Blood
Articles in this Issue
Center effect on large B-cell lymphoma outcome in frontline prospective Phase II and III trials : A lysa study
Abstract Introduction. A growing body of evidence from both solid and hematologic malignancies has demonstrated a significant center effect...
Icans mitigation in high-risk elderly patients treated with CD28 co-stimulatory anti-CD19 CAR-T cells using a standardization protocol – a pilot study
Abstract Background CAR-T therapy has transformed the treatment of relapsed or refractory LBCL, with CD28-based products offering rapid resp...
Evolution of care and outcomes of kidney transplantation in plasma cell dyscrasias: A single center experience
Abstract Background: Historically, managing kidney failure from Plasma Cell Dyscrasias (PCDs) was limited to dialysis, as kidney transplanta...
CARDINAL: A Phase 1 study of TERN-701, a novel investigational allosteric BCR::ABL1 inhibitor for patients with previously treated CML
Abstract Introduction: While outcomes for patients (pts) with chronic phase chronic myeloid leukemia (CML-CP) have substantially improved wi...
Subsequent primary malignancies after CAR-T therapy: A study from the US multiple myeloma immunotherapy consortium
Abstract Introduction: The CAR-T therapies ide-cel and cilta-cel are approved for patients (pts) with relapsed/refractory multiple myeloma (...
Unraveling the mysteries of platelet fatigue in cold storage: Calcium release dynamics and energy metabolism as therapeutic targets.
Abstract Background: Cold storage improves platelet shelf-life due in part to suppressed metabolism, but platelet function still rapidly dec...
The dysregulated lipid metabolism is associated with CD8+ T cell senescence in HIV-associated diffuse large B cell lymphoma
Abstract Backgrounds Our previous study revealed that HIV+ DLBCL patients exhibit senescent-like dysfunction in CD8+ T cells. While it is kn...
Targeting immunoproteasome-dependent β-catenin degradation as a therapeutic strategy in Relapsed/Refractory acute lymphoblastic leukemia
Abstract Background and Significance: As central component of canonical WNT-signaling, β-catenin functions as oncogenic driver that promotes...
Impact of treatment facility type on survival outcomes in mantle cell lymphoma: A 20-year NCDB analysis
Abstract Background: Mantle Cell Lymphoma (MCL) is a rare subtype of B-cell non-Hodgkin lymphoma characterized by hetero...
Global, regional, and national burden of G6PD deficiency: A three-decade analysis across 204 countries
Abstract Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is one of the most common enzymatic disorders g...
Hemoglobin S beta thalessemia plus: Clinical analysis from the Georgia comprehensive sickle cell center at grady memorial hospital, Atlanta, Georgia.
Abstract Introduction: Hemoglobin (Hb) S beta thalassemia plus (β+) is a variant of sickle cell disease (SCD) characterized by inheritance o...
Targeting SP1 condensates suppresses HNRNPUL1 via super-enhancers to attenuate Acute Myeloid Leukemia progression
Abstract Acute myeloid leukemia (AML) is a genetically heterogeneous myeloid malignancy that accounts for approximately 20% of pediatric leu...
Real-world chronic lymphocytic leukemia/small lymphocytic lymphoma treatment patterns at Florida cancer specialists & research institute among patients receiving zanubrutinib immediately following prior BTKi therapy
Abstract Introduction Zanubrutinib, a second-generation Bruton tyrosine kinase inhibitor (BTKi), is approved for the treatment of previously...
Use of emapalumab is associated with rapid and sustained benefits in primary HLH subgroups, including CNS involvement and previously untreated patients: Pooled analysis of prospective trials NI-0501-04, NI-0501-05 and NI-0501-09
Abstract Introduction: To provide additional insights into treatment with emapalumab in primary hemophagocytic lymphohistiocytosis (pHLH), w...
Chronic pulmonary LPS exposure in cystic fibrosis drives maladaptive pro-inflammatory hematopoietic stem and progenitor cells
Abstract Background: Persistent lung inflammation characterizes cystic fibrosis (CF), mainly driven by myeloid cells (neutrophils and monocyt...
Second primary malignancies in multiple myeloma: Incidence, survival and prognostic factors from a large single-center observational study
Abstract Introduction: The risk of second primary malignancies (SPMs) has emerged as a growing clinical concern in patients with multiple my...
Therapeutic outcomes of glofitamab-based regimens in Chinese patients with Relapsed/Refractory B-cell lymphoma: A single-center retrospective real-world study
Abstract Background: Glofitamab has demonstrated promising efficacy in relapsed/refractory (R/R) Diffuse large B-cell lymphoma (DLBCL) in gl...
Single-cell multiomics reveals molecular identities and clonal dynamics of MRD progression in Myelodysplastic Syndromes after stem cell transplant
Abstract Background: Stem cell transplantation (SCT) is the only curative option for higher-risk myelodysplastic syndromes (MDS). Neverthele...
Molecular and cytogenetic landscape of black patients with myelodysplastic syndrome in the veterans health affairs
Abstract Introduction: Myelodysplastic syndromes (MDS) are clonal hematopoietic disorders characterized by ineffective hematopoiesis, cytope...
Development and clinical evaluation of a cost-effective method with capillary electrophoresis sequencer-based fragment analysis assay panel for genetic classification and risk stratification in de novo AML
Abstract Background In patients diagnosed with AML, the implementation of leukemia gene testing in accordance with the ELN 2022 guidelines i...
Anakinra for hemophagocytic lymphohistiocytosis: A real-world, multicenter retrospective study on efficacy, safety, and response durability
Abstract Background: Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening syndrome of excessive inflammation driven by immune dysr...
EP31670, a dual-BET + p300 inhibitor, demonstrates pre-clinical efficacy, including in combination with JAK inhibition, in the hMPLW515L adoptive transfer model of myelofibrosis (MF)
Abstract Background: Bromodomain and Extra-Terminal (BET) motif inhibitor therapy, alone or in combination with JAK inhibition (JAKi), is eme...
Gene therapy in three classical hematological disorders – is social media making a difference?
Abstract Gentically driven classical hematological disorders have variable prevelance in the general population, sickle cell disease (SCD) b...
Genomic characteristics of diffuse large B-cell lymphoma associated with Wiskott-Aldrich syndrome
Abstract Introduction Wiskott-Aldrich syndrome (WAS) is a rare X-linked inborn error of immunity (IEI) characterized by thrombocytopenia, ec...
Geriatric hematologic care in Latin America: Results from a regional survey of hematology centers
Abstract Background Older adults with cancer often face additional challenges in disease management. Limited awareness among medical profess...