Blood
Articles in this Issue
Enhancing real-world data (RWD) quality in oncology: Implementation of the qcard initiative in a large US oncology electronic health record (EHR)-derived database for research and regulatory decision-making
Abstract BACKGROUND: The Oncology Quality, Characterization, and Assessment of Real-world Data (QCARD) Initiative, led b...
A laser-based nanoparticle platform to enhance T cell–Mediated immunity without direct tumor access
Abstract Introduction: T cell-based therapies have revolutionized cancer treatment. Chimeric antigen receptor (CAR) T cell therapy has trans...
CD84-CD3 bispecific antibody achieves potent anti-leukemic activity with favorable safety profile in Acute Myeloid Leukemia
Abstract Title CD84-CD3 Bispecific Antibody Achieves Potent Anti-Leukemic Activity with Favorable Safety Profile in Acute Myeloid Leukemia...
Emergency department presentation is an independent driver of mortality, complications, and disparities in Acute Myeloid Leukemia: A national propensity-matched Study
Abstract Background Acute myeloid leukemia (AML) is an aggressive malignancy, so early diagnosis and timely therapy initiation are critical...
A pre-NGS screening strategy to identify populations with high-risk clonal hematopoiesis
Abstract Background: Myeloid neoplasms (MN) often originate in the bone marrow as premalignant clonal hematopoiesis (CH), the age-related ex...
NEO-201-based CAR NK cells as a novel immunotherapeutic approach to target truncated core 1 O-glycans in AML
Abstract Introduction: Despite therapeutic advances, acute myeloid leukemia (AML) continues to have poor long-term outcomes, particularly in...
TCR-T cells targeting a public neoantigen produced by the SF3B1 K700E mutation kill SF3B1-mutant AML/MDS
Abstract Myelodysplastic syndrome (MDS) is a life-threatening disease in which malignant bone marrow cells fail to differentiate, resulting...
ETNK1 mutations define a distinct subset of myeloid neoplasms with unique cytogenetic and molecular features
Abstract Background: Mutations in ethanolamine kinase-1 (ETNK1) have been identified in a wide range of myeloid neoplasms (MN), but their cli...
Proteomic study of extracellular vesicles reveals novel biomarkers for pathogenesis of immune thrombotic thrombocytopenic purpura
Abstract Background: Immune thrombotic thrombocytopenic purpura (iTTP) is a potentially fatal blood disorder, resulting from autoantibodies...
ASXL1 and NOTCH1 mutations independently predict TKI treatment failure in chronic myeloid leukemia
Abstract Background: While tyrosine kinase inhibitors (TKIs) have improved outcomes in chronic myeloid leukemia (CML), a subset of patients...
Inhibition of CPT1A reverses AML1-ETO-induced differentiation blockage by activating BCL-2/MYC signaling and metabolic reprogramming
Abstract Objectives: Recent studies have increasingly highlighted the pivotal role of fatty acid metabolism in regulating hematopoietic stem...
Transition to IRD maintenance after DRD induction significantly deepens response in transplant-ineligible NDMM: A prospective multicenter study
Abstract Background: The DRd regimen (daratumumab/lenalidomide/dexamethasone) has become a cornerstone of therapy for newly diagnosed multipl...
Pembrolizumab and pralatrexate for relapsed or refractory peripheral T-cell lymphomas
Abstract Background T-cell lymphomas (TCL) have limited treatment options and poor prognosis, representing an unmet medi...
Trial in progress: A study of roginolisib in combination with ruxolitinib in patients with myelofibrosis who are unresponsive to JAK inhibitors (HEMA-MED)
Abstract Background and Significance. Inhibition of both the Phosphoinositide 3-kinase (PI3K) pathway and Janus kinase (JAK) signalling leads...
Updated efficacy and safety results of JNJ-5322, a novel, next-generation BCMA×GPRC5D×CD3 trispecific antibody, in patients with Relapsed/Refractory multiple myeloma
Abstract Introduction: JNJ-5322 is a novel, next-generation trispecific antibody with capabilities to target dual myeloma antigens with a sin...
Novel indirubin-3-monoxime derivative I3MV-8b enhances anti-CD38 monoclonal antibody efficacy in multiple myeloma through dual proteasome and HDAC6 inhibition
Abstract Background: Anti-CD38 monoclonal antibodies (mAbs) constitute a revolutionary class of targeted immunotherapeutic agents that have...
Integrated machine learning-based prognostic models for patients with Myelodysplastic Syndromes/neoplasms (MDS)
Abstract Introduction Prognostic models like the IPSS-R and IPSS-M focus on the biology of the disease but ignore patient-related factors su...
The effect of underlying hereditary hemolytic disorders on hospital resource utilization in babesiosis-associated hospitalizations: A national inpatient sample analysis 2016–2022
Abstract Title: The Effect of Underlying Hereditary Hemolytic Disorders on Hospital Resource Utilization in Babesiosis-Associated Hospitaliz...
Impact of baseline suvmax in untreated high-tumor-burden follicular lymphoma
Abstract Background: Positron emission tomography is considered the reference imaging technique for the initial staging and therapeutic asses...
Impact of age on outcomes of CAR-T cell therapy in multiple myeloma, DLBCL, and follicular lymphoma: A real-world multi-center propensity-matched analysis
Abstract Background Chimeric antigen receptor T-cell (CAR-T) therapy has transformed the management of relapsed and refractory hematologic m...
Pretargeted glycoengineered NK cell (PG-NK) therapy: A universal off-the-shelf platform redefining targeted cell therapy strategies in lymphoma
Abstract Chimeric Antigen Receptor T cell (CAR-T) therapy has transformed cancer treatment. However, its application is hindered by complex...
Is functional cure possible in follicular lymphoma? analysis and development of a predictive model for long-term progression-free (PFS15) patients
Abstract Introduction: Follicular lymphoma (FL) is an indolent lymphoma characterized by a chronic course with remissions and relapses. Whil...
Impact of preexisting mental health disorders and psychiatric pharmacotherapy on hospital length of stay in immune effector cell therapy recipients
Abstract Introduction Chimeric antigen receptor T-cell therapy (CAR-T) and bispecific T-cell engagers (BiTE) have revolutionized cancer trea...
Vorinostat for GVHD prophylaxis in children, adolescents, and young adults (AYA) shows low incidence of acute GVHD and relapse with encouraging overall survival after allogeneic hematopoietic cell transplantation (HCT): A multisite, nonrandomized clinical trial
Abstract Background: Graft-versus-host disease (GVHD) remains a significant complication following allogeneic HCT. At lower doses, histone d...
ROCK2 inhibition attenuates CTL-mediated platelet destruction by suppressing IL-6/STAT3-driven glycolysis in primary immune thrombocytopenia
Abstract Abstract Primary immune thrombocytopenia (ITP) is an autoimmune disorder characterized by excessive platelet destruction, in which...