 CAR-NK cells via immunophenotypic remodeling
Abstract Background:Acute myeloid leukemia (AML) is an aggressive hematologic malignancy driven by leukemic stem cells (LSCs) with enhanced...
Real world outcomes of patients with CML-CP treated with tyrosine kinase inhibitors from the h. jean khoury cure CML consortium (HJKC3)
Abstract Background: The H. Jean Khoury Cure CML Consortium (HJKC3) was established with the overarching goals of improving the outcomes for...
Real-world safety and efficacy of aponermin and selinexor-based regimens in patients with multiple myeloma
Abstract Background: Treatment of relapsed/refractory multiple myeloma (RRMM) and frail newly diagnosed multiple myeloma (NDMM) patients rem...
An acquired immune-metabolic shift to common chemotherapy confers resistance to immunotherapies in relapsed, high-risk multiple myeloma
Abstract Introduction: The prognosis of multiple myeloma (MM) has improved significantly with the advent of targeted agents and immunotherapi...
Hematologic toxicities associated with PARP inhibitors: Real world pharmacovigilance updated study using faers database with era-trend evaluation and serious outcome modeling
Abstract Background: Poly ADP-ribose polymerase inhibitors (PARPi) have improved outcomes in cancers, particularly ovarian and breast cancer...
Umbilical cord blood microtransplantation improves the prognosis of patients with relapsed/refractory myeloid tumors who are not candidates for intensive therapy: Clinical efficacy and mechanism analysis
Abstract Objective: There is no unified standard for the optimal treatment of relapsed/refractory acute myeloid tumors (R/R MN). At present,...
Identification of two distinct human hematopoietic stem cell subsets and their age-dependent dynamics by single-cell multi-omics
Abstract Hematopoietic stem cells (HSCs) sustain lifelong blood production due to their unique capacities for self-renewal and multilineage...
Long-term HIV remission of a perinatally infected individual, following a hematopoietic cell transplantation from a CCR5Δ32 homozygous donor for multiple myeloma: The kyiv patient
Abstract Introduction: Antiretroviral therapy (ART) suppresses replication of HIV, though its inability to clear the latently infected reser...
The impact of viral pneumonia on hospital outcomes in sickle cell disease: A database review and analysis
Abstract Introduction: Sickle cell disease (SCD) is a subset of hereditary hemoglobinopathies characterized by chronic hemolysis, vaso-occlu...
Abatacept in combination with post-transplant cyclophosphamide and tacrolimus may improve survival and non-relapse mortality without increasing relapse risk after allogeneic stem cell transplantation
Abstract Introduction: Recent studies have shown the safety and feasibility of abatacept (ABA) addition to post-transpla...
Number of patients needed to treat to prevent one atrial fibrillation event with zanubrutinib versus ibrutinib and acalabrutinib in B-cell malignancies
Abstract Introduction Bruton tyrosine kinase inhibitors (BTKis) are used for the treatment of B-cell malignancies. Second generation (acalab...
Synergistic enhancement of γδ T cell cytotoxicity against tumor spheroids through B7H3 CAR and zoledronate sensitization
Abstract Despite significant progress in treating hematological malignancies with chimeric antigen receptor (CAR) T cell therapies, their ap...
Identifying and overcoming mechanisms of resistance to a VpreB1-directed antibody-drug conjugate in the treatment of B-cell acute lymphoblastic leukemia
Abstract Background: The treatment landscape of B-cell acute lymphoblastic leukemia (B-ALL) has been transformed by ther...
Lamin B1 mediates dynamic changes in heterochromatin and regulates erythropoiesis
Abstract Chromatin condensation is a crucial step in the maturation process of red blood cells. we explored the distribution changes of chro...
Single-center retrospective analysis of venetoclax-based triple-drug combination therapy for relapsed Acute Myeloid Leukemia post allogeneic hematopoietic stem cell transplantation.
Abstract Objective: To evaluate the efficacy and safety of venetoclax (VEN), cytarabine, and azacitidine (AZA) combination therapy in relaps...
Immune checkpoint inhibitor–associated cytopenias: A decade of real-world signal detection from faers (2014–2025)
Abstract Background: Immune checkpoint inhibitors (ICIs) targeting PD-1, PD-L1, and CTLA-4 have transformed cancer therapy. However, their e...
Characterization of two genetically distinct subtypes of C5 diffuse large B-cell lymphoma (DLBCL)
Abstract Diffuse large B-cell lymphoma (DLBCL) is a clinically and molecularly heterogeneous disease with two recognized transcriptional sub...
Non-GCB cell of origin leads to inferior outcomes in brazilian diffuse large B-cell lymphoma patients: Bra-DLBCL multicenter registry, retrospective study of over 500 patients
Abstract Introduction Despite the improvement in management of diffuse large B-cell lymphoma (DLBCL) in recent years, th...
An open-label, Phase I/II clinical trial of romaciclib (RVU120) as monotherapy and in combination with ruxolitinib in patients with intermediate or high-risk, primary or secondary myelofibrosis (POTAMI-61)
Abstract Background Myelofibrosis (MF) is associated with dysregulated JAK1/2 signaling. Ruxolitinib (RUX, JAK1/2 inhibitor) was the first t...