Blood
Articles in this Issue
Multisystem flare of systemic lupus erythematosus presenting with severe warm autoimmune hemolytic anemia: A diagnostic and transfusion challenge
Abstract Introduction: Warm autoimmune hemolytic anemia (wAIHA) is a potentially life-threatening complication of systemic lupus erythematos...
Adolescent cardiovascular-kidney-metabolic health and estrogen exposure: A cross-sex, gender-inclusive cohort analysis
Abstract While emerging evidence demonstrate the risk of cardiovascular-kidney-metabolic (CKM) syndrome in aging population, these risks rem...
Pulmonary Embolism–Attributable mortality among patients with breast cancer in the United States, 1999-2021
Abstract Introduction: Pulmonary embolism (PE) remains a leading preventable cause of morbidity and mortality in cancer patients. Over the l...
Safety and efficacy of IL-6 knockdown anti-CD19 CAR-T cells (ssCART-19) in the treatment of primary/secondary central nervous system lymphoma
Abstract Background Although several CD19-targeting CAR-T cell therapies have been approved for the treatment of relapsed/refractory B-cell...
Efficacy and safety of spleen tyrosine kinase inhibitors in chronic immune thrombocytopenic purpura: A meta-analysis of randomized controlled trials
Abstract Background: Chronic immune thrombocytopenic purpura (ITP) is an autoimmune disorder characterized by persistent low platelet counts...
Pharmacokinetic-pharmacodynamic modelling of von willebrand factor/factor VIII prophylaxis in von willebrand disease
Abstract Background: Long-term prophylaxis with a von Willebrand factor (VWF) concentrate is recommended in patients wit...
The simplified age and stage (SAS) score improves OS prediction after allogeneic stem cell transplantation
Abstract Background Allogeneic hematopoietic cell transplantation (allo-HCT) is a potentially curative treatment for acute leukemia and myel...
MC-MIL net: A multi-cascaded dual-stream multiple instance learning diagnostic framework for castleman disease.
Abstract Introduction: Castleman disease (CD) is a rare lymphoproliferative disorder with complex pathological features, leading to challeng...
A compact, anti-CD38 T-cell engager with a short half-life demonstrates superior anti-myeloma activity over traditional bispecific antibodies
Abstract Introduction: Daratumumab (Dara) is a highly effective monoclonal antibody targeting CD38, a receptor that is overexpressed on mult...
Clinical validation of a point-of-care device versus standard monitoring of vital signs in patients undergoing hematopoietic cell transplantation
Abstract Introduction: Alterations in vital signs often precede clinical deterioration, allowing for timely intervention. This is particular...
Optimized treatment for pediatric patients with low-risk Acute Myeloid Leukemia: A report from the Children's oncology group study AAML1831
Abstract Introduction: Prior comparison of low risk (LR) pediatric acute myeloid leukemia (AML) patients enrolled on Children's Oncology Gro...
Overview of treatment advances with complement inhibitors in patients with paroxysmal nocturnal hemoglobinuria
Abstract Introduction: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired hematologic disorder that leads to lifelong risk for th...
Ex vivo treatment by mitapivat, an allosteric pyruvate kinase activator, reduced oxidative stress to support terminal erythropoiesis of non-transfusion dependent thalassemia patients due to β-thalassemia/hb e disease
Abstract Introduction: Ineffective erythropoiesis is one of the pathophysiological characteristics in the bone marrow of severely anemic pat...
The impact of extracorporeal membrane oxygenation on survival in critically ill adults with sickle cell acute chest syndrome: A national retrospective cohort study using inverse probability of treatment weighting
Abstract Introduction: Acute Chest Syndrome (ACS), a severe complication of Sickle Cell Disease (SCD) driven by a cascade of vaso-occlusion,...
Pre-transplant nutritional status and hospitalization risk in outpatient hematopoietic stem cell transplantation: A prospective study using the patient-generated subjective global assessment
Abstract Background Hematopoietic stem cell transplantation (HSCT) is a complex process that can impair nutritional stat...
Resistance to imatinib of leukemia growth in non-marrow organs and eradication by dasatinib: Published cases and gene clues
Abstract Introduction Imatinib (IMAT) made possible complete marrow remissions of CML beginning in 1998. By 2001, relaps...
The safety and efficacy of belumosudil and ruxolitinib combination in ruxolitinib refractory chronic graft-versus-host disease
Abstract Background Chronic graft-versus-host disease (cGVHD) remains a leading cause of non-relapse mortality post-allogeneic hematopoietic...
Ruxolitinib combined with decitabine-intensified modified busulfan/cyclophosphamide conditioning regimen reduces relapse after allogeneic hematopoietic stem cell transplantation in Acute Myeloid Leukemia
Abstract Allogeneic hematopoietic stem cell transplantation is the only radical treatment for high-risk acute myeloid leukemia (AML), but th...
Results from the first clinical trial of the selective GlyT1 inhibitor bitopertin for steroid-refractory Diamond-Blackfan Anemia (NCT05828108)
Abstract Background: Diamond-Blackfan Anemia (DBA) is an inherited macrocytic anemia. Despite an initial 80% steroid response rate, approxim...
Association of reproductive factors and exogenous hormone use with the risk of multiple myeloma in men and women
Abstract Background: Multiple Myeloma (MM) is a plasma cell malignancy with known risk factors that include increasing age, male sex, obesit...
ClonoSEQ MRD negativity at day 90 is a strong predictor for progression-free and overall survival after BCMA-directed CAR T-cell therapy for relapsed multiple myeloma.
Abstract Introduction: Next-generation sequencing (NGS)-based minimal residual disease (MRD) assessments are increasingly utilized in multip...
Thrombosis, bleeding, and progression in JAK2 V617F clonal hematopoiesis
Abstract BACKGROUND: JAK2 V617F mutations occur frequently in patients with myeloproliferative neoplasms (MPNs) and are associated with incre...
A phase I study of the combination of ruxolitinib and the ERK1/2 inhibitor ulixertinib in previously treated myelofibrosis patients.
Abstract Background: Myelofibrosis (MF) is a clonal hematopoietic stem cell (HSC) malignancycharacterized by aberrant activation of the JAK-...
Persistent hyponatremia as a distinctive feature of HHV-6B encephalitis in pediatric hematopoietic stem cell transplant recipients: A case series
Abstract Background: Electrolyte imbalances are a common complication in the context of transplantation, generally presenting as mild and re...
TP53 activation by the natural quassinoid brusatol enhances venetoclax efficacy and overcomes resistance in myeloid leukemias
Abstract Introduction Based on the encouraging results from the VIALE-A and VIALE-C trials, venetoclax in combination with azacitidine or cy...