Blood
Articles in this Issue
Non-infectious fever predicts poor survival in azacitidine-treated high-risk, but not low-risk, myelodysplastic syndromes：a multicenter real-world cohort study (KOTOSG)
Abstract Background Growing evidence indicates that dysregulated inflammation—marked by specific genetic abnormalities and elevated inflammat...
DNMT3A-driven clonal hematopoiesis permits colitis-associated tumorigenesis by promoting innate immune tolerance
Abstract Clonal hematopoiesis (CH), defined as an expanded hematopoietic stem cell (HSC) clone with somatic mutations in the absence of bloo...
Clinicopathologic and treatment influences on diffuse large B-cell lymphoma survival: A 10-year safety-net hospital experience
Abstract Background: Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous malignancy with outcomes influenced by clinicopathologic facto...
Determinants of early mortality following induction chemotherapy in Acute Myeloid Leukemia: Experience from a comprehensive cancer center in Latin America
Abstract Background: Survival after induction chemotherapy in patients with acute myeloid leukemia (AML) is limited by both treatment-relate...
Son haploinsufficiency in hematopoietic cells disrupts the crosstalk between splicing fidelity and chromatin accessibility, impairing lymphoid lineage commitment
Abstract Introduction: Hematopoietic lineage specification and differentiation rely on precise gene regulation, integrating transcription fac...
Genetic risk stratification in adults with AML receiving venetoclax-based intensive therapy: A real-world study
Abstract Venetoclax (VEN) has shown promising efficacy when combined with intensive chemotherapy regimens—such as FLAG-IDA (DiNardo et al. 2...
Abnormal adhesion of particular hematopoietic stem and progenitor cell subpopulations in the bone marrow, driven by aberrant interaction between VCAM-1 and VLA-4, ultimately contributes to leukemogenesis
Abstract Introduction: The interplay between Vascular Cell Adhesion Molecule-1 (VCAM-1) and Very Late Antigen-4 (VLA-4, α4β1 integrin) is es...
Prophylaxis CTLA4-ig reduces anti-AAV neutralizing antibodies in AAV gene therapy for hemophilia
Abstract Objective: This study aimed to investigate the inhibitory effect of CTLA4-Ig on anti-AAV neutralizing antibody (Nab) development af...
Beyond clonal hematopoiesis of indeterminate potential: Understanding how the trisomy 21 context promotes TET2 mutations
Abstract Clonal hematopoiesis of indeterminate potential (CHIP) is the observation in the peripheral blood of a somatic mutation in a gene a...
Impact of thiotepa dose in haploidentical allogeneic stem cell transplantation with thiotepa-busulfan-fludarabine conditioning for Acute Myeloid Leukemia in remission: A retrospective analysis of the EBMT acute leukemia working party
Abstract Background - Haploidentical hematopoietic stem cell transplantation (haplo-HSCT) has become an increasingly adopted curative strate...
Real-world utilization patterns of bone-modifying agents for multiple myeloma in the era of novel therapies
Abstract Background Little is known about the utilization patterns of bone modifying agents (BMA) among patients with newly diagnosed multip...
Clinical impact of atrial fibrillation on hospitalized patients with myeloproliferative neoplasms: A nationwide analysis
Abstract Background: Patients with myeloproliferative neoplasms (MPNs), including essential thrombocythemia (ET), polycythemia vera (PV), an...
The prevalence of inborn errors of immunity (IEI)-related gene germline variants and its prognostic impact in Chinese pediatric patients with lymphoma
Abstract Introduction: Patients with inborn errors of immunity (IEI) have a higher risk of developing lymphoma than the general population....
Race matters: Cytopenia trajectories after chimeric antigen receptor T- cell therapy in a single-center study
Abstract CAR T-cell therapy has changed the landscape of relapsed-refractory non-Hodgkin lymphoma and multiple myeloma (MM). While cytokine...
The CHD1L protein regulates cell activation by controlling lipid-related metabolism in B cells
Abstract Clinical observation has found that the increase of B-cell infiltration (TIL-B) and the formation of mature tertiary lymphoid struc...
Isatuximab for the treatment of monoclonal gammopathy of renal significance (MGRS): Results from a prospective multicenter Phase 2 trial
Abstract Background: MGRS encompasses a group of heterogeneous disorders characterized by renal dysfunction caused by the interaction with a...
A multicentre UK snapshot audit of symptom burden in patients with indolent systemic mastocytosis utilising the ISM-SAF ©
Abstract Background: Indolent systemic mastocytosis (ISM) is a rare clonal haematological neoplasm driven by KIT D816V mutation in 95% of ca...
Rewiring lipid metabolism: A novel approach to overcome drug resistance in multiple myeloma
Abstract Despite significant therapeutic advancements in multiple myeloma (MM) treatment, which have improved patient outcomes and extended...
Oral decitabine-cedazuridine versus parenteral hypomethylating agents in treatment-Naïve TP53-mutated Myelodysplastic Syndromes
Abstract Introduction TP53-mutated myelodysplastic syndrome (mTP53-MDS) is characterized by genomic instability, resistance to standard ther...
Pre-manufacturing CD8+ central-memory type 2 T cells predict axicabtagene ciloleucel failure in large B-cell lymphoma
Abstract Introduction Axicabtagene Ciloleucel (Axi-Cel), a CD28-based anti-CD19 CAR T-cell therapy, induces remission in approximately 50% o...
Experience with minor surgeries in people with hemophilia A or B with and without inhibitors receiving fitusiran
Abstract Introduction While the number of approved non-factor hemophilia therapies is increasing, data regarding the perioperative managemen...
Allogeneic hematopoietic cell transplantation in dyskeratosis congenita: Short and long- term outcome of 183 consecutive patients transplanted at EBMT centers
Abstract Introduction Dyskeratosis congenita (DKC) is a rare telomere disorder causing multi-organ dysfunction and bone marrow failure, with...
Outcomes of autologous hematopoietic stem cell transplantation in nodular lymphocyte-predominant Hodgkin lymphoma: A registry-based study from the EBMT-LWP
Abstract INTRODUCTION Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare subtype of Hodgkin lymphoma (HL), accounting for appr...
Hematopoietic JAK2V617F mutation increases susceptibility to atrial fibrillation via NLRP3 inflammasome activation in macrophages
Abstract Clonal hematopoiesis of indeterminate potential (CHIP), an age-related phenomenon, elevates the risk of hematological malignancies...
Safety and efficacy of aponermin-based chemotherapy as bridging therapy before CAR-T cell treatment in relapsed/refractory multiple myeloma
Abstract Introduction Chimeric antigen receptor (CAR) T-cell therapy represents a breakthrough in the treatment of relapsed or refractory (R...