Blood
Articles in this Issue
Renal response of selinexor, bortezomib, pomalidomide, and dexamethasone in newly diagnosed multiple myeloma patients with renal impairment: A phase 2, prospective, multicenter study
Abstract Renal impairment (RI) is a common complication of multiple myeloma (MM), accounting for ~40% of newly diagnosed MM (NDMM), which as...
Abbreviated anticoagulation regimen with direct oral anticoagulants is safe and efficacious in the management of infection-associated cerebral sinovenous thrombosis in children
Abstract Introduction There has been a dramatic increase in the rate of venous thrombo-embolism (VTE) amongst hospitalized children in the U...
Liquid biopsy by analysis of circulating tumor cells, hormonal and inflammatory biomarkers in plasma cell neoplasms, at Fundación Santa Fe de Bogotá hospital
Abstract The detection of circulating tumor cells (CTC) is becoming increasingly important due to growing evidence demonstrating their progn...
Clonal evolution and therapeutic vulnerabilities in SETBP1-mutated leukemia: Insights from physiological mouse model and integrative functional screens
Abstract Somatic mutations in SET binding protein 1 (SETBP1), a putative chromatin regulator, occur in ~30% of high-risk myeloid malignancie...
Single-center experience with emicizumab in Chinese children under 3 years with severe Hemophilia A
Abstract Background: Prophylactic treatment is essential for children with severe hemophilia A to prevent bleeding episodes and long-term jo...
Total marrow irradiation-based, intensified reduced-intensity conditioning regimen for haploidentical hematopoietic cell transplantation with posttransplant cyclophosphamide: A prospective study
Abstract Introduction Post-transplant cyclophosphamide (PTCy) has nearly revolutionized the field of haploidentical hema...
Association of low annexin A2 levels with venous thromboembolism in sickle cell anemia: A potential biomarker
Abstract Introduction Sickle cell disease (SCD) is an inherited blood disorder that affects millions of individuals worldwide. It is referre...
Efficacy of a 14-day venetoclax regimen in combination with a hypomethylating agent for Acute Myeloid Leukemia: A single-center retrospective analysis
Abstract Background : Venetoclax in combination with a hypomethylating agent has become the current standard of care in elderly or unfit pat...
Absolute lymphocyte count is predictive of response to salvage therapies for post-CAR T failure
Abstract Introduction: Most patients with relapsed or refractory large B-cell lymphoma who undergo CD19-directed CAR T-c...
Recruitment strategies and enrollment for an ongoing virtually supervised prehabilitation exercise intervention in patients diagnosed with multiple myeloma scheduled to receive autologous stem cell transplant: Preliminary findings
Abstract Background: Exercise interventions remain understudied in the prehabilitation setting for patients with hematologic malignancies wi...
Efficacy of tgrx-678, a potent BCR::ABL1 allosteric inhibitor, in CML-CP and CML-AP patients harboring T315I mutation: Results from a phase 1 study
Abstract Background: TGRX-678 is a novel allosteric inhibitor of ABL kinases that specifically targets the Myristoyl Pocket (STAMP) of ABL....
Single-cell DNA profiling unveils clonal evolution and identifies mechanisms of therapeutic resistance and progression in monoclonal gammopathies
Abstract INTRODUCTION Monoclonal gammopathies –including MGUS, smoldering multiple myeloma (SMM), and multiple myeloma (MM)– are driven by c...
Protein levels of isocitrate dehydrogenase 1 and 2 are prognostic and independent of mutation status in acute myelogenous leukemia
Abstract INTRODUCTION: Mutations in the Isocitrate Dehydrogenase 1 and 2 (IDH1/2) occur in ~20% of Acute Myelogenous Leukemia (AML) cases an...
Post-induction minimal residual disease assessment by flow cytometry and molecular biology enables prognostic stratification of patients with NPM1-mutated Acute Myeloid Leukemia: A dataml registry study.
Abstract IntroductionMRD assessment in AML provides a quantitative approach to define a deeper remission status and refine the risk assessme...
Deep hematologic response to daratumumab without cardiac recovery in AL amyloidosis: A persistent dissociation in real-world practice
Abstract Background Daratumumab has transformed the management of AL amyloidosis by significantly improving hematologic response rates [1]....
Prognostic impact of persistent and treatment-emergent cytopenia in 879 myelofibrosis patients treated with ruxolitinib: The “RUX-MF” study
Abstract Introduction Cytopenia, such as anemia and thrombocytopenia, are associated with inferior overall survival (OS) in patients (pts) wi...
Efficacy and safety of zanubrutinib combined with reduced-dose bendamustine and Rituximab for eldly Mantle Cell Lymphoma: A retrospective analysis
Abstract BR regimen was a common treatment for elderly patients with mantle cell lymphoma, however, infection and treatment tolerability rem...
Therapy-related core binding factor Acute Myeloid Leukemia – a Study of the french acute leukemia intergroup
Abstract Introduction Therapy-related CBF-AMLs represent approximately 10% of all CBF-AMLs and are associated with poorer outcomes, partly d...
Preliminary analysis of a single-center study on chidamide combined with ICD regimen in bortezomib-exposed relapsed/refractory multiple myeloma patients
Abstract Background: The therapeutic challenge in relapsed/refractory multiple myeloma (RRMM) stems from high genomic instability, clonal he...
Haplo-identical transplantation in patients with myelofibrosis, a phase 2 prospective multicentric study
Abstract In higher risk myelofibrosis patients, the only treatment able to improve survival and cure the disease is allogeneic hematopoietic...
Peripheral immune checkpoints predict prognosis and reveal PD-1/treg/IL-10 crosstalk in B cell lymphoma
Abstract Background: B-cell lymphoma is a hematologic malignancy associated with B cell molecular pathways and immune microenvironment dysre...
Butyrate ameliorates Tet2-deficient clonal hematopoiesis phenotypes driven by high B12-induced gut dysbiosis.
Abstract Introduction: Recent studies have linked elevated vitamin B12 serum levels with the presence of clonal hematopoiesis (CH) and an in...
Red cell indices in adolescents with iron deficiency and heavy menstrual bleeding
Abstract Background: Iron deficiency (ID) and iron deficiency anemia (IDA) are common in adolescents with heavy menstrua...
Epigenetic dysregulation of the polycomb axis in Acute Myeloid Leukemia: Clinical and prognostic correlates
Abstract Background Epigenetic regulation of gene expression is a complex biological process. Polycomb Repressive Complex (PCR) 1 & 2 re...
VISTA contributes to disease progression in high-risk myelodysplastic syndrome
Abstract Myelodysplastic syndrome (MDS) is a hematologic disorder characterized by ineffective hematopoiesis and cytopenias, with a risk of...