Blood
Articles in this Issue
Norad long noncoding RNA, a decoy for pumilio RNA-binding proteins, elevates fetal hemoglobin levels
Abstract NORAD long noncoding RNA (Noncoding RNA activated by DNA Damage) is a highly conserved, abundant, and widely expressed long non-cod...
Clinical and genomic impact of TP53 and BCL2 co-alterations in diffuse large B-cell lymphoma
Abstract Background Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease with both clinical and genetic variability. Mutations i...
Application of dorsal skin fold chamber microvascular thrombosis model in JAK2V617F mice
Abstract Individuals with JAK2V617F+ myeloproliferative neoplasm (MPN) exhibit symptoms of microvascular stasis that include headaches, itch...
Challenge to redifferentiate b lymphocyte-derived ips cells carrying t(11;14) with or without p53 back into b lymphocytes
Abstract Background: We previously attempted to prove the existence of abnormal B cells, which are thought to be myeloma-initiating cells th...
Outcomes in older adults (≥60 Years) with normal karyotype acute myeloid leukemia treated with intensive vs. lower-intensity chemotherapy: Path to a molecularly guided upfront treatment approach
Abstract Background: Hypomethylating agents (HMA) combined with venetoclax (VEN) are the current standard-of-care lower-intensity therapy (L...
Dynamic ΔEASIX score is a robust predictor of survival and relapse after allogeneic hematopoietic cell transplantation in acute leukemia
Abstract Allogeneic hematopoietic cell transplantation (allo-HCT) remains a curative therapy for acute leukemia in transplant-eligible patie...
KPNA2 enhances autophagy through activation of the non-canonical NF-κB signaling pathway, thereby promoting the induction of bortezomib resistance in multiple myeloma
Abstract KPNA2 enhances autophagy through activation of the non-canonical NF-κB signaling pathway, thereby promoting the induction of bortez...
AI-driven platform voyager identifies a novel poison exon and splicing modulator to target specific degradation of STAT1
Abstract Hematopoietic cells orchestrate waves of transcriptomic networks to guide essential processes such as differentiation, growth or re...
Optimizing elritercept benefit-risk profile by response-based adaptive dosing in patients with low-risk Myelodysplastic Syndromes (LR-MDS)
Abstract Background: Elritercept, an investigational, modified activin receptor type IIA/IgG1 fusion protein designed to selectively bind an...
Single-cell multiomic dissection of human hematopoietic stem cells reveals novel transcriptional fingerprints and regulatory programs in bone marrow and mobilized peripheral blood
Abstract Hematopoietic stem and progenitor cells (HSPCs) are central to therapeutic strategies such as bone marrow transplantation and gene...
Safety and feasibility of 0.6 mg/kg every 4 weeks dosing of axatilimab in patients treated in the AGAVE-201 study
Abstract Introduction: Axatilimab is an anti–colony-stimulating factor 1 receptor (CSF-1R) monoclonal antibody that targets monocytes and ma...
Efficacy and safety results of linperlisib in adult patients with primary immune thrombocytopenia (ITP)
Abstract Introduction: Primary immune thrombocytopenia (ITP) is an acquired autoimmune hemorrhagic disease characterized by continuous throm...
Global proteomic profiling of tgrx-3247，a heterobifunctional degrader for the treatment of BCR::ABL1-driven chronic myeloid leukemia
Abstract Tyrosine kinase inhibitors (TKIs) and agents Specifically Targeting ABL1 Myristoyl Pocket (STAMP) are currently the standard of car...
Final results of a multi-center phase 2 trial of isatuximab-lenalidomide in patients with high risk smoldering multiple myeloma (HRSMM)
Abstract Background: In analyses conducted by the Spanish Myeloma Group, Mayo Clinic and International Myeloma Working Group, patients with...
Real-world analysis of axicabtagene ciloleucel (axi-cel) as consolidation therapy following first-line treatment in B-cell lymphoma with high-risk factors
Abstract Background: Approximately 60% of patients with large B-cell lymphoma (LBCL) achieve cure with standard first-line (1L) therapies, s...
Clinical activity, tolerability, and pharmacodynamics of ulviprubart in patients with T-cell large granular lymphocytic leukemia: Interim Results of A phase 1 trial
Abstract Background T-cell large granular lymphocytic leukemia (T-LGLL) is a rare cause of anemia and neutropenia characterized by clonal ex...
Targeting HMGA1-driven leukemic transformation in myeloproliferative neoplasms with pacritinib
Abstract Background: The transformation of myeloproliferative neoplasms (MPNs) to secondary acute myeloid leukemia (sAML) is a lethal event w...
Daratumumab for immune-mediated thrombotic thrombocytopenic purpura (iTTP): Results from the international, multicenter darttp study
Abstract Background and Methods: approximately 15% of patients with iTTP fail to achieve a sustained ADAMTS13 remission with rituximab or ot...
Orelabrutinib in the treatment of pure red cell aplasia after allogeneic hematopoietic stem cell transplantation
Abstract Background:Allogeneic hematopoietic stem cell transplantation (allo-HSCT) currently represents the only curative treatment for pati...
ST2 as a biomarker of cytokine release syndrome following CD19-targeted chimeric antigen receptor T-cell therapy
Abstract Introduction Axicabtagene ciloleucel (axi-cel) is a CD19-targeted chimeric antigen receptor (CAR) T-cell therapy with curative pote...
Identifying fusions in AML/MDS: An experience from first 400 patients enrolled into myelomatch
Abstract Introduction: MyeloMATCH (mM), is an National Cancer Institute (NCI)-sponsored precision medicine initiative for newly diagnosed AM...
Trends in coagulation defects related mortality in adults in the United States - a retrospective analysis from 1999-2023.
Abstract Introduction: Coagulation disorders represent a heterogeneous group of conditions characterized by impaired hem...
Oral–Gut microbiome coalescence and ecosystem fragility promote drug-resistant colonization and infection in relapsed/refractory leukemia
Abstract The host microbiome is not a passive bystander but an active determinant in acute leukemia (AL) treatment outcomes. Our dual-cohort...
Molecular gene panel analysis in aplastic anaemia: Diagnostic utility and clinical implications
Abstract Background Aplastic anaemia (AA) is an acquired immune-mediated bone marrow failure and pathogenic somatic variants are rarely pres...
R-propranolol Promotes lipid synthesis via a novel, non-adrenergic pathway to treat sickle cell cardiomyopathy
Abstract Background/Hypothesis: Sickle cell cardiomyopathy (SCC) is characterized by diastolic dysfunction, heart failure, and ventricular a...