Blood
Articles in this Issue
Pregnancy-associated atypical hemolytic uremic syndrome: A systematic review and meta-analysis of clinical features, treatment strategies, and Maternal–Fetal outcomes
Abstract Background: Atypical hemolytic uremic syndrome (aHUS) in pregnancy is a rare and life-threatening thrombotic microangiopathy (TMA)....
Single-cell analysis reveals distinct γ-globin expression profiles in sickle cell disease with pancellular fetal hemoglobin
Abstract Around birth, red blood cell (RBC) β-like globin expression transitions from γ-globin (HBG1/HBG2; HBG) to β-globin (HBB), resulting...
A cyno cross reactive CD3 VHH antibody enables engineering of a potent CD20-targeted t cell engager with enhanced safety
Abstract Introduction: Due to the clinical successes of multiple B cell-depleting chimeric antigen receptor (CAR)-T cell and T cell engager (...
Sonic: Escalated inpatient ramp-up of sonrotoclax in CLL/SLL and MCL
Abstract Background: Bcl-2 inhibitors have well-established efficacy in the treatment of chronic lymphocytic leukemia (CLL)/ small lymphocyt...
Efficacy of the JAK2/FLT3 inhibitor pacritinib in NPM1 mutated Acute Myeloid Leukemia
Abstract Background Acute myeloid leukemia (AML) with mutation in NPM1 (NPM1mut) represents a third ofadult AML cases (Falini et al., 2020)....
Chimeric antigen receptor T-cell therapy in patients with coexisting malignancy and autoimmune disease
Abstract Background: Chimeric antigen receptor (CART) therapies targeting CD19 or BCMA have shown great potential for treating autoimmune di...
Primary analysis of a multicenter, open-label, phase 2 study of sonrotoclax (BGB-11417) monotherapy in patients with relapsed/refractory (R/R) chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL/SLL)
Abstract Introduction: B-cell lymphoma 2 (BCL2) inhibition is an established treatment strategy in CLL/SLL with the potential to induce deep...
Targeting CCR7 ubiquitination to disrupt protumoral macrophages: A NEDD4-1-dependent strategy to reverse bortezomib resistance in myeloma
Abstract Background: Chemotherapy resistance in multiple myeloma (MM) is associated with MM-associated macrophages (mMΦs). Although the E3 u...
Multi-proteomic analyses provide evidence for origin of a co-existing serum monoclonal gammopathy in CLL/MBL
Abstract INTRODUCTION Chronic Lymphocytic Leukemia (CLL) is the most frequent leukemia in adults and is typically preceded by a pre-malignan...
Leonurine significantly enhance the activity of dendritic cells derived from chronic myeloid Leukemia Patients
Abstract Aim: To explore the modulatory effect of leonurine on monocyte-derived DCs (moDCs) from chronic myeloid leukemi...
Unwelcome guests: Risk factors for multidrug-resistant bacterial infections in adults with acute lymphoblastic leukemia
Abstract Introduction: Despite significant improvements in survival among adult patients with acute lymphoblastic leukem...
Outcomes of primary cutaneous anaplastic large cell lymphoma across u.S. cancer care settings: A national cancer database analysis.
Abstract Background: Primary cutaneous (PC) anaplastic large cell lymphoma (-ALCL) represents 8% of cutaneous lymphoma c...
Apolipoproteins from the microenvironment promote aggressive myeloid leukemia progression
Abstract The bone marrow microenvironment consists of diverse cell populations, including mesenchymal stromal cells (MSCs), osteolineage cel...
Olverembatinib (HQP1351) demonstrates efficacy vs. best available therapy (BAT) in patients (pts) with tyrosine kinase inhibitor (TKI)-resistant chronic-Phase chronic myeloid leukemia (CML-CP) in a registrational randomized Phase 2 trial: Up to 4-year follow-up including patients without T315I mutations
Abstract Introduction This was a multicenter, randomized, registrational phase 2 study to assess efficacy and safety of olverembatinib vs. BA...
Favorable preliminary safety and efficacy of mosunetuzumab plus ICE or DHAX salvage chemotherapy in relapsed/refractory large B-cell lymphoma
Abstract Background: Patients (pts) with R/R LBCL often have a poor prognosis. For pts relapsing >1 year after frontline therapy, sta...
Global, regional, and national trends in the burden of chronic myeloid leukemia from 1990 to 2021: A comprehensive analysis of the 2021 global burden of disease study and projections to 2050
Abstract Background: Chronic myeloid leukemia (CML) has emerged as a critical public health concern, yet current research on its disease bur...
Phase 2 study of aponermin +kt-decp in patients(pts) with Relapsed/Refractory multiple myeloma and extramedullary disease
Abstract Background and Aims： The survival of Relapsed/refractory multiple myeloma (RRMM) with extramedullary Disease (EMD) was still poor...
Lymphodepletion-free jl-lightning CAR-T targeting CD19/CD22/BCMA achieved 100% CR in 3 Relapsed/Refractory B-NHL patients: A lymphodepletion regimen comparison study
Abstract Background: Broad clinical application of CAR-T therapy has been constrained by several barriers: (1) prolonged manufacturing proce...
Integrating bispecific antibodies into community myeloma care: Challenges, insights, and educational impact
Abstract BACKGROUND: The integration of bispecific antibodies into community oncology practice offers promising therapeutic advancements but...
Combination of CPX-351 and gemtuzumab ozogamicin (GO) in relapsed/refractory (R/R) Acute Myeloid Leukemia and post-hypomethylating agent (HMA) failure high-risk myelodysplastic syndrome (HR-MDS)
Abstract Background: The outcome of patients (pts) with R/R AML or MDS after failing HMA and/or BCL-2 inhibitor combinations is poor and lac...
Multicenter assessment of absolute neutrophil counts (ANC) and white blood cell counts (WBC) in healthy participants with the erythrocyte duffy null phenotype or genotype
Abstract Introduction: The Duffy null variant (genotype or phenotype) is associated with lower circulating absolute neutrophil counts (ANC)...
Optimizing emergency department care for people with bleeding disorders: A scoping review of barriers and interventions for improvement
Abstract BACKGROUND People with bleeding disorders often require emergency department (ED) care due to increased risk of life-threatening spo...
High prognostic value of NGS-based measurable residual FLT3-ITD in AML patients positive for FLT3-ITD treated with ponatinib in combination with cytarabine in first complete remission.
Abstract Introduction: FLT3 internal tandem duplications (ITD) are among the most frequent genetic alteration, found in approximately 30% AM...
Single-cell chromatin profiling reveals early epigenetic reprogramming, subtype-specific regulatory networks, and JAK/STAT–IRF vulnerabilities in high-risk chronic myeloid leukemia
Abstract Myeloproliferative neoplasms (MPNs), including chronic myeloid leukemia (CML), are oncogene-driven blood cancers arising from hemat...
Development and validation of a machine Learning–Based clinical prediction model for hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation in thalassemia major
Abstract Background: Hemorrhagic cystitis (HC) is a frequent and debilitating complication after allogeneic hematopoietic stem cell transpla...