Blood
Articles in this Issue
Unraveling progression predictors in prefibrotic myelofibrosis: A 2,000-patient systematic review and meta-analysis
Abstract Background: Prefibrotic primary myelofibrosis (pre-PMF) is a distinct clinical entity within the myeloproliferative neoplasms (MPNs...
A new pathogenic variant red cell membrane defect resulting in chronic hemolytic anemia
Abstract Hereditary Pyropoikilocytosis (HPP) is a red blood cell membrane defect characterized by severe and symptomatic hemolytic anemia. T...
Elevated risk of non-neoplastic mortality among adolescent and young adult patients with low-grade B-cell lymphoma
Abstract Background Adolescent and young adult (AYA) patients with low-grade B-cell lymphoma/leukemia (LoGL) typically have favorable cancer-...
The relationship of social support and psychosocial complexity with chimeric antigen receptor T-cell therapy outcomes
Abstract Background: Chimeric antigen receptor T-cell therapy (CAR-T) is a transformative therapy for relapsed/refractory hematologic malign...
Inpatient vs outpatient treatment management with teclistamab in relapsed and refractory multiple myeloma: A cost and healthcare resource utilization analysis
Abstract Introduction: Teclistamab is a first-in-class bispecific antibody targeting CD3 on T-cells and B-cell maturation antigen (BCMA) on...
Real‑world experience with anti‑TFPI agent (Marstacimab) in severe and non‑severe hemophilia: First reported successful use in a female with non-severe hemophilia b
Abstract We report results of the first real world study evaluating outcomes in people with severe and non-severe hemophilia (SH, NSH), incl...
Consensus on optimal use of fixed-duration BTK inhibitor and venetoclax therapy in CLL: A delphi study comparing human expertise and AI methodologies
Abstract Background: In the context of fixed-duration (FD) Bruton's tyrosine kinase inhibitor (BTKi) and B-Cell Lymphoma 2 inhibitor (BCL2i)...
Deciphering the cellular hierarchy of multiple myeloma uncovers a therapeutically exploitable EP300/TBX2 axis in LILRB4+ myeloma-initiating cells
Abstract Background: In contrast to leukemia, where the cancer stem cell model has clearly explained tumor hierarchies, multiple myeloma (MM...
Large B-cell lymphoma after CD19-CAR-T failure: Updated real-world outcomes, prognostic factors, and prediction models
Abstract Background While CD19-CAR-T cell therapy has revolutionized treatment for relapsed/refractory (R/R) large B-cell lymphoma (LBCL), a...
Improved Survival outcomes with allo-HSCT in NUP214::ABL1-Positive Acute leukemia: A pooled analysis and single-center experience
Abstract Introduction The NUP214::ABL1 fusion gene, resulting from the fusion of nucleoporin NUP214 and the tyrosine kinase ABL1, harbors ki...
Clinical characteristics and outcomes of cerebral venous sinus thrombosis in hematologic malignancy patients pre- and post-hematopoietic stem cell transplantation: A single-center retrospective study in China
Abstract Introduction: Cerebral venous sinus thrombosis (CVST) is a rare but life-threatening complication in patients w...
INCB057643, a bromodomain and extra-terminal protein inhibitor, in combination with ruxolitinib in patients with myelofibrosis: A phase 1 study of safety and efficacy
Abstract Background: The pathophysiology of myelofibrosis (MF) and other hematologic malignancies is modulated by the epigenetic reader brom...
Remote multi-vital sign monitoring allows earlier detection of cytokine release syndrome after bispecific T cell engager and chimeric antigen receptor T cell therapies
Abstract Introduction: Cytokine release syndrome (CRS) is a systemic inflammatory condition seen in 50-80% of patients after bispecific T ce...
Second-generation tyrosine kinase inhibitors vs imatinib in adult ph+ ALL: Target-trial emulation using a propensity-matched multinational cohort
Abstract Background: Philadelphia chromosome–positive acute lymphoblastic leukemia (Ph + ALL) accounts for 20–30 % of adult ALL and carries...
M6A-driven control of T cell fitness via lrpprc defines a novel regulatory axis to enhance adoptive cell therapy
Abstract Adoptive cellular therapies (ACT) including chimeric antigen receptor (CAR)-T cells have transformed the treatment landscape for pa...
Use of an oncology informatics knowledgebase to improve influenza vaccination rate in pediatric oncology patients
Abstract Introduction: It is well known that children with cancer are at an increased risk of severe influenza infections due to immunosuppr...
Overall response rates and progression free survival rates of bispecific antibodies vs CAR-T in the treatment of extramedullary disease and high-risk cytogenetics in relapsed multiple myeloma: A systematic review and meta-analysis
Abstract Background: Bispecific antibodies (BsAb) and Chimeric antigen receptor T-cell therapy (CAR-T) have significantly transformed treatm...
High sensitivity mass spectrometry for multiple myeloma monitoring using microsampling: A patient-centered approach
Abstract Background: Microsampling presents a minimally invasive alternative to venipuncture, offering potential improvements in the routine...
A collective non-mutational transition governs the development of chronic myeloid leukemia
Abstract Introduction: The field of carcinogenesis has been dominated by the concept that cancer is caused by the accumulation of genetic mu...
Thymic dysfunction promotes the emergence of pathogenic peripheral CD4⁺CD8⁺ T cells and induces tissue injury in acute gvhd
Abstract Acute graft-versus-host disease (aGVHD) is one of the most severe complications following allogeneic hematopoietic stem cell transp...
Venetoclax enhances T cell fitness and CAR T-cell manufacturing potential in chronic lymphocytic leukemia (CLL)
Abstract IntroductionChronic lymphocytic leukemia (CLL) is marked by profound immune dysregulation, which compromises both the numerical and...
GATA-3 identifies a distinct subset of T-cell prolymphocytic leukemia (T-PLL) and is associated with CCR4 expression
Abstract Background: T-PLL is a rare mature T-cell malignancy. Despite improved understanding of disease pathogenesis, outcomes remain poor....
Antiviral efficacy of EBV and CMV bispecific cytotoxic t lymphocytes following allogeneic hematopoietic stem cell transplantation
Abstract Purpose: To improve the cure rate of patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT), it is cruc...
Nationwide and regional trends, outcomes, and cost of systemic thrombolysis,standard catheter-directed thrombolysis, and ultrasound-assisted thrombolysisfor pulmonary embolism
Abstract Background: Pulmonary embolism (PE) is still a leading cause of morbidity and mortality in the United States (U...
The real-world safety and efficacy of BCMA-directed chimeric antigen receptor T-cell therapy in systemic AL amyloidosis
Abstract Introduction: Achieving rapid and deep hematological responses is essential for improving organ function and reducing early mortali...