Blood
Articles in this Issue
Prognostic value of interim PET in patients with extranodal natural killer/T-cell lymphoma treated with non-anthracycline containing l-asparaginase based regimen
Abstract Background Extranodal natural killer/T-cell lymphoma (ENKTL) is a rare subtype of non-Hodgkin lymphoma predominantly involving the...
Maternal morbidity and predictors of adverse outcomes in pregnant women with sickle cell disease: A nationwide analysis (2022)
Abstract Background: Pregnancy in women with sickle cell disease (SCD) is associated with high maternal morbidity, yet n...
Real-world chronic lymphocytic leukemia (CLL)–specific biomarker testing patterns and frontline treatment patterns in patients with CLL/small lymphocytic lymphoma (SLL)
Abstract Introduction: CLL/SLL is the most common leukemia in adults in the United States, with ~21,000 cases diagnosed annually. National C...
Integrating next-generation sequencing disease evaluation and PCR based CAR-T cell tracking to guide decision making in a real-world cohort of pediatric B-cell ALL patients.
Abstract Background: Chimeric antigen receptor T-cell (CAR-T) therapy is an effective treatment option for relapsed/refractory pediatric B-c...
Comparative outcomes of fludarabine-melphalan versus fludarabine-busulfan reduced-intensity conditioning for allogeneic hematopoietic stem cell transplantation in patients with hematologic malignancies: A systematic review and meta-analysis
Abstract Background: Reduced-intensity conditioning (RIC) regimens with fludarabine plus melphalan (FluMel) or busulfan (FluBu) are common i...
Superficial vein thrombosis of the upper extremities: A retrospective analysis of clot progression and role of thrombophilia testing
Abstract Introduction: There are well-established guidelines for the treatment of lower extremity (LE) deep venous thrombosis (DVT), but gui...
Characteristics, epidemiology and outcomes of post-transplant lymphoproliferative disorders associated hospitalizations: A 2016-2022 national inpatient sample analysis
Abstract Introduction: Post-transplant lymphoproliferative disorders (PTLD) are rare but serious lymphoid proliferations following solid org...
Menin inhibition as a new therapeutic option for the myeloproliferative neoplasms
Abstract Menin inhibition has emerged as an exciting therapeutic strategy for acute myeloid leukemia associated with KMT2A-rearrangements an...
Manufacturing variability of CAR-T cells in patients with B-cell lymphoma: Findings from the carthiae-1 clinical trial
Abstract Background: Chimeric Antigen Receptor T-cell (CAR-T) therapy has emerged as a promising treatment modality for patients with relaps...
Asciminib for relapsed or refractory Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL) and lymphoid blast crisis of chronic myeloid leukemia (LBC-CML) in Italy: A Campus ALL real life study
Abstract Background: The introduction of tyrosine kinase inhibitors (TKIs) has markedly improved the outcome of Philadelphia positive acute...
Tfeb regulates CD8+ T-cell proliferation In Vivo
Abstract CD8+ T-cells are critical components of anti-viral and anti-tumor immunity. Our accumulating understanding of their function has al...
Trends in mortality due to hematological malignancies and aplastic anemia in US adults from 1999-2023: A 24-year retrospective analysis of the CDC wonder database
Abstract Introduction: Hematologic malignancies have caused over 1.4 million deaths among U.S. adults between 1999 and 2020, with 185,840 ne...
Social determinants of health and outcomes in patients with acute leukemia: Interim results from a prospective, single institution study
Abstract Introduction: Individual and population-based social determinants of health (SDOH) have been shown to negativel...
Efficacy of a virtual reality headset for managing severe pain during sickle cell vaso-occlusive crisis: A single-center study in adults.
Abstract Background: In adult patients with sickle cell disease (SCD), regular use of opioid analgesics during a vaso-occlusive crisis (VOC)...
Effectiveness and safety of polatuzumab vedotin combined with zuberitamab plus cyclophosphamide, doxorubicin and prednisone in untreated diffuse large B-cell lymphoma: A real-world study from China
Abstract Introduction Polatuzumab vedotin (pola) plus rituximab, cyclophosphamide, doxorubicin, and prednisone (R-CHP) d...
Engineered extracellular vesicles for In Vivo gene therapy in sickle cell disease
Abstract Sickle Cell Disease (SCD) is a genetic blood disorder that affects over 100,000 persons in the U.S. and 20 million people worldwide...
Shifting treatment paradigms lead to improved overall survival in Acute Myeloid Leukemia: Real-world data from an integrated health system.
Abstract Introduction: For the past decade, treatment options for acute myeloid leukemia (AML) have evolved with the approval of hypomethyla...
Multi-faceted influence of immunomodulatory metabolites on CAR-T cell therapy
Abstract Background:Chimeric antigen receptor (CAR) T cell therapy has revolutionized treatment for hematologic malignancies achieving high...
Increasing the proportion, accessibility, and quality of individualized pain plans for adults with sickle cell disease
Abstract Introduction: Sickle cell disease (SCD) is characterized by recurrent episodes of severe pain, often necessitating treatment in acu...
Pilot study on thrombosis risk factors in sickle cell anemia
Abstract Background:Sickle cell disease (SCD) is a complex hemoglobinopathy affecting approximately 70,000–100,000 individuals in the United...
Quality of life and symptom burden in PNH: A real-world study on the impact of treatment access
Abstract Introduction Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, life-threatening hematologic disorder characterized by complement...
The CML and the ALL inducing isoforms of BCR::ABL1 differ for the induction of genomic instablity
Abstract There are two major isoforms of BCR::ABL1, the Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) specific p18...
Correction of ineffective erythropoiesis and durable clinical benefit with exagamglogene autotemcel for transfusion-dependent β-thalassemia
Abstract Background: Transfusion-dependent β-thalassemia (TDT) patients have tissue iron overload (IO) from chronic red blood cell (RBC) tra...
17p loss in TP53-non-mutated myeloid neoplasms confers survival comparable to TP53-mutated disease
Abstract Introduction: The 5th edition of the World Health Organization (WHO-5) and the International Consensus Classification (ICC) recogniz...
Spatial transcriptomics uncovers unique tumor microenvironments in folliculotropic versus classic mycosis fungoides
Abstract Introduction: The most common subtype of cutaneous T-cell lymphoma (CTCL), mycosis fungoides (MF), is characterized by proliferatio...